Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy

  • Authors:
    • Saiko Wakabayashi
    • Keisuke Yamaguchi
    • Seiichiro Kumakura
    • Taisuke Murakami
    • Akimasa Someya
    • Yoshiaki Kajiyama
    • Isao Nagaoka
    • Eiichi Inada
  • View Affiliations

  • Published online on: April 29, 2014     https://doi.org/10.3892/ijmm.2014.1762
  • Pages: 137-144
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Abstract

Post-operative pulmonary complications such as pneumonia, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are closely associated with morbidity and mortality after esophagectomy. One lung ventilation (OLV) is commonly used during esophagectomy. However, the effect of the anesthetic agents on the inflammatory response induced by OLV has yet to be evaluated, particularly during esophagectomy, which causes several complications in the lung. The aim of the present study was to determine the effects of anesthetic agents, such as sevoflurane or propofol, on the inflammatory reactions at the airway. Twenty patients undergoing esophagectomy were randomized to receive either sevoflurane (n=10) or propofol (n=10) as a main anesthetic agent. Epithelial lining fluid (ELF) was obtained from ventilated‑dependent lung (DL) and collapsed non-dependent lung (NDL) by a bronchoscopic microsampling method. The levels of inflammatory cytokines and chemokine [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-12p70] in the ELF were measured using multiplexed bead-based immunoassays before and after OLV. The results indicated that the levels of IL-6 in ELF were significantly increased in both the ventilated DL and collapsed NDL after OLV compared with the levels prior to OLV in the sevoflurane group. By contrast, there was no significant change in the IL-6 levels in the propofol group in the ventilated DL and collapsed NDL before and after OLV. Similarly, IL-8 levels were markedly increased in the ventilated DL and collapsed NDL after OLV compared with those before OLV in the sevoflurane group, whereas there was no significant change in IL-8 levels in the propofol group in the ventilated DL and collapsed NDL before and after OLV. In contrast to the changes in IL-6 and IL-8 levels, levels of IL-10, an anti-inflammatory cytokine, were not obviously changed in both the ventilated DL and collapsed NDL before and after OLV in the sevoflurane group. However, IL-10 levels in the propofol group were increased in the ventilated DL and collapsed NDL after OLV compared with those before OLV. Of note, the levels of TNF-α, IL-1β and IL-12p70 in ELF were below the detection limits. These observations suggested that propofol anesthesia more potently suppresses the surgical stress-induced inflammatory perturbation at the local milieu of the airway during esophagectomy compared with sevoflurane anesthesia.
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July-2014
Volume 34 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wakabayashi S, Yamaguchi K, Kumakura S, Murakami T, Someya A, Kajiyama Y, Nagaoka I and Inada E: Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy . Int J Mol Med 34: 137-144, 2014.
APA
Wakabayashi, S., Yamaguchi, K., Kumakura, S., Murakami, T., Someya, A., Kajiyama, Y. ... Inada, E. (2014). Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy . International Journal of Molecular Medicine, 34, 137-144. https://doi.org/10.3892/ijmm.2014.1762
MLA
Wakabayashi, S., Yamaguchi, K., Kumakura, S., Murakami, T., Someya, A., Kajiyama, Y., Nagaoka, I., Inada, E."Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy ". International Journal of Molecular Medicine 34.1 (2014): 137-144.
Chicago
Wakabayashi, S., Yamaguchi, K., Kumakura, S., Murakami, T., Someya, A., Kajiyama, Y., Nagaoka, I., Inada, E."Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy ". International Journal of Molecular Medicine 34, no. 1 (2014): 137-144. https://doi.org/10.3892/ijmm.2014.1762