miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells

Zhao,Haien; Guo,Mingjun; Zhao,Guangyi; Ma,Qiong; Ma,Baoan; Qiu,Xiuchun; Fan,Qingyu

doi:10.3892/ijmm.2012.1111

miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells

Authors:
- Haien Zhao
- Mingjun Guo
- Guangyi Zhao
- Qiong Ma
- Baoan Ma
- Xiuchun Qiu
- Qingyu Fan
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Affiliations: Department of Orthopaedic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
Published online on: August 24, 2012 https://doi.org/10.3892/ijmm.2012.1111
Pages: 1013-1020
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Osteosarcoma is the most common primary malignancy of bone in teenagers and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. Recent studies suggest that the Ezrin protein is correlated with the metastatic potential of several malignant tumors. In our study, ectopic overexpression of miR-183 repressed the expression levels of Ezrin and significantly inhibited the motility and invasion of osteosarcoma cells. This suggests that miR-183 may possibly play a tumor suppressor role in the metastasis of osteosarcoma by downregulating Ezrin expression levels. These findings show that through inhibition of Ezrin expression levels, miR-183 is significantly involved in cell migration and invasion of osteosarcoma.

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