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Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage

  • Authors:
    • Yuanyuan Wu
    • Jun Cui
    • Xiaofeng Bao
    • Siopeng Chan
    • D. Owen Young
    • Dan Liu
    • Pingping Shen

  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijmm.17.1.141
  • Pages: 141-150
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Triptolide is a natural, biologically active compound extracted from the Chinese herb Tripterygium Wilfordii hook, that possesses potent immunosuppressive properties. In the course of our study, we examined the effects of triptolide on stimulated murine macrophages and demonstrated that triptolide inhibited superoxide anion production, NO production, and the expression of iNOS mRNA and the mRNA of some key inflammation-related cytokines, namely TNF-α, IL-1β, IL-6 and IFN-γ. This inhibition was accompanied by the inhibition of nuclear transcription factor NF-κB activation. We further developed a mathematical model to simulate interplay between triptolide, ROS, NF-κB, iNOS and related cytokines. Our results suggest that triptolide acts to regulate inflammation through NF-κB-mediated inhibition of inflammation-related cytokines and the production of superoxide anion and NO.

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Journal Cover

January 2006
Volume 17 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Wu Y, Cui J, Bao X, Chan S, Young DO, Liu D and Shen P: Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int J Mol Med 17: 141-150, 2006.
APA
Wu, Y., Cui, J., Bao, X., Chan, S., Young, D.O., Liu, D., & Shen, P. (2006). Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage. International Journal of Molecular Medicine, 17, 141-150. https://doi.org/10.3892/ijmm.17.1.141
MLA
Wu, Y., Cui, J., Bao, X., Chan, S., Young, D. O., Liu, D., Shen, P."Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage". International Journal of Molecular Medicine 17.1 (2006): 141-150.
Chicago
Wu, Y., Cui, J., Bao, X., Chan, S., Young, D. O., Liu, D., Shen, P."Triptolide attenuates oxidative stress, NF-κB activation and multiple cytokine gene expression in murine peritoneal macrophage". International Journal of Molecular Medicine 17, no. 1 (2006): 141-150. https://doi.org/10.3892/ijmm.17.1.141