search button

8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.

  • Authors:
    • K Igarashi
    • T Isohara
    • T Kato
    • K Takigawa
    • K Shigeta
    • T Yamano
    • I Uno

  • View Affiliations

  • Published online on: August 1, 1998     https://doi.org/10.3892/ijmm.2.2.211
  • Pages: 211-426
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR/Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibited the MAPK phosphorylation in HUVEC induced by VEGF or basic FGF but not by EGF. 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid might be used as an inhibitor of VEGF and basic FGF signal transduction.

Related Articles

Journal Cover

Aug 1998
Volume 2 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Igarashi K, Isohara T, Kato T, Takigawa K, Shigeta K, Yamano T and Uno I: 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.. Int J Mol Med 2: 211-426, 1998.
APA
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., & Uno, I. (1998). 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.. International Journal of Molecular Medicine, 2, 211-426. https://doi.org/10.3892/ijmm.2.2.211
MLA
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., Uno, I."8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.". International Journal of Molecular Medicine 2.2 (1998): 211-426.
Chicago
Igarashi, K., Isohara, T., Kato, T., Takigawa, K., Shigeta, K., Yamano, T., Uno, I."8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)-1-naphthoic acid inhibits MAPK phosphorylation in endothelial cells induced by VEGF and bFGF.". International Journal of Molecular Medicine 2, no. 2 (1998): 211-426. https://doi.org/10.3892/ijmm.2.2.211