Piceatannol inhibits mast cell-mediated allergic inflammation

Ko,Yu-Jin; Kim,Hui-Hun; Kim,Eun-Jung; Katakura,Yoshinori; Lee,Won-Sup; Kim,Gon-Sup; Ryu,Chung-Ho

doi:10.3892/ijmm.2013.1283

Piceatannol inhibits mast cell-mediated allergic inflammation

Authors:
- Yu-Jin Ko
- Hui-Hun Kim
- Eun-Jung Kim
- Yoshinori Katakura
- Won-Sup Lee
- Gon-Sup Kim
- Chung-Ho Ryu
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Affiliations: Division of Applied Life Sciences (BK 21 Program), Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 660-701, Republic of Korea, Department of Genetic Resources Technology, Faculty of Agriculture, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan, Department of Internal Medicine, Institute of Health Sciences and Gyeongnam Regional Cancer Center, Gyeongsang National University School of Medicine, Jinju 660-702, Republic of Korea, School of Veterinary Medicine, Research Institute of Life Science, Gyeongsang National University School of Medicine, Jinju 660-701, Republic of Korea
Published online on: February 21, 2013 https://doi.org/10.3892/ijmm.2013.1283
Pages: 951-958

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Abstract

Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro‑inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro‑inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.

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