State-of-the-art bioinformatics protein structure prediction tools (Review)
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- Published online on: May 23, 2011 https://doi.org/10.3892/ijmm.2011.705
- Pages: 295-310
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Abstract
Knowledge of the native structure of a protein could provide an understanding of the molecular basis of its function. However, in the postgenomics era, there is a growing gap between proteins with experimentally determined structures and proteins without known structures. To deal with the overwhelming data, a collection of automated methods as bioinformatics tools which determine the structure of a protein from its amino acid sequence have emerged. The aim of this paper is to provide the experimental biologists with a set of cutting-edge, carefully evaluated, user-friendly computational tools for protein structure prediction that would be helpful for the interpretation of their results and the rational design of new experiments.
