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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2011 Volume 28 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2011 Volume 28 Issue 3

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Article

Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells

  • Authors:
    • Debora A. Casolari
    • Michelly C. Pereira
    • Simone A. de Bessa Garcia
    • Maria A. Nagai

  • View Affiliations / Copyright

    Affiliations: Disciplina de Oncologia, Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, 01246-903 Sao Paulo, Brazil, Disciplina de Oncologia, Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, Av. Dr Arnaldo, 455, 4˚ andar, 01246-903 Sao Paulo, Brazil
  • Pages: 337-342
    |
    Published online on: May 6, 2011
       https://doi.org/10.3892/ijmm.2011.691
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Abstract

The PKC apoptosis WT1 regulator gene, also named prostate apoptosis response-4 (PAR-4), encodes a pro-apoptotic protein that sensitizes cells to numerous apoptotic stimuli. Insulin-like growth factor-1 (IGF-1) and 17β-estradiol (E2), two important factors for breast cancer development and progression, have been shown to down-regulate PAR-4 expression and inhibit apoptosis induced by PAR-4 in neuronal cells. In this study, we sought to investigate the mechanisms of regulation of PAR-4 gene expression in MCF-7 cells treated with E2 or IGF-1. E2 (10 nM) and IGF-1 (12.5 nM) each down-regulated PAR-4 expression in MCF-7 cells after 24 h of treatment. The effect of E2 was dependent on ER activation, as demonstrated by an increase in PAR-4 expression when cells were pretreated for 1 h with 1 µM ICI-182,780 (ICI) before receiving E2 plus ICI. The effect of IGF-1 was abolished by pre-treatment for 1 h with 30 µM LY294002 (a specific PI3-K inhibitor), and significantly inhibited by 30 µM SB202190 (a specific p38MAPK inhibitor). We also demonstrated that E2 acts synergistically with IGF-1, resulting in greater down-regulation of PAR-4 mRNA expression compared with E2 or IGF-1 alone. Our results show for the first time that E2 and IGF-1 inhibit PAR-4 gene expression in MCF-7 cells, suggesting that this down-regulation may provide a selective advantage for breast cancer cell survival.

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Copy and paste a formatted citation
Spandidos Publications style
Casolari DA, Pereira MC, de Bessa Garcia SA and Nagai MA: Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells. Int J Mol Med 28: 337-342, 2011.
APA
Casolari, D.A., Pereira, M.C., de Bessa Garcia, S.A., & Nagai, M.A. (2011). Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells. International Journal of Molecular Medicine, 28, 337-342. https://doi.org/10.3892/ijmm.2011.691
MLA
Casolari, D. A., Pereira, M. C., de Bessa Garcia, S. A., Nagai, M. A."Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells". International Journal of Molecular Medicine 28.3 (2011): 337-342.
Chicago
Casolari, D. A., Pereira, M. C., de Bessa Garcia, S. A., Nagai, M. A."Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells". International Journal of Molecular Medicine 28, no. 3 (2011): 337-342. https://doi.org/10.3892/ijmm.2011.691
Copy and paste a formatted citation
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Spandidos Publications style
Casolari DA, Pereira MC, de Bessa Garcia SA and Nagai MA: Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells. Int J Mol Med 28: 337-342, 2011.
APA
Casolari, D.A., Pereira, M.C., de Bessa Garcia, S.A., & Nagai, M.A. (2011). Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells. International Journal of Molecular Medicine, 28, 337-342. https://doi.org/10.3892/ijmm.2011.691
MLA
Casolari, D. A., Pereira, M. C., de Bessa Garcia, S. A., Nagai, M. A."Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells". International Journal of Molecular Medicine 28.3 (2011): 337-342.
Chicago
Casolari, D. A., Pereira, M. C., de Bessa Garcia, S. A., Nagai, M. A."Insulin-like growth factor-1 and 17β-estradiol down-regulate prostate apoptosis response-4 expression in MCF-7 breast cancer cells". International Journal of Molecular Medicine 28, no. 3 (2011): 337-342. https://doi.org/10.3892/ijmm.2011.691
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