Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus

  • Authors:
    • Yoshiji Yamada
    • Hitoshi Matsuo
    • Sachiro Watanabe
    • Kimihiko Kato
    • Kazuhiro Yajima
    • Takeshi Hibino
    • Kiyoshi Yokoi
    • Sahoko Ichihara
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yoshinori Nozawa
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/ijmm.20.5.703
  • Pages: 703-707
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Abstract

Although several environmental factors, including a high-calorie diet and physical inactivity, influence the development of type 2 diabetes mellitus, genetic factors have been shown to contribute to individual susceptibility to this condition. The purpose of the present study was to identify gene polymorphisms that confer susceptibility or resistance to type 2 diabetes mellitus, and thereby to contribute to assessment of the genetic risk for this condition. The study population comprised 5259 unrelated Japanese individuals (2980 men, 2279 women), including 1640 subjects with type 2 diabetes mellitus (1071 men, 569 women) and 3619 controls (1909 men, 1710 women). The genotypes for 94 polymorphisms of 67 genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Evaluation of genotype distributions by the chi-square test revealed that the 13989A↷G (Ile118Val) polymorphism of the cytochrome P450, subfamily IIIA, polypeptide 4 gene (CYP3A4) was significantly (false discovery rate, 0.000009) associated with the prevalence of type 2 diabetes mellitus. Multivariable logistic regression analysis with adjustment for age and sex also revealed that the 13989A↷G (Ile118Val) polymorphism of CYP3A4 was significantly (P=0.00002) associated with the prevalence of type 2 diabetes mellitus, with the AG genotype being protective against this condition. Genotyping for CYP3A4 may thus prove informative for assessment of the genetic risk for type 2 diabetes mellitus.

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november 2007
Volume 20 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yamada Y, Matsuo H, Watanabe S, Kato K, Yajima K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Yoshida H, et al: Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus. Int J Mol Med 20: 703-707, 2007.
APA
Yamada, Y., Matsuo, H., Watanabe, S., Kato, K., Yajima, K., Hibino, T. ... Nozawa, Y. (2007). Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus. International Journal of Molecular Medicine, 20, 703-707. https://doi.org/10.3892/ijmm.20.5.703
MLA
Yamada, Y., Matsuo, H., Watanabe, S., Kato, K., Yajima, K., Hibino, T., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., Nozawa, Y."Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus". International Journal of Molecular Medicine 20.5 (2007): 703-707.
Chicago
Yamada, Y., Matsuo, H., Watanabe, S., Kato, K., Yajima, K., Hibino, T., Yokoi, K., Ichihara, S., Metoki, N., Yoshida, H., Satoh, K., Nozawa, Y."Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus". International Journal of Molecular Medicine 20, no. 5 (2007): 703-707. https://doi.org/10.3892/ijmm.20.5.703