Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries

  • Authors:
    • Mitsutoshi Oguri
    • Kimihiko Kato
    • Takeshi Hibino
    • Kiyoshi Yokoi
    • Tomonori Segawa
    • Hitoshi Matsuo
    • Sachiro Watanabe
    • Yoshinori Nozawa
    • Toyoaki Murohara
    • Yoshiji Yamada
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/ijmm.20.4.533
  • Pages: 533-538
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Abstract

The purpose of the present study was to identify gene polymorphisms that confer susceptibility to recurrent restenosis after bare-metal stenting of coronary arteries, and thereby to assess the genetic risk for this condition. The study population comprised 527 unrelated Japanese individuals, including 28 subjects who developed in-stent restenosis two or more times and 499 subjects without restenosis. The genotypes for 142 polymorphisms of 121 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Eleven polymorphisms were related (P<0.05) to the prevalence of recurrent in-stent restenosis as determined by the Chi-square test. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hypercholesterolemia revealed that the -55C↷T polymorphism of the uncoupling protein 3 gene (UCP3) was significantly (P=0.0006 in a recessive model) associated with the prevalence of recurrent in-stent restenosis, with the T allele representing a risk factor for this condition. A stepwise forward selection procedure showed that the UCP3 genotype significantly (P=0.0014, recessive model) affected the prevalence of recurrent in-stent restenosis. Determination of the genotype for UCP3 may thus contribute to assessment of the genetic risk for recurrent in-stent restenosis.

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October 2007
Volume 20 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Oguri M, Kato K, Hibino T, Yokoi K, Segawa T, Matsuo H, Watanabe S, Nozawa Y, Murohara T, Yamada Y, Yamada Y, et al: Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. Int J Mol Med 20: 533-538, 2007.
APA
Oguri, M., Kato, K., Hibino, T., Yokoi, K., Segawa, T., Matsuo, H. ... Yamada, Y. (2007). Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. International Journal of Molecular Medicine, 20, 533-538. https://doi.org/10.3892/ijmm.20.4.533
MLA
Oguri, M., Kato, K., Hibino, T., Yokoi, K., Segawa, T., Matsuo, H., Watanabe, S., Nozawa, Y., Murohara, T., Yamada, Y."Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries". International Journal of Molecular Medicine 20.4 (2007): 533-538.
Chicago
Oguri, M., Kato, K., Hibino, T., Yokoi, K., Segawa, T., Matsuo, H., Watanabe, S., Nozawa, Y., Murohara, T., Yamada, Y."Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries". International Journal of Molecular Medicine 20, no. 4 (2007): 533-538. https://doi.org/10.3892/ijmm.20.4.533