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Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism

  • Authors:
    • Aftab Ali Shah
    • Petra Leidinger
    • Andreas Keller
    • Anke Wendschlag
    • Eckart Meese
    • Nikolaus Blin

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  • Published online on: January 10, 2012     https://doi.org/10.3892/ijmm.2012.881
  • Pages: 637-643
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The trefoil peptide family, consisting in mammals of three members namely TFF1, 2 and 3, plays a cytoprotective role in epithelial cells of various tissues, mainly in the digestive tract. Tff1, Tff2 or Tff3 knock-out mouse models developed various kinds of gastrointestinal impairment. microRNAs are known to be novel gene regulators. We aimed to investigate the physiological role of such miRNAs in Tff2 knock-out mice. Whole miRNome profiling and in silico analysis were performed for Tff2-KO and WT mice. Our latest data explored the role of miRNAs in the regulatory cascades and molecular processes of Tff2-/- mice. As much as 6% of the Tff2-KO mice miRNome was significantly dys-regulated. Further in silico analysis suggests that the respective dys-regulated part of the miRNome is involved in human pathological processes, including pancreatic, colorectal and basal cell cancer. Additionally, the dys-regulated miRNome targets pathways involved in carbohydrate metabolism and adipocytokine signaling. The latter links deficient caloric maintenance in Tff2 and previous observation in Tff3-KO mice with miRNAs. In summary, our proof-of-concept study indicates that miRNAs may play an important role in the regulatory processes of the trefoil peptide family, especially in the regulation of cancer-related cascades.
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Journal Cover

April 2012
Volume 29 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Shah AA, Leidinger P, Keller A, Wendschlag A, Meese E and Blin N: Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. Int J Mol Med 29: 637-643, 2012.
APA
Shah, A.A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., & Blin, N. (2012). Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism. International Journal of Molecular Medicine, 29, 637-643. https://doi.org/10.3892/ijmm.2012.881
MLA
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29.4 (2012): 637-643.
Chicago
Shah, A. A., Leidinger, P., Keller, A., Wendschlag, A., Meese, E., Blin, N."Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism". International Journal of Molecular Medicine 29, no. 4 (2012): 637-643. https://doi.org/10.3892/ijmm.2012.881