GPR40: A therapeutic target for mediating insulin secretion (Review)

  • Authors:
    • Xiao-Tao Feng
    • Jing Leng
    • Zhen Xie
    • Shuang-Lei Li
    • Wei Zhao
    • Qian-Li Tang
  • View Affiliations

  • Published online on: September 26, 2012     https://doi.org/10.3892/ijmm.2012.1142
  • Pages: 1261-1266
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Abstract

G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.
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December 2012
Volume 30 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Feng X, Leng J, Xie Z, Li S, Zhao W and Tang Q: GPR40: A therapeutic target for mediating insulin secretion (Review). Int J Mol Med 30: 1261-1266, 2012.
APA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., & Tang, Q. (2012). GPR40: A therapeutic target for mediating insulin secretion (Review). International Journal of Molecular Medicine, 30, 1261-1266. https://doi.org/10.3892/ijmm.2012.1142
MLA
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30.6 (2012): 1261-1266.
Chicago
Feng, X., Leng, J., Xie, Z., Li, S., Zhao, W., Tang, Q."GPR40: A therapeutic target for mediating insulin secretion (Review)". International Journal of Molecular Medicine 30, no. 6 (2012): 1261-1266. https://doi.org/10.3892/ijmm.2012.1142