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Rat liver lipogenesis is modulated by interleukin-15

  • Authors:
    • Joaquín López-Soriano
    • Neus Carbó
    • Vanessa Almendro
    • Maite Figueras
    • Vicent Ribas
    • Sílvia Busquets
    • Francisco J. López-Soriano
    • Josep M. Argilés

  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/ijmm.13.6.817
  • Pages: 817-819
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Interleukin-15 (IL-15) administration to rats resulted in an important decrease in carcass fat (27%) and, consequently, in white adipose tissue mass. This decrease was linked with a decreased lipogenic rate (per g of tissue) in both adipose tissue (53%) and liver (36%). The decrease in hepatic lipogenesis was associated with lower hepatic citrate levels (49%) and a reduced activity of lipogenic enzymes. The results presented here further demonstrate the involvement of IL-15 in lipid metabolism. Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase.

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Journal Cover

June 2004
Volume 13 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
López-Soriano J, Carbó N, Almendro V, Figueras M, Ribas V, Busquets S, López-Soriano FJ and Argilés JM: Rat liver lipogenesis is modulated by interleukin-15. Int J Mol Med 13: 817-819, 2004.
APA
López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S. ... Argilés, J.M. (2004). Rat liver lipogenesis is modulated by interleukin-15. International Journal of Molecular Medicine, 13, 817-819. https://doi.org/10.3892/ijmm.13.6.817
MLA
López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S., López-Soriano, F. J., Argilés, J. M."Rat liver lipogenesis is modulated by interleukin-15". International Journal of Molecular Medicine 13.6 (2004): 817-819.
Chicago
López-Soriano, J., Carbó, N., Almendro, V., Figueras, M., Ribas, V., Busquets, S., López-Soriano, F. J., Argilés, J. M."Rat liver lipogenesis is modulated by interleukin-15". International Journal of Molecular Medicine 13, no. 6 (2004): 817-819. https://doi.org/10.3892/ijmm.13.6.817