1.
|
Sherr CJ: The Pezcoller lecture: cancer
cell cycles revisited. Cancer Res. 60:3689–3695. 2000.PubMed/NCBI
|
2.
|
Sancho E, Batlle E and Clevers H:
Signaling pathways in intestinal development and cancer. Annu Rev
Cell Dev Biol. 20:695–723. 2004. View Article : Google Scholar
|
3.
|
Ruiz i Altaba A, Sanchez P and Dahmane N:
Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat
Rev Cancer. 2:361–372. 2002.PubMed/NCBI
|
4.
|
Singh G, Singh SK, Konig A, et al:
Sequential activation of NFAT and c-Myc transcription factors
mediates the TGF-beta switch from a suppressor to a promoter of
cancer cell proliferation. J Biol Chem. 285:27241–27250. 2010.
View Article : Google Scholar : PubMed/NCBI
|
5.
|
Ben-Porath I, Thomson MW, Carey VJ, et al:
An embryonic stem cell-like gene expression signature in poorly
differentiated aggressive human tumors. Nat Genet. 40:499–507.
2008. View
Article : Google Scholar : PubMed/NCBI
|
6.
|
Schmitz M, Temme A, Senner V, et al:
Identification of SOX2 as a novel glioma-associated antigen and
potential target for T cell-based immunotherapy. Br J Cancer.
96:1293–1301. 2007. View Article : Google Scholar : PubMed/NCBI
|
7.
|
Wegner M: From head to toes: the multiple
facets of Sox proteins. Nucleic Acids Res. 27:1409–1420. 1999.
View Article : Google Scholar : PubMed/NCBI
|
8.
|
Kamachi Y, Uchikawa M and Kondoh H:
Pairing SOX off: with partners in the regulation of embryonic
development. Trends Genet. 16:182–187. 2000. View Article : Google Scholar : PubMed/NCBI
|
9.
|
Wilson M and Koopman P: Matching SOX:
partner proteins and co-factors of the SOX family of
transcriptional regulators. Curr Opin Genet Dev. 12:441–446. 2002.
View Article : Google Scholar : PubMed/NCBI
|
10.
|
Hussenet T, Dali S, Exinger J, et al: SOX2
is an oncogene activated by recurrent 3q26.3 amplifications in
human lung squamous cell carcinomas. PLoS One. 5:e89602010.
View Article : Google Scholar : PubMed/NCBI
|
11.
|
Bass AJ, Watanabe H, Mermel CH, et al:
SOX2 is an amplified lineage-survival oncogene in lung and
esophageal squamous cell carcinomas. Nat Genet. 41:1238–1242. 2009.
View Article : Google Scholar : PubMed/NCBI
|
12.
|
Chen Y, Shi L, Zhang L, et al: The
molecular mechanism governing the oncogenic potential of SOX2 in
breast cancer. J Biol Chem. 283:17969–17978. 2008. View Article : Google Scholar : PubMed/NCBI
|
13.
|
Otsubo T, Akiyama Y, Yanagihara K and
Yuasa Y: SOX2 is frequently downregulated in gastric cancers and
inhibits cell growth through cell-cycle arrest and apoptosis. Br J
Cancer. 98:824–831. 2008. View Article : Google Scholar : PubMed/NCBI
|
14.
|
Hay N and Sonenberg N: Upstream and
downstream of mTOR. Genes Dev. 18:1926–1945. 2004. View Article : Google Scholar
|
15.
|
Rosenwald IB, Chen JJ, Wang S, Savas L,
London IM and Pullman J: Upregulation of protein synthesis
initiation factor eIF-4E is an early event during colon
carcinogenesis. Oncogene. 18:2507–2517. 1999. View Article : Google Scholar : PubMed/NCBI
|
16.
|
Burnett PE, Barrow RK, Cohen NA, Snyder SH
and Sabatini DM: RAFT1 phosphorylation of the translational
regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA.
95:1432–1437. 1998. View Article : Google Scholar : PubMed/NCBI
|
17.
|
Brunn GJ, Hudson CC, Sekulic A, et al:
Phosphorylation of the translational repressor PHAS-I by the
mammalian target of rapamycin. Science. 277:99–101. 1997.
View Article : Google Scholar : PubMed/NCBI
|
18.
|
Easton JB and Houghton PJ: mTOR and cancer
therapy. Oncogene. 25:6436–6446. 2006. View Article : Google Scholar : PubMed/NCBI
|
19.
|
Sengupta S, Peterson TR and Sabatini DM:
Regulation of the mTOR complex 1 pathway by nutrients, growth
factors, and stress. Mol Cell. 40:310–322. 2010. View Article : Google Scholar : PubMed/NCBI
|
20.
|
Bai X and Jiang Y: Key factors in mTOR
regulation. Cell Mol Life Sci. 67:239–253. 2010. View Article : Google Scholar : PubMed/NCBI
|
21.
|
Liu J, Li M, Song B, et al: Metformin
inhibits renal cell carcinoma in vitro and in vivo xenograft. Urol
Oncol. 31:264–270. 2013. View Article : Google Scholar : PubMed/NCBI
|
22.
|
Wen ZH, Su YC, Lai PL, et al: Critical
role of arachidonic acid-activated mTOR signaling in breast
carcinogenesis and angiogenesis. Oncogene. 32:160–170. 2013.
View Article : Google Scholar : PubMed/NCBI
|
23.
|
Fang X, Yu W, Li L, et al: ChIP-seq and
functional analysis of the SOX2 gene in colorectal cancers. OMICS.
14:369–384. 2010. View Article : Google Scholar
|
24.
|
Gera JF, Mellinghoff IK, Shi Y, et al: AKT
activity determines sensitivity to mammalian target of rapamycin
(mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J
Biol Chem. 279:2737–2746. 2004. View Article : Google Scholar : PubMed/NCBI
|
25.
|
Hashemolhosseini S, Nagamine Y, Morley SJ,
Desrivieres S, Mercep L and Ferrari S: Rapamycin inhibition of the
G1 to S transition is mediated by effects on cyclin D1 mRNA and
protein stability. J Biol Chem. 273:14424–14429. 1998. View Article : Google Scholar : PubMed/NCBI
|
26.
|
Grewe M, Gansauge F, Schmid RM, Adler G
and Seufferlein T: Regulation of cell growth and cyclin D1
expression by the constitutively active FRAP-p70s6K pathway in
human pancreatic cancer cells. Cancer Res. 59:3581–3587.
1999.PubMed/NCBI
|
27.
|
Law M, Forrester E, Chytil A, et al:
Rapamycin disrupts cyclin/cyclin-dependent kinase/p21/proliferating
cell nuclear antigen complexes and cyclin D1 reverses rapamycin
action by stabilizing these complexes. Cancer Res. 66:1070–1080.
2006. View Article : Google Scholar
|
28.
|
Inoki K, Ouyang H, Zhu T, et al: TSC2
integrates Wnt and energy signals via a coordinated phosphorylation
by AMPK and GSK3 to regulate cell growth. Cell. 126:955–968. 2006.
View Article : Google Scholar : PubMed/NCBI
|
29.
|
Alao JP: The regulation of cyclin D1
degradation: roles in cancer development and the potential for
therapeutic invention. Mol Cancer. 6:242007. View Article : Google Scholar : PubMed/NCBI
|
30.
|
Long KB and Hornick JL: SOX2 is highly
expressed in squamous cell carcinomas of the gastrointestinal
tract. Hum Pathol. 40:1768–1773. 2009. View Article : Google Scholar : PubMed/NCBI
|
31.
|
Gontan C, de Munck A, Vermeij M, Grosveld
F, Tibboel D and Rottier R: Sox2 is important for two crucial
processes in lung development: branching morphogenesis and
epithelial cell differentiation. Dev Biol. 317:296–309. 2008.
View Article : Google Scholar : PubMed/NCBI
|