Cinnamomum cassia bark produced by solid-state fermentation with Phellinus baumii has the potential to alleviate atopic dermatitis-related symptoms
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- Published online on: November 18, 2014 https://doi.org/10.3892/ijmm.2014.2006
- Pages: 187-194
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Abstract
In order to evaluate whether the aqueous fraction of Cinnamomum cassia produced by solid‑state fermentation with Phellinus baumii (afCc/Pb) inhibits atopic symptoms in vivo, its efficacy was evaluated in an animal model of 2,4‑dinitrofluorobenzene (DNFB)‑induced atopic dermatitis. Immune‑related cells were quantified using hematoxylin and eosin staining, and phenotypic cytokines, enzymes and the expression of other proteins in the animal model were evaluated. The data revealed that afCc/Pb (100 µg/ml) exhibited strong anti‑atopic activity, causing a significant 40% reduction in immune response, as shown by the extent of ear swelling, resulting from a decrease in the number of eosinophils in the skin tissues due to decreased matrix metalloproteinase‑2 and interleukin‑31 expression. These results collectively suggest that afCc/Pb has the potential to alleviate the symptoms of atopic dermatitis in a mouse model of DNFB‑induced atopic dermatitis, and that it may be a valuable bioresource for the cosmetic/cosmeceutical industry.
