Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis

  • Authors:
    • Enrica Bianchi
    • Fabio Scarinci
    • Guido Ripandelli
    • Janos Feher
    • Elena Pacella
    • Giuseppe Magliulo
    • Corrado Balacco Gabrieli
    • Rocco Plateroti
    • Pasquale Plateroti
    • Fiorenzo Mignini
    • Marco Artico
  • View Affiliations

  • Published online on: October 26, 2012     https://doi.org/10.3892/ijmm.2012.1164
  • Pages: 232-242
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in AMD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical application in inflammatory and neovascular diseases of the eye.
View Figures
View References

Related Articles

Journal Cover

January 2013
Volume 31 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bianchi E, Scarinci F, Ripandelli G, Feher J, Pacella E, Magliulo G, Gabrieli CB, Plateroti R, Plateroti P, Mignini F, Mignini F, et al: Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis. Int J Mol Med 31: 232-242, 2013.
APA
Bianchi, E., Scarinci, F., Ripandelli, G., Feher, J., Pacella, E., Magliulo, G. ... Artico, M. (2013). Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis. International Journal of Molecular Medicine, 31, 232-242. https://doi.org/10.3892/ijmm.2012.1164
MLA
Bianchi, E., Scarinci, F., Ripandelli, G., Feher, J., Pacella, E., Magliulo, G., Gabrieli, C. B., Plateroti, R., Plateroti, P., Mignini, F., Artico, M."Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis". International Journal of Molecular Medicine 31.1 (2013): 232-242.
Chicago
Bianchi, E., Scarinci, F., Ripandelli, G., Feher, J., Pacella, E., Magliulo, G., Gabrieli, C. B., Plateroti, R., Plateroti, P., Mignini, F., Artico, M."Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis". International Journal of Molecular Medicine 31, no. 1 (2013): 232-242. https://doi.org/10.3892/ijmm.2012.1164