Interaction between ingested nutrients and gut endocrine cells in patients with irritable bowel syndrome (Review)
- Authors:
- Magdy El-Salhy
- Odd Helge Gilja
- Doris Gundersen
- Jan G. Hatlebakk
- Trygve Hausken
-
Affiliations: Section of Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Stord, Norway, Section of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Department of Research, Helse-Fonna, Haugesund, Norway - Published online on: June 17, 2014 https://doi.org/10.3892/ijmm.2014.1811
- Pages: 363-371
-
Copyright: © El-Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
This article is mentioned in:
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|
El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: diagnosis, pathogenesis and treatment options. Nova Science Publishers Inc.; New York: 2012 | |
|
Thompson WG: A world view of IBS. Irritable Bowel Syndrome. Camilleri M and Spiller RC: Saunders; Philadelphia and London: pp. 17–26. 2002 | |
|
Agreus L, Svardsudd K, Nyren O and Tibblin G: Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology. 109:671–680. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson WG, Irvine EJ, Pare P, Ferrazzi S and Rance L: Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire. Dig Dis Sci. 47:225–235. 2002. View Article : Google Scholar | |
|
Kennedy TM, Jones RH, Hungin AP, O’Flanagan H and Kelly P: Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population. Gut. 43:770–774. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Drossman DA, Li Z, Andruzzi E, et al: U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 38:1569–1580. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Talley NJ, Gabriel SE, Harmsen WS, Zinsmeister AR and Evans RW: Medical costs in community subjects with irritable bowel syndrome. Gastroenterology. 109:1736–1741. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Hungin AP, Whorwell PJ, Tack J and Mearin F: The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects. Aliment Pharmacol Ther. 17:643–650. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Jones R and Lydeard S: Irritable bowel syndrome in the general population. BMJ. 304:87–90. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Bordie AK: Functional disorders of the colon. J Indian Med Assoc. 58:451–456. 1972.PubMed/NCBI | |
|
O’Keefe EA, Talley NJ, Zinsmeister AR and Jacobsen SJ: Bowel disorders impair functional status and quality of life in the elderly: a population-based study. J Gerontol A Biol Sci Med Sci. 50:M184–M189. 1995.PubMed/NCBI | |
|
Everhart JE and Renault PF: Irritable bowel syndrome in office-based practice in the United States. Gastroenterology. 100:998–1005. 1991.PubMed/NCBI | |
|
Wilson S, Roberts L, Roalfe A, Bridge P and Singh S: Prevalence of irritable bowel syndrome: a community survey. Br J Gen Pract. 54:495–502. 2004.PubMed/NCBI | |
|
Quigley EM, Locke GR, Mueller-Lissner S, et al: Prevalence and management of abdominal cramping and pain: a multinational survey. Aliment Pharmacol Ther. 24:411–419. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Harvey RF, Salih SY and Read AE: Organic and functional disorders in 2000 gastroenterology outpatients. Lancet. 1:632–634. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
Spiller R, Aziz Q, Creed F, et al: Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut. 56:1770–1798. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F and Spiller RC: Functional bowel disorders. Gastroenterology. 130:1480–1491. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson WG and Heaton KW: Functional bowel disorders in apparently healthy people. Gastroenterology. 79:283–288. 1980.PubMed/NCBI | |
|
Miller V, Whitaker K, Morris JA and Whorwell PJ: Gender and irritable bowel syndrome: the male connection. J Clin Gastroenterol. 38:558–560. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Whitehead WE, Burnett CK, Cook EW III and Taub E: Impact of irritable bowel syndrome on quality of life. Dig Dis Sci. 41:2248–2253. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Gralnek IM, Hays RD, Kilbourne A, Naliboff B and Mayer EA: The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology. 119:654–660. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M: Irritable bowel syndrome: diagnosis and pathogenesis. World J Gastroenterol. 18:5151–5163. 2012. | |
|
Simren M, Mansson A, Langkilde AM, et al: Food-related gastrointestinal symptoms in the irritable bowel syndrome. Digestion. 63:108–115. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Nanda R, James R, Smith H, Dudley CR and Jewell DP: Food intolerance and the irritable bowel syndrome. Gut. 30:1099–1104. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Bohn L, Storsrud S, Tornblom H, Bengtsson U and Simren M: Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life. Am J Gastroenterol. 108:634–641. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Jarrett M, Heitkemper MM, Bond EF and Georges J: Comparison of diet composition in women with and without functional bowel disorder. Gastroenterol Nurs. 16:253–258. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Saito YA, Locke GR III, Weaver AL, Zinsmeister AR and Talley NJ: Diet and functional gastrointestinal disorders: a population-based case-control study. Am J Gastroenterol. 100:2743–2748. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Williams EA, Nai X and Corfe BM: Dietary intakes in people with irritable bowel syndrome. BMC Gastroenterol. 11:92011. View Article : Google Scholar : PubMed/NCBI | |
|
Ostgaard H, Hausken T, Gundersen D and El-Salhy M: Diet and effects of diet management on quality of life and symptoms in patients with irritable bowel syndrome. Mol Med Rep. 5:1382–1390. 2012.PubMed/NCBI | |
|
Böhn L, Störsrud S and Simrén M: Nutrient intake in patients with irritable bowel syndrome compared with the general population. Neurogastroenterol Motil. 25:23-e212013.PubMed/NCBI | |
|
Ligaarden SC, Lydersen S and Farup PG: Diet in subjects with irritable bowel syndrome: a cross-sectional study in the general population. BMC Gastroenterol. 12:612012. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Ostgaard H, Gundersen D, Hatlebakk JG and Hausken T: The role of diet in the pathogenesis and management of irritable bowel syndrome (Review). Int J Mol Med. 29:723–731. 2012.PubMed/NCBI | |
|
Dizdar V, Spiller R, Singh G, et al: Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther. 31:883–891. 2010.PubMed/NCBI | |
|
Monsbakken KW, Vandvik PO and Farup PG: Perceived food intolerance in subjects with irritable bowel syndrome - etiology, prevalence and consequences. Eur J Clin Nutr. 60:667–672. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Vesa TH, Seppo LM, Marteau PR, Sahi T and Korpela R: Role of irritable bowel syndrome in subjective lactose intolerance. Am J Clin Nutr. 67:710–715. 1998.PubMed/NCBI | |
|
Geissler C: Human Nutrition. Geissler C and Powers H: Elsevier; Churchill Livingstone: 2005 | |
|
Wald A and Rakel D: Behavioral and complementary approaches for the treatment of irritable bowel syndrome. Nutr Clin Pract. 23:284–292. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Heizer WD, Southern S and McGovern S: The role of diet in symptoms of irritable bowel syndrome in adults: a narrative review. J Am Diet Assoc. 109:1204–1214. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Morcos A, Dinan T and Quigley EM: Irritable bowel syndrome: role of food in pathogenesis and management. J Dig Dis. 10:237–246. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Eswaran S, Tack J and Chey WD: Food: the forgotten factor in the irritable bowel syndrome. Gastroenterol Clin North Am. 40:141–162. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Austin GL, Dalton CB, Hu Y, et al: A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 7:706–708. e7012009. View Article : Google Scholar : PubMed/NCBI | |
|
Barrett JS and Gibson PR: Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals? Therap Adv Gastroenterol. 5:261–268. 2012. View Article : Google Scholar | |
|
Barrett JS: Extending our knowledge of fermentable, short-chain carbohydrates for managing gastrointestinal symptoms. Nutr Clin Pract. 28:300–306. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Biesiekierski JR, Rosella O, Rose R, et al: Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals. J Hum Nutr Diet. 24:154–176. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
de Roest RH, Dobbs BR, Chapman BA, et al: The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study. Int J Clin Pract. 67:895–903. 2013.PubMed/NCBI | |
|
Staudacher HM, Whelan K, Irving PM and Lomer MC: Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome. J Hum Nutr Diet. 24:487–495. 2011. View Article : Google Scholar | |
|
Bijkerk CJ, Muris JW, Knottnerus JA, Hoes AW and de Wit NJ: Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther. 19:245–251. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Ford AC, Talley NJ, Spiegel BM, et al: Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ. 337:a23132008. View Article : Google Scholar : PubMed/NCBI | |
|
Francis CY and Whorwell PJ: Bran and irritable bowel syndrome: time for reappraisal. Lancet. 344:39–40. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Bijkerk CJ, de Wit NJ, Muris JW, Whorwell PJ, Knottnerus JA and Hoes AW: Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial. BMJ. 339:b31542009. View Article : Google Scholar : PubMed/NCBI | |
|
Kassinen A, Krogius-Kurikka L, Makivuokko H, et al: The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 133:24–33. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Si JM, Yu YC, Fan YJ and Chen SJ: Intestinal microecology and quality of life in irritable bowel syndrome patients. World J Gastroenterol. 10:1802–1805. 2004.PubMed/NCBI | |
|
El-Salhy M, Seim I, Chopin L, Gundersen D, Hatlebakk JG and Hausken T: Irritable bowel syndrome: the role of gut neuroendocrine peptides. Front Biosci (Elite Ed). 4:2783–2800. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gunawardene AR, Corfe BM and Staton CA: Classification and functions of enteroendocrine cells of the lower gastrointestinal tract. Int J Exp Pathol. 92:219–231. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
May CL and Kaestner KH: Gut endocrine cell development. Mol Cell Endocrinol. 323:70–75. 2010. View Article : Google Scholar | |
|
Mawe GM, Coates MD and Moses PL: Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther. 23:1067–1076. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Wade PR, Chen J, Jaffe B, Kassem IS, Blakely RD and Gershon MD: Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci. 16:2352–2364. 1996.PubMed/NCBI | |
|
Gershon MD and Tack J: The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. 132:397–414. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Gershon MD: 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes. 20:14–21. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Gershon MD: Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc. 123:268–280. 2012.PubMed/NCBI | |
|
El-Salhy M, Mazzawi T, Gundersen D, Hatlebakk JG and Hausken T: The role of peptide YY in gastrointestinal diseases and disorders (Review). Int J Mol Med. 31:275–282. 2013.PubMed/NCBI | |
|
Dubrasquet M, Bataille D and Gespach C: Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): a potent inhibitor of pentagastrin-stimulated acid secretion in rats. Biosci Rep. 2:391–395. 1982. View Article : Google Scholar : PubMed/NCBI | |
|
Schjoldager BT, Baldissera FG, Mortensen PE, Holst JJ and Christiansen J: Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. Eur J Clin Invest. 18:499–503. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Schjoldager B, Mortensen PE, Myhre J, Christiansen J and Holst JJ: Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions. Dig Dis Sci. 34:1411–1419. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Dakin CL, Small CJ, Batterham RL, et al: Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology. 145:2687–2695. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Wynne K, Park AJ, Small CJ, et al: Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes. 54:2390–2395. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Camilleri M: Peripheral mechanisms in irritable bowel syndrome. N Engl J Med. 367:1626–1635. 2012. View Article : Google Scholar | |
|
Jianu CS, Fossmark R, Syversen U, Hauso O and Waldum HL: A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia. Tumour Biol. 31:373–380. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sandstrom O and El-Salhy M: Ageing and endocrine cells of human duodenum. Mech Ageing Dev. 108:39–48. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M: Ghrelin in gastrointestinal diseases and disorders: a possible role in the pathophysiology and clinical implications (Review). Int J Mol Med. 24:727–732. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Tolhurst G, Reimann F and Gribble FM: Intestinal sensing of nutrients. Handb Exp Pharmacol. 309–335. 2012. View Article : Google Scholar | |
|
Lee J, Cummings BP, Martin E, et al: Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol. 302:R657–R666. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Parker HE, Reimann F and Gribble FM: Molecular mechanisms underlying nutrient-stimulated incretin secretion. Expert Rev Mol Med. 12:e12010. View Article : Google Scholar : PubMed/NCBI | |
|
Raybould HE: Nutrient sensing in the gastrointestinal tract: possible role for nutrient transporters. J Physiol Biochem. 64:349–356. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
San Gabriel A, Nakamura E, Uneyama H and Torii K: Taste, visceral information and exocrine reflexes with glutamate through umami receptors. J Med Invest. 56(Suppl): S209–S217. 2009.PubMed/NCBI | |
|
Rudholm T, Wallin B, Theodorsson E, Naslund E and Hellstrom PM: Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 152:8–12. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Sternini C, Anselmi L and Rozengurt E: Enteroendocrine cells: a site of ‘taste’ in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes. 15:73–78. 2008. | |
|
Sternini C: Taste receptors in the gastrointestinal tract. IV. Functional implications of bitter taste receptors in gastrointestinal chemosensing. Am J Physiol Gastrointest Liver Physiol. 292:G457–G461. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Buchan AM: Nutrient Tasting and Signaling Mechanisms in the Gut III. Endocrine cell recognition of luminal nutrients. Am J Physiol. 277:G1103–G1107. 1999.PubMed/NCBI | |
|
Montero-Hadjadje M, Elias S, Chevalier L, et al: Chromogranin A promotes peptide hormone sorting to mobile granules in constitutively and regulated secreting cells: role of conserved N- and C-terminal peptides. J Biol Chem. 284:12420–12431. 2009. View Article : Google Scholar | |
|
Shooshtarizadeh P, Zhang D, Chich JF, et al: The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity. Regul Pept. 165:102–110. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Rindi G, Inzani F and Solcia E: Pathology of gastrointestinal disorders. Endocrinol Metab Clin North Am. 39:713–727. 2010. View Article : Google Scholar | |
|
Seim I, El-Salhy M, Hausken T, Gundersen D and Chopin L: Ghrelin and the brain-gut axis as a pharmacological target for appetite control. Curr Pharm Des. 18:768–775. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wendelbo I, Mazzawi T and El-Salhy M: Increased serotonin transporter immunoreactivity intensity in the ileum of patients with irritable bowel disease. Mol Med Rep. 9:180–184. 2014.PubMed/NCBI | |
|
El-Salhy M, Wendelbo IH and Gundersen D: Reduced chromogranin A cell density in the ileum of patients with irritable bowel syndrome. Mol Med Rep. 7:1241–1244. 2013.PubMed/NCBI | |
|
El-Salhy M, Vaali K, Dizdar V and Hausken T: Abnormal small-intestinal endocrine cells in patients with irritable bowel syndrome. Dig Dis Sci. 55:3508–3513. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Mazzawi T, Gundersen D and Hausken T: Chromogranin A cell density in the rectum of patients with irritable bowel syndrome. Mol Med Rep. 6:1223–1225. 2012. | |
|
El-Salhy M, Lomholt-Beck B and Hausken T: Chromogranin A as a possible tool in the diagnosis of irritable bowel syndrome. Scand J Gastroenterol. 45:1435–1439. 2010. View Article : Google Scholar | |
|
El-Salhy M, Lillebo E, Reinemo A and Salmelid L: Ghrelin in patients with irritable bowel syndrome. Int J Mol Med. 23:703–707. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Hatlebakk JG, Gundersen D and Hausken T: Endocrine cells in the gastric oxyntic mucosa of patients with irritable bowel syndrome. Dig Dis Sci. 2013. | |
|
El-Salhy M, Gundersen D, Ostgaard H, Lomholt-Beck B, Hatlebakk JG and Hausken T: Low densities of serotonin and peptide YY cells in the colon of patients with irritable bowel syndrome. Dig Dis Sci. 57:873–878. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Chromogranin a cell density as a diagnostic marker for lymphocytic colitis. Dig Dis Sci. 57:3154–3159. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Gundersen D, Hatlebakk JG and Hausken T: Gastric endocrine cells in the oxyntic mucosa ofpatients with irritable bowel syndrome. Dig Dis Sci. 2013. | |
|
El-Salhy M, Gilja OH, Hatlebakk JG and Hausken T: Gastric antral endocrine cells in patients with irritable bowel syndrome. BMC Gastroenterol. 2013. | |
|
El-Salhy M, Gilja OH and Hausken T: Chromogranin A cells in the stomach of patients with sporadic irritable bowel syndrome. Histol Histopathol. 2013. | |
|
Sjolund K, Ekman R and Wierup N: Covariation of plasma ghrelin and motilin in irritable bowel syndrome. Peptides. 31:1109–1112. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wang SH, Dong L, Luo JY, et al: Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome. World J Gastroenterol. 13:6041–6047. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Park JH, Rhee PL, Kim G, et al: Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea-predominant irritable bowel syndrome. Neurogastroenterol Motil. 18:539–546. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Coates MD, Mahoney CR, Linden DR, et al: Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology. 126:1657–1664. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Wendelbo I and Gundersen D: Serotonin and serotonin transporter in the rectum of patients with irritable bowel disease. Mol Med Rep. 8:451–455. 2013.PubMed/NCBI | |
|
Hotoleanu C, Popp R, Trifa AP, Nedelcu L and Dumitrascu DL: Genetic determination of irritable bowel syndrome. World J Gastroenterol. 14:6636–6640. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Whorwell PJ, McCallum M, Creed FH and Roberts CT: Non-colonic features of irritable bowel syndrome. Gut. 27:37–40. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Locke GR III, Zinsmeister AR, Talley NJ, Fett SL and Melton LJ III: Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc. 75:907–912. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Kalantar JS, Locke GR III, Zinsmeister AR, Beighley CM and Talley NJ: Familial aggregation of irritable bowel syndrome: a prospective study. Gut. 52:1703–1707. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kanazawa M, Endo Y, Whitehead WE, Kano M, Hongo M and Fukudo S: Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Dig Dis Sci. 49:1046–1053. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Morris-Yates A, Talley NJ, Boyce PM, Nandurkar S and Andrews G: Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol. 93:1311–1317. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ and Corey LA: Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology. 121:799–804. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Lembo A, Zaman M, Jones M and Talley NJ: Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study. Aliment Pharmacol Ther. 25:1343–1350. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wojczynski MK, North KE, Pedersen NL and Sullivan PF: Irritable bowel syndrome: a co-twin control analysis. Am J Gastroenterol. 102:2220–2229. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Bengtson MB, Ronning T, Vatn MH and Harris JR: Irritable bowel syndrome in twins: genes and environment. Gut. 55:1754–1759. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Mohammed I, Cherkas LF, Riley SA, Spector TD and Trudgill NJ: Genetic influences in irritable bowel syndrome: a twin study. Am J Gastroenterol. 100:1340–1344. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Akiho H, Ihara E and Nakamura K: Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. World J Gastrointest Pathophysiol. 1:97–105. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wouters MM and Boeckxstaens GE: Neuroimmune mechanisms in functional bowel disorders. Neth J Med. 69:55–61. 2011.PubMed/NCBI | |
|
Kuwahara A, Kuramoto H and Kadowaki M: 5-HT activates nitric oxide-generating neurons to stimulate chloride secretion in guinea pig distal colon. Am J Physiol. 275:G829–G834. 1998.PubMed/NCBI | |
|
Gershon MD: Plasticity in serotonin control mechanisms in the gut. Curr Opin Pharmacol. 3:600–607. 2003. View Article : Google Scholar | |
|
Zar S, Benson MJ and Kumar D: Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol. 100:1550–1557. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Zar S, Kumar D and Benson MJ: Food hypersensitivity and irritable bowel syndrome. Aliment Pharmacol Ther. 15:439–449. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Park MI and Camilleri M: Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia? A systematic review. Neurogastroenterol Motil. 18:595–607. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Uz E, Turkay C, Aytac S and Bavbek N: Risk factors for irritable bowel syndrome in Turkish population: role of food allergy. J Clin Gastroenterol. 41:380–383. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Dainese R, Galliani EA, De Lazzari F, Di Leo V and Naccarato R: Discrepancies between reported food intolerance and sensitization test findings in irritable bowel syndrome patients. Am J Gastroenterol. 94:1892–1897. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Bischoff S and Crowe SE: Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology. 128:1089–1113. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Murch S: Allergy and intestinal dysmotility--evidence of genuine causal linkage? Curr Opin Gastroenterol. 22:664–668. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Gui XY: Mast cells: a possible link between psychological stress, enteric infection, food allergy and gut hypersensitivity in the irritable bowel syndrome. J Gastroenterol Hepatol. 13:980–989. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Teufel M, Biedermann T, Rapps N, et al: Psychological burden of food allergy. World J Gastroenterol. 13:3456–3465. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Walker MM and Talley NJ: Functional gastrointestinal disorders and the potential role of eosinophils. Gastroenterol Clin North Am. 37:383–395. vi2008. View Article : Google Scholar : PubMed/NCBI | |
|
Petitpierre M, Gumowski P and Girard JP: Irritable bowel syndrome and hypersensitivity to food. Ann Allergy. 54:538–540. 1985.PubMed/NCBI | |
|
Tobin MC, Moparty B, Farhadi A, DeMeo MT, Bansal PJ and Keshavarzian A: Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol. 100:49–53. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Atkinson W, Sheldon TA, Shaath N and Whorwell PJ: Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 53:1459–1464. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Whorwell PJ: The growing case for an immunological component to irritable bowel syndrome. Clin Exp Allergy. 37:805–807. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Hunter JO: Food elimination in IBS: the case for IgG testing remains doubtful. Gut. 54:1203author reply 1203. 2005.PubMed/NCBI | |
|
Beyer K and Teuber SS: Food allergy diagnostics: scientific and unproven procedures. Curr Opin Allergy Clin Immunol. 5:261–266. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Choung RS, Branda ME, Chitkara D, et al: Longitudinal direct medical costs associated with constipation in women. Aliment Pharmacol Ther. 33:251–260. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ortolani C, Bruijnzeel-Koomen C, Bengtsson U, et al: Controversial aspects of adverse reactions to food. European Academy of Allergology and Clinical Immunology (EAACI) Reactions to Food Subcommittee. Allergy. 54:27–45. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Frissora CL and Koch KL: Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Curr Gastroenterol Rep. 7:264–271. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Lomholt-Beck B and Gundersen D: The prevalence of celiac disease in patients with irritable bowel syndrome. Mol Med Rep. 4:403–405. 2011.PubMed/NCBI | |
|
Catassi C, Kryszak D, Louis-Jacques O, et al: Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol. 102:1454–1460. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Fasano A, Berti I, Gerarduzzi T, et al: Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 163:286–292. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
van der Wouden EJ, Nelis GF and Vecht J: Screening for coeliac disease in patients fulfilling the Rome II criteria for irritable bowel syndrome in a secondary care hospital in The Netherlands: a prospective observational study. Gut. 56:444–445. 2007.PubMed/NCBI | |
|
Locke GR III, Murray JA, Zinsmeister AR, Melton LJ III and Talley NJ: Celiac disease serology in irritable bowel syndrome and dyspepsia: a population-based case-control study. Mayo Clin Proc. 79:476–482. 2004. View Article : Google Scholar | |
|
Hin H, Bird G, Fisher P, Mahy N and Jewell D: Coeliac disease in primary care: case finding study. BMJ. 318:164–167. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Shahbazkhani B, Forootan M, Merat S, et al: Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment Pharmacol Ther. 18:231–235. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Korkut E, Bektas M, Oztas E, Kurt M, Cetinkaya H and Ozden A: The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome. Eur J Intern Med. 21:389–392. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sanders DS, Patel D, Stephenson TJ, et al: A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol. 15:407–413. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Verdu EF, Armstrong D and Murray JA: Between celiac disease and irritable bowel syndrome: the ‘no man’s land’ of gluten sensitivity. Am J Gastroenterol. 104:1587–1594. 2009. | |
|
Wahnschaffe U, Schulzke JD, Zeitz M and Ullrich R: Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 5:844–850; quiz 769. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Carroccio A, Mansueto P, Iacono G, et al: Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol. 107:1898–1906; quiz 1907. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Aziz I and Sanders DS: Emerging concepts: from coeliac disease to non-coeliac gluten sensitivity. Proc Nutr Soc. 71:576–580. 2012. View Article : Google Scholar | |
|
Newnham ED: Does gluten cause gastrointestinal symptoms in subjects without coeliac disease? J Gastroenterol Hepatol. 26(Suppl 3): S132–S134. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG and Gibson PR: No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 145:320–328. e3232013. View Article : Google Scholar | |
|
Mazzawi T, Hausken T, Gundersen D and El-Salhy M: Effects of dietary guidance on the symptoms, quality of life and habitual dietary intake of patients with irritable bowel syndrome. Mol Med Rep. 8:845–852. 2013.PubMed/NCBI | |
|
El-Salhy M, Lilbo E, Reinemo A, Salmeøid L and Hausken T: Effects of a health program comprising reassurance, diet management, probiotic administration and regular exercise on symptoms and quality of life in patients with irritable bowel syndrome. Gastroenterol Insights. 2:21–26. 2010. | |
|
Posserud I, Syrous A, Lindstrom L, Tack J, Abrahamsson H and Simren M: Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology. 133:1113–1123. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ritchie J: Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut. 14:125–132. 1973. View Article : Google Scholar : PubMed/NCBI | |
|
Mertz H, Naliboff B, Munakata J, Niazi N and Mayer EA: Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology. 109:40–52. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Whitehead WE and Palsson OS: Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception. Gastroenterology. 115:1263–1271. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Whitehead WE, Holtkotter B, Enck P, et al: Tolerance for rectosigmoid distention in irritable bowel syndrome. Gastroenterology. 98:1187–1192. 1990.PubMed/NCBI | |
|
Bouin M, Plourde V, Boivin M, et al: Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology. 122:1771–1777. 2002. View Article : Google Scholar | |
|
Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L and Frexinos J: Evaluation of colonic sensory thresholds in IBS patients using a barostat. Definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci. 39:449–457. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Camilleri M, McKinzie S, Busciglio I, et al: Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 6:772–781. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Costantini M, Sturniolo GC, Zaninotto G, et al: Altered esophageal pain threshold in irritable bowel syndrome. Dig Dis Sci. 38:206–212. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Trimble KC, Farouk R, Pryde A, Douglas S and Heading RC: Heightened visceral sensation in functional gastrointestinal disease is not site-specific. Evidence for a generalized disorder of gut sensitivity. Dig Dis Sci. 40:1607–1613. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Zighelboim J, Talley NJ, Phillips SF, Harmsen WS and Zinsmeister AR: Visceral perception in irritable bowel syndrome. Rectal and gastric responses to distension and serotonin type 3 antagonism. Dig Dis Sci. 40:819–827. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Accarino AM, Azpiroz F and Malagelada JR: Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome. Gastroenterology. 108:636–643. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Kanazawa M, Hongo M and Fukudo S: Visceral hypersensitivity in irritable bowel syndrome. J Gastroenterol Hepatol. 26(Suppl 3): S119–S121. 2011. View Article : Google Scholar | |
|
Whorwell PJ, Clouter C and Smith CL: Oesophageal motility in the irritable bowel syndrome. Br Med J (Clin Res Ed). 282:1101–1102. 1981. View Article : Google Scholar : PubMed/NCBI | |
|
Clouse RE and Eckert TC: Gastrointestinal symptoms of patients with esophageal contraction abnormalities. Dig Dis Sci. 31:236–240. 1986. View Article : Google Scholar | |
|
Soffer EE, Scalabrini P, Pope CE II and Wingate DL: Effect of stress on oesophageal motor function in normal subjects and in patients with the irritable bowel syndrome. Gut. 29:1591–1594. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Lind CD: Motility disorders in the irritable bowel syndrome. Gastroenterol Clin North Am. 20:279–295. 1991.PubMed/NCBI | |
|
Lee OY: Asian motility studies in irritable bowel syndrome. J Neurogastroenterol Motil. 16:120–130. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
van Wijk HJ, Smout AJ, Akkermans LM, Roelofs JM and ten Thije OJ: Gastric emptying and dyspeptic symptoms in the irritable bowel syndrome. Scand J Gastroenterol. 27:99–102. 1992.PubMed/NCBI | |
|
Charles F, Phillips SF, Camilleri M and Thomforde GM: Rapid gastric emptying in patients with functional diarrhea. Mayo Clin Proc. 72:323–328. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Caballero-Plasencia AM, Valenzuela-Barranco M, Herrerias-Gutierrez JM and Esteban-Carretero JM: Altered gastric emptying in patients with irritable bowel syndrome. Eur J Nucl Med. 26:404–409. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Portincasa P, Moschetta A, Baldassarre G, Altomare DF and Palasciano G: Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROME II criteria for irritable bowel syndrome. World J Gastroenterol. 9:2293–2299. 2003.PubMed/NCBI | |
|
Stanghellini V, Tosetti C, Barbara G, et al: Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome. Am J Gastroenterol. 97:2738–2743. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Leahy A, Besherdas K, Clayman C, Mason I and Epstein O: Abnormalities of the electrogastrogram in functional gastrointestinal disorders. Am J Gastroenterol. 94:1023–1028. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Evans PR, Bak YT, Shuter B, Hoschl R and Kellow JE: Gastroparesis and small bowel dysmotility in irritable bowel syndrome. Dig Dis Sci. 42:2087–2093. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Nielsen OH, Gjorup T and Christensen FN: Gastric emptying rate and small bowel transit time in patients with irritable bowel syndrome determined with 99mTc-labeled pellets and scintigraphy. Dig Dis Sci. 31:1287–1291. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Narducci F, Bassotti G, Granata MT, et al: Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci. 31:241–246. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Acharya U, Waite N, Howlett P, Tanner AR and Smith CL: Failure to demonstrate altered gastric emptying in irritable bowel syndrome. Dig Dis Sci. 28:889–892. 1983. View Article : Google Scholar |
