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Article

Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury

  • Authors:
    • Jiangcong Hong
    • Guangwen Wu
    • Yulong Zou
    • Jing Tao
    • Lidian Chen
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Subsidiary Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou 350003, P.R. China, Subsidiary of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350003, P.R. China, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, P.R. China
  • Pages: 225-231
    |
    Published online on: October 26, 2012
       https://doi.org/10.3892/ijmm.2012.1166
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Abstract

Neurogenesis is regulated by a number of signaling pathways, including the retinoic acid (RA) pathway, a key regulator of neurogenesis in the subventricular zone (SVZ) and hippocampus. Acupuncture has been used to treat neurological conditions and is known to potentially enhance cell proliferation in the neurogenic area (hippocampal dentate gyrus and the SVZ of the lateral ventricle walls) in pathological conditions, which is associated with improved brain function. However, whether or not the neuroprotective effects of electroacupuncture (EA) are mediated by the regulation of the RA signaling pathway remains to be determined. Using a transient middle cerebral artery occlusion model, in the present study we evaluated the effect of EA on the neurological functional recovery, infarction volume and investigated the underlying molecular mechanisms. Two hundred and sixteen SD rats were randomly divided into 3 groups: sham, model group (ischemic rats without EA stimulation) and EA group (ischemic rats with EA stimulation on ST36 and LI11). Behavioral deficits were detected with high-resolution digital analysis of 24-h home-cage video recordings. Infarct volume was determined by triphenyltetrazolium hydrochloride staining and the expression of RA mRNA and protein was measured using RT-PCR and western blotting, respectively. We found that EA decreased the infarct volume, promoted neurological functional recovery and increased the RA mRNA and protein expression, compared with the model group. Findings of this study suggest that promoting neurological functional recovery by modulating RA expression in the post-ischemic brain is one of the mechanisms by which EA can be effective in the treatment of ischemic stroke.
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1 

Lo EH, Dalkara T and Moskowitz MA: Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 4:399–415. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Madden K: Optimal timing of thrombolytic therapy in acute ischaemic stroke. CNS Drugs. 16:213–218. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Willaime-Morawek S and van der Kooy D: Cortex- and striatum-derived neural stem cells produce distinct progeny in the olfactory bulb and striatum. Eur J Neurosci. 27:2354–2362. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Nakagomi T, Taguchi A, Fujimori Y, Saino O, Nakano-Doi A, Kubo S, Gotoh A, Soma T, Yoshikawa H, Nishizaki T, Nakagomi N, Stern DM and Matsuyama T: Isolation and characterization of neural stem/progenitor cells from post-stroke cerebral cortex in mice. Eur J Neurosci. 29:1842–1852. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Jin K, Wang X, Xie L, Mao XO, Zhu W, Wang Y, Shen J, Mao Y, Banwait S and Greenberg DA: Evidence for stroke-induced neurogenesis in the human brain. Proc Natl Acad Sci USA. 103:13198–13202. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Macas J, Nern C, Plate KH and Momma S: Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. J Neurosci. 26:13114–13119. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Minger SL, Ekonomou A, Carta EM, Chinoy A, Perry RH and Ballard CG: Endogenous neurogenesis in the human brain following cerebral infarction. Regen Med. 2:69–74. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Landgren H and Curtis MA: Locating and labeling neural stem cells in the brain. J Cell Physiol. 226:1–7. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Hodge RD and Hevner RF: Expression and actions of transcription factors in adult hippocampal neurogenesis. Dev Neurobiol. 71:680–689. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ross SA, McCaffery PJ, Drager UC and De Luca LM: Retinoids in embryonal development. Physiol Rev. 80:1021–1054. 2000.PubMed/NCBI

11 

McCaffery P, Zhang J and Crandall JE: Retinoic acid signaling and function in the adult hippocampus. J Neurobiol. 66:780–791. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Werner EA and Deluca HF: Retinoic acid is detected at relatively high levels in the CNS of adult rats. Am J Physiol Endocrinol Metab. 282:E672–E678. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Calza L, Giuliani A, Fernandez M, Pirondi S, D’Intino G, Aloe L and Giardino L: Neural stem cells and cholinergic neurons: regulation by immunolesion and treatment with mitogens, retinoic acid, and nerve growth factor. Proc Natl Acad Sci USA. 100:7325–7330. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Haskell GT and LaMantia AS: Retinoic acid signaling identifies a distinct precursor population in the developing and adult forebrain. J Neurosci. 25:7636–7647. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Wang TW, Zhang H and Parent JM: Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway. Development. 132:2721–2732. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH and Evans RM: Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci USA. 103:3902–3907. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Mey J and McCaffery P: Retinoic acid signaling in the nervous system of adult vertebrates. Neuroscientist. 10:409–421. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Plane JM, Whitney JT, Schallert T and Parent JM: Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke. Exp Neurol. 214:125–134. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Ikeda R, Kurokawa MS, Chiba S, Yoshikawa H, Ide M, Tadokoro M, Nito S, Nakatsuji N, Kondoh Y, Nagata K, Hashimoto T and Suzuki N: Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury. Neurobiol Dis. 20:38–48. 2005. View Article : Google Scholar

20 

Kim EH, Jang MH, Shin MC, Lim BV, Kim HB, Kim YJ, Chung JH and Kim CJ: Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats. Neurosci Lett. 327:33–36. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Kim EH, Kim YJ, Lee HJ, Huh Y, Chung JH, Seo JC, Kang JE, Lee HJ, Yim SV and Kim CJ: Acupuncture increases cell proliferation in dentate gyrus after transient global ischemia in gerbils. Neurosci Lett. 297:21–24. 2001. View Article : Google Scholar

22 

Liu Q, Yu J, Mi WL, Mao-Ying QL, Yang R, Wang YQ and Wu GC: Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress. Life Sci. 81:1489–1495. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Cheng H, Yu J, Jiang Z, Zhang X, Liu C, Peng Y, Chen F, Qu Y, Jia Y, Tian Q, Xiao C, Chu Q, Nie K, Kan B, Hu X and Han J: Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice. Neurosci Lett. 432:111–116. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Naylor AS, Bull C, Nilsson MK, Zhu C, Bjork-Eriksson T, Eriksson PS, Blomgren K and Kuhn HG: Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. Proc Natl Acad Sci USA. 105:14632–14637. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Yun SJ, Park HJ, Yeom MJ, Hahm DH, Lee HJ and Lee EH: Effect of electroacupuncture on the stress-induced changes in brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett. 318:85–88. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Gao J, Wang S, Wang X and Zhu C: Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains. Neurol Sci. 32:369–374. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Jang MH, Shin MC, Lee TH, Lim BV, Shin MS, Min BI, Kim H, Cho S, Kim EH and Kim CJ: Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neurosci Lett. 347:5–8. 2003. View Article : Google Scholar : PubMed/NCBI

28 

The Ministry of Science and Technology of the People’s Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006 09 30

29 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

30 

Arvidsson A, Collin T, Kirik D, Kokaia Z and Lindvall O: Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med. 8:963–970. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Goings GE, Sahni V and Szele FG: Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury. Brain Res. 996:213–226. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Lichtenwalner RJ and Parent JM: Adult neurogenesis and the ischemic forebrain. J Cereb Blood Flow Metab. 26:1–20. 2006. View Article : Google Scholar

33 

Parent JM, Valentin VV and Lowenstein DH: Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J Neurosci. 22:3174–3188. 2002.PubMed/NCBI

34 

Parent JM, Vexler ZS, Gong C, Derugin N and Ferriero DM: Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol. 52:802–813. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS and Lowenstein DH: Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci. 17:3727–3738. 1997.PubMed/NCBI

36 

Zhang RL, Zhang ZG, Zhang L and Chopp M: Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience. 105:33–41. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Liden M and Eriksson U: Understanding retinol metabolism: structure and function of retinol dehydrogenases. J Biol Chem. 281:13001–13004. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Wang Y, Chiang YH, Su TP, Hayashi T, Morales M, Hoffer BJ and Lin SZ: Vitamin D(3) attenuates cortical infarction induced by middle cerebral arterial ligation in rats. Neuropharmacology. 39:873–880. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Doyle KP, Suchland KL, Ciesielski TM, Lessov NS, Grandy DK, Scanlan TS and Stenzel-Poore MP: Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke. 38:2569–2576. 2007. View Article : Google Scholar

40 

Sato Y, Meller R, Yang T, Taki W and Simon RP: Stereo-selective neuroprotection against stroke with vitamin A derivatives. Brain Res. 1241:188–192. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Harvey BK, Shen H, Chen GJ, Yoshida Y and Wang Y: Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats. Neurosci Lett. 369:138–141. 2004. View Article : Google Scholar : PubMed/NCBI

42 

McCaffery P and Drager UC: Regulation of retinoic acid signaling in the embryonic nervous system: a master differentiation factor. Cytokine Growth Factor Rev. 11:233–249. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Steele AD, Jackson WS, King OD and Lindquist S: The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington’s and prion diseases. Proc Natl Acad Sci USA. 104:1983–1988. 2007.PubMed/NCBI

44 

Otero L, Zurita M, Aguayo C, Bonilla C, Rodríguez A and Vaquero J: Video-Tracking-Box linked to Smart software as a tool for evaluation of locomotor activity and orientation in brain injured rats. J Neurosci Methods. 188:53–57. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Roedel A, Storch C, Holsboer F and Ohl F: Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice. Lab Anim. 40:371–381. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Spruijt BM and DeVisser L: Advanced behavioural screening: automated home cage ethology. Drug Discov Today Technol. 3:231–237. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Chen L, Zhang X, Chen-Roetling J and Regan RF: Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice. J Neurosurg. 114:1159–1167. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Stichel CC and Muller HW: Experimental strategies to promote axonal regeneration after traumatic central nervous system injury. Prog Neurobiol. 56:119–148. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Gao P, Shen F, Gabriel RA, Law D, Yang E, Yang GY, Young WL and SU H: Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 40:3596–3600. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Leasure JL and Grider M: The effect of mild post-stroke exercise on reactive neurogenesis and recovery of somatosensation in aged rats. Exp Neurol. 226:58–67. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hong J, Wu G, Zou Y, Tao J and Chen L: Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury. Int J Mol Med 31: 225-231, 2013.
APA
Hong, J., Wu, G., Zou, Y., Tao, J., & Chen, L. (2013). Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury. International Journal of Molecular Medicine, 31, 225-231. https://doi.org/10.3892/ijmm.2012.1166
MLA
Hong, J., Wu, G., Zou, Y., Tao, J., Chen, L."Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury". International Journal of Molecular Medicine 31.1 (2013): 225-231.
Chicago
Hong, J., Wu, G., Zou, Y., Tao, J., Chen, L."Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury". International Journal of Molecular Medicine 31, no. 1 (2013): 225-231. https://doi.org/10.3892/ijmm.2012.1166
Copy and paste a formatted citation
x
Spandidos Publications style
Hong J, Wu G, Zou Y, Tao J and Chen L: Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury. Int J Mol Med 31: 225-231, 2013.
APA
Hong, J., Wu, G., Zou, Y., Tao, J., & Chen, L. (2013). Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury. International Journal of Molecular Medicine, 31, 225-231. https://doi.org/10.3892/ijmm.2012.1166
MLA
Hong, J., Wu, G., Zou, Y., Tao, J., Chen, L."Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury". International Journal of Molecular Medicine 31.1 (2013): 225-231.
Chicago
Hong, J., Wu, G., Zou, Y., Tao, J., Chen, L."Electroacupuncture promotes neurological functional recovery via the retinoic acid signaling pathway in rats following cerebral ischemia-reperfusion injury". International Journal of Molecular Medicine 31, no. 1 (2013): 225-231. https://doi.org/10.3892/ijmm.2012.1166
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