Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB

  • Authors:
    • Bo-Mi Hwang
    • Eun-Mi Noh
    • Jong-Suk Kim
    • Jeong-Mi Kim
    • Jin-Ki Hwang
    • Hye-Kyung Kim
    • Jae-Seon Kang
    • Do-Sung Kim
    • Han-Jung Chae
    • Yong-Ouk You
    • Kang-Beom Kwon
    • Young-Rae Lee
  • View Affiliations

  • Published online on: December 4, 2012     https://doi.org/10.3892/ijmm.2012.1202
  • Pages: 477-483
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Abstract

Decursin, a coumarin compound, was originally isolated from the roots of Angelica gigas almost four decades ago, and it was found to exhibit cytotoxicity against various types of human cancer cells and anti-amnesic activity in vivo through the inhibition of AChE activity. However, the anti-skin photoaging effects of decursin have not been reported to date. In the present study, we investigated the inhibitory effects of decursin on the expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human dermal fibroblast (HDF) cells. Western blot analysis and real-time PCR revealed that decursin inhibited the ultraviolet (UV)B-induced expression of MMP-1 and MMP-3 in a dose-dependent manner. Decursin significantly blocked the UVB-induced activation of nuclear factor-κB (NF-κB). However, decursin showed no effect on MAPK or AP-1 activity. In this study, decursin prevented the UVB-induced expression of MMPs via the inhibition of NF-κB activation. In conclusion, decursin may be a potential agent for the prevention and treatment of skin photoaging.
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February 2013
Volume 31 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hwang B, Noh E, Kim J, Kim J, Hwang J, Kim H, Kang J, Kim D, Chae H, You Y, You Y, et al: Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB. Int J Mol Med 31: 477-483, 2013.
APA
Hwang, B., Noh, E., Kim, J., Kim, J., Hwang, J., Kim, H. ... Lee, Y. (2013). Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB. International Journal of Molecular Medicine, 31, 477-483. https://doi.org/10.3892/ijmm.2012.1202
MLA
Hwang, B., Noh, E., Kim, J., Kim, J., Hwang, J., Kim, H., Kang, J., Kim, D., Chae, H., You, Y., Kwon, K., Lee, Y."Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB". International Journal of Molecular Medicine 31.2 (2013): 477-483.
Chicago
Hwang, B., Noh, E., Kim, J., Kim, J., Hwang, J., Kim, H., Kang, J., Kim, D., Chae, H., You, Y., Kwon, K., Lee, Y."Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB". International Journal of Molecular Medicine 31, no. 2 (2013): 477-483. https://doi.org/10.3892/ijmm.2012.1202