search button

Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP

  • Authors:
    • Maoqing Wu
    • Gang Yin
    • Xin Zhao
    • Chaoneng Ji
    • Shaohua Gu
    • Rong Tang
    • Hai Dong
    • Yi Xie
    • Yumin Mao

  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/ijmm.17.5.749
  • Pages: 749-754
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

As an atypical member of the Rab family, Rab24 has several attributes distinguishing this protein from the other members. Based on the yeast two-hybrid system, interaction between human RAB24 and two proteins, cyclophilin A (CyP-A) and gamma-aminobutyric acid type A receptor-associated protein (GABARAP), was detected and identified in COS-7 cells. Interestingly, RAB24 is predominantly localized in the nuclei of COS-7 cells, which is different from previous reports using other cell lines. RAB24 (D123I) can trigger the accumulation of intracellular inclusions, with small quantities of intranuclear inclusions in some cells. The GTPase activity of RAB24 and its two mutants was detected.

Related Articles

Journal Cover

May 2006
Volume 17 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Yin G, Zhao X, Ji C, Gu S, Tang R, Dong H, Xie Y and Mao Y: Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP. Int J Mol Med 17: 749-754, 2006.
APA
Wu, M., Yin, G., Zhao, X., Ji, C., Gu, S., Tang, R. ... Mao, Y. (2006). Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP. International Journal of Molecular Medicine, 17, 749-754. https://doi.org/10.3892/ijmm.17.5.749
MLA
Wu, M., Yin, G., Zhao, X., Ji, C., Gu, S., Tang, R., Dong, H., Xie, Y., Mao, Y."Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP". International Journal of Molecular Medicine 17.5 (2006): 749-754.
Chicago
Wu, M., Yin, G., Zhao, X., Ji, C., Gu, S., Tang, R., Dong, H., Xie, Y., Mao, Y."Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP". International Journal of Molecular Medicine 17, no. 5 (2006): 749-754. https://doi.org/10.3892/ijmm.17.5.749