Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review)

  • Authors:
    • Salvatore Santo Signorelli
    • Valerio Fiore
    • Grazia Malaponte
  • View Affiliations

  • Published online on: February 13, 2014     https://doi.org/10.3892/ijmm.2014.1657
  • Pages: 777-783
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Abstract

Peripheral arterial disease (PAD) is a manifestation of atherosclerotic vascular disease and is often associated with other comorbidities, such as hypertension, diabetes and dyslipidemia. An increasing body of evidence supports the notion that inflammation plays an important role in the development and progression of PAD. A number of studies have investigated the association of various acute phase proteins, particularly C-reactive protein (CRP), with PAD. Apart from CRP, other circulating biomarkers, such as matrix metalloproteinases (MMPs), selectins and interleukin (IL)-1, IL-2, IL-6, IL-8 and IL-10 have been considered to play a role in the development of PAD. In this review, the role of these circulating biomarkers in PAD is discussed. Current data indicate that the appropriate use of biomarkers in patients with PAD may contribute to an early diagnosis, an enhanced knowledge of the developmental process of the disease, as well as to the subsequent improvement of current therapies and to the development of new ones.
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2014-April
Volume 33 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Signorelli SS, Fiore V and Malaponte G: Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review). Int J Mol Med 33: 777-783, 2014.
APA
Signorelli, S.S., Fiore, V., & Malaponte, G. (2014). Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review). International Journal of Molecular Medicine, 33, 777-783. https://doi.org/10.3892/ijmm.2014.1657
MLA
Signorelli, S. S., Fiore, V., Malaponte, G."Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review)". International Journal of Molecular Medicine 33.4 (2014): 777-783.
Chicago
Signorelli, S. S., Fiore, V., Malaponte, G."Inflammation and peripheral arterial disease: The value of circulating biomarkers (Review)". International Journal of Molecular Medicine 33, no. 4 (2014): 777-783. https://doi.org/10.3892/ijmm.2014.1657