Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review)
- Authors:
- Shujiong Feng
- Song Xu
- Zhenzhen Wen
- Yongliang Zhu
-
Affiliations: Laboratory of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310009, P.R. China - Published online on: March 26, 2015 https://doi.org/10.3892/ijmm.2015.2155
- Pages: 1493-1500
This article is mentioned in:
Abstract
Solt LA, Griffin PR and Burris TP: Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr Opin Lipidol. 21:204–211. 2010. View Article : Google Scholar : PubMed/NCBI | |
Becker-André M, André E and DeLamarter JF: Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences. Biochem Biophys Res Commun. 194:1371–1379. 1993. View Article : Google Scholar : PubMed/NCBI | |
Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF and Becker-André M: RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol. 8:757–770. 1994.PubMed/NCBI | |
Jetten AM and Ueda E: Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease. Cell Death Differ. 9:1167–1171. 2002. View Article : Google Scholar : PubMed/NCBI | |
Jetten AM, Kurebayashi S and Ueda E: The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol. 69:205–247. 2001. View Article : Google Scholar : PubMed/NCBI | |
Giguère V: Orphan nuclear receptors: from gene to function. Endocr Rev. 20:689–725. 1999.PubMed/NCBI | |
Gawlas K and Stunnenberg HG: Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. Nucleic Acids Res. 29:3424–3432. 2001. View Article : Google Scholar : PubMed/NCBI | |
Gawlas K and Stunnenberg HG: Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). Biochim Biophys Acta. 1494:236–241. 2000. View Article : Google Scholar : PubMed/NCBI | |
Stehlin C, Wurtz JM, Steinmetz A, et al: X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J. 20:5822–5831. 2001. View Article : Google Scholar : PubMed/NCBI | |
Sullivan AA and Thummel CS: Temporal profiles of nuclear receptor gene expression reveal coordinate transcriptional responses during Drosophila development. Mol Endocrinol. 17:2125–2137. 2003. View Article : Google Scholar : PubMed/NCBI | |
Palli SR, Ladd TR and Retnakaran A: Cloning and characterization of a new isoform of Choristoneura hormone receptor 3 from the spruce budworm. Arch Insect Biochem Physiol. 35:33–44. 1997. View Article : Google Scholar : PubMed/NCBI | |
Hiruma K and Riddiford LM: Differential control of MHR3 promoter activity by isoforms of the ecdysone receptor and inhibitory effects of E75A and MHR3. Dev Biol. 272:510–521. 2004. View Article : Google Scholar : PubMed/NCBI | |
Flores MV, Hall C, Jury A, Crosier K and Crosier P: The zebrafish retinoid-related orphan receptor (ror) gene family. Gene Expr Patterns. 7:535–543. 2007. View Article : Google Scholar : PubMed/NCBI | |
Jetten AM: Recent advances in the mechanisms of action and physiological functions of the retinoid-related orphan receptors (RORs). Curr Drug Targets Inflamm Allergy. 3:395–412. 2004. View Article : Google Scholar : PubMed/NCBI | |
Solt LA, Kojetin DJ and Burris TP: The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis. Future Med Chem. 3:623–638. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M and Castanon-Cervantes O: Localization of a circadian clock in mammalian photoreceptors. FASEB J. 21:3866–3871. 2007. View Article : Google Scholar : PubMed/NCBI | |
Vogel MW, Sinclair M, Qiu D and Fan H: Purkinje cell fate in staggerer mutants: agenesis versus cell death. J Neurobiol. 42:323–337. 2000. View Article : Google Scholar : PubMed/NCBI | |
Ino H: Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system. J Histochem Cytochem. 52:311–323. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kang HS, Angers M, Beak JY, et al: Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics. 31:281–294. 2007. View Article : Google Scholar : PubMed/NCBI | |
André E, Gawlas K and Becker-André M: A novel isoform of the orphan nuclear receptor RORbeta is specifically expressed in pineal gland and retina. Gene. 216:277–283. 1998. View Article : Google Scholar : PubMed/NCBI | |
Chow L, Levine EM and Reh TA: The nuclear receptor transcription factor, retinoid-related orphan receptor beta, regulates retinal progenitor proliferation. Mech Dev. 77:149–164. 1998. View Article : Google Scholar : PubMed/NCBI | |
Baler R, Coon S and Klein DC: Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland. Biochem Biophys Res Commun. 220:975–978. 1996. View Article : Google Scholar : PubMed/NCBI | |
Mühlbauer E, Bazwinsky-Wutschke I, Wolgast S, Labucay K and Peschke E: Differential and day-time dependent expression of nuclear receptors RORalpha, RORbeta, RORgamma and RXRalpha in the rodent pancreas and islet. Mol Cell Endocrinol. 365:129–138. 2013. View Article : Google Scholar | |
André E, Conquet F, Steinmayr M, Stratton SC, Porciatti V and Becker-André M: Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 17:3867–3877. 1998. View Article : Google Scholar : PubMed/NCBI | |
Masana MI, Sumaya IC, Becker-André M and Dubocovich ML: Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol. 292:R2357–R2367. 2007. View Article : Google Scholar : PubMed/NCBI | |
Stehlin-Gaon C, Willmann D, Zeyer D, et al: All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 10:820–825. 2003. View Article : Google Scholar : PubMed/NCBI | |
Wärnmark A, Treuter E, Wright AP and Gustafsson JA: Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation. Mol Endocrinol. 17:1901–1909. 2003. View Article : Google Scholar : PubMed/NCBI | |
Watanabe M, Yanagisawa J, Kitagawa H, et al: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J. 20:1341–1352. 2001. View Article : Google Scholar : PubMed/NCBI | |
Nishihara E, O’Malley BW and Xu J: Nuclear receptor coregulators are new players in nervous system development and function. Mol Neurobiol. 30:307–325. 2004. View Article : Google Scholar | |
Kurebayashi S, Nakajima T, Kim SC, et al: Selective LXXLL peptides antagonize transcriptional activation by the retinoid-related orphan receptor RORgamma. Biochem Biophys Res Commun. 315:919–927. 2004. View Article : Google Scholar : PubMed/NCBI | |
Greiner EF, Kirfel J, Greschik H, et al: Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Proc Natl Acad Sci USA. 97:7160–7165. 2000. View Article : Google Scholar : PubMed/NCBI | |
Heery DM, Hoare S, Hussain S, Parker MG and Sheppard H: Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors. J Biol Chem. 276:6695–6702. 2001. View Article : Google Scholar | |
Torchia J, Rose DW, Inostroza J, et al: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 387:677–684. 1997. View Article : Google Scholar : PubMed/NCBI | |
Glass CK, Rose DW and Rosenfeld MG: Nuclear receptor coactivators. Curr Opin Cell Biol. 9:222–232. 1997. View Article : Google Scholar : PubMed/NCBI | |
Gabriely G, Kama R, Gelin-Licht R and Gerst JE: Different domains of the UBL-UBA ubiquitin receptor, Ddi1/Vsm1, are involved in its multiple cellular roles. Mol Biol Cell. 19:3625–3637. 2008. View Article : Google Scholar : PubMed/NCBI | |
Akashi M and Takumi T: The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol. 12:441–448. 2005. View Article : Google Scholar : PubMed/NCBI | |
Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y and Littman DR: An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol. 5:64–73. 2004. View Article : Google Scholar | |
Liu H, Kim SY, Fu Y, et al: An isoform of retinoid-related orphan receptor beta directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 4:18132013. View Article : Google Scholar | |
Roforth MM, Khosla S and Monroe DG: Identification of Rorβ targets in cultured osteoblasts and in human bone. Biochem Biophys Res Commun. 440:768–773. 2013. View Article : Google Scholar : PubMed/NCBI | |
Davidson B, Abeler VM, Forsund M, et al: Gene expression signatures of primary and metastatic uterine leiomyosarcoma. Hum Pathol. 45:691–700. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jetten AM: Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal. 7:e0032009.PubMed/NCBI | |
Oh EC, Khan N, Novelli E, Khanna H, Strettoi E and Swaroop A: Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Proc Natl Acad Sci USA. 104:1679–1684. 2007. View Article : Google Scholar : PubMed/NCBI | |
Jia L, Oh EC, Ng L, et al: Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci USA. 106:17534–17539. 2009. View Article : Google Scholar : PubMed/NCBI | |
Roforth MM, Liu G, Khosla S and Monroe DG: Examination of nuclear receptor expression in osteoblasts reveals Rorbeta as an important regulator of osteogenesis. J Bone Miner Res. 27:891–901. 2012. View Article : Google Scholar | |
Komori T, Yagi H, Nomura S, et al: Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:755–764. 1997. View Article : Google Scholar : PubMed/NCBI | |
Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I and Rifkin DB: Latent transforming growth factor-beta: structural features and mechanisms of activation. Kidney Int. 51:1376–1382. 1997. View Article : Google Scholar : PubMed/NCBI | |
Risinger JI, Allard J, Chandran U, et al: Gene expression analysis of early stage endometrial cancers reveals unique transcripts associated with grade and histology but not depth of invasion. Front Oncol. 3:1392013. View Article : Google Scholar : PubMed/NCBI | |
Matijevic T and Pavelic J: The dual role of TLR3 in metastatic cell line. Clin Exp Metastasis. 28:701–712. 2011. View Article : Google Scholar : PubMed/NCBI | |
Kimmel AR: An orphan nuclear receptor finds a home. Mol Cell. 37:155–157. 2010. View Article : Google Scholar : PubMed/NCBI | |
McDonald SL and Silver A: The opposing roles of Wnt-5a in cancer. Br J Cancer. 101:209–214. 2009. View Article : Google Scholar : PubMed/NCBI | |
Lee JM, Kim IS, Kim H, et al: RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. Mol Cell. 37:183–195. 2010. View Article : Google Scholar : PubMed/NCBI | |
Gery S and Koeffler HP: The role of circadian regulation in cancer. Cold Spring Harb Symp Quant Biol. 72:459–464. 2007. View Article : Google Scholar | |
Kettner NM, Katchy CA and Fu L: Circadian gene variants in cancer. Ann Med. 46:208–220. 2014. View Article : Google Scholar : PubMed/NCBI | |
Fu L and Kettner NM: The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci. 119:221–282. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ueda HR, Hayashi S, Chen W, et al: System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet. 37:187–192. 2005. View Article : Google Scholar : PubMed/NCBI | |
Shearman LP, Sriram S, Weaver DR, et al: Interacting molecular loops in the mammalian circadian clock. Science. 288:1013–1019. 2000. View Article : Google Scholar : PubMed/NCBI | |
Reick M, Garcia JA, Dudley C and McKnight SL: NPAS2: an analog of clock operative in the mammalian forebrain. Science. 293:506–509. 2001. View Article : Google Scholar : PubMed/NCBI | |
Nakahata Y, Kaluzova M, Grimaldi B, et al: The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 134:329–340. 2008. View Article : Google Scholar : PubMed/NCBI | |
Asher G, Gatfield D, Stratmann M, et al: SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 134:317–328. 2008. View Article : Google Scholar : PubMed/NCBI | |
Rana S and Mahmood S: Circadian rhythm and its role in malignancy. J Circadian Rhythms. 8:32010. View Article : Google Scholar : PubMed/NCBI | |
Pukkala E, Aspholm R, Auvinen A, et al: Cancer incidence among 10,211 airline pilots: a Nordic study. Aviat Space Environ Med. 74:699–706. 2003.PubMed/NCBI | |
Viswanathan AN, Hankinson SE and Schernhammer ES: Night shift work and the risk of endometrial cancer. Cancer Res. 67:10618–10622. 2007. View Article : Google Scholar : PubMed/NCBI | |
Koppes LL, Geuskens GA, Pronk A, Vermeulen RC and de Vroome EM: Night work and breast cancer risk in a general population prospective cohort study in The Netherlands. Eur J Epidemiol. 29:577–584. 2014. View Article : Google Scholar : PubMed/NCBI | |
Schernhammer ES, Laden F, Speizer FE, et al: Night-shift work and risk of colorectal cancer in the nurses’ health study. J Natl Cancer Inst. 95:825–828. 2003. View Article : Google Scholar : PubMed/NCBI | |
Keith LG, Oleszczuk JJ and Laguens M: Circadian rhythm chaos: a new breast cancer marker. Int J Fertil Womens Med. 46:238–247. 2001.PubMed/NCBI | |
Zhu Y, Stevens RG, Hoffman AE, et al: Epigenetic impact of long-term shiftwork: pilot evidence from circadian genes and whole-genome methylation analysis. Chronobiol Int. 28:852–861. 2011. View Article : Google Scholar : PubMed/NCBI | |
Shih MC, Yeh KT, Tang KP, Chen JC and Chang JG: Promoter methylation in circadian genes of endometrial cancers detected by methylation-specific PCR. Mol Carcinog. 45:732–740. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hwang-Verslues WW, Chang PH, Jeng YM, et al: Loss of core-pressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci USA. 110:12331–12336. 2013. View Article : Google Scholar | |
Yang X, Wood PA, Oh EY, Du-Quiton J, Ansell CM and Hrushesky WJ: Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm. Breast Cancer Res Treat. 117:423–431. 2009. View Article : Google Scholar | |
Gery S, Virk RK, Chumakov K, Yu A and Koeffler HP: The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene. 26:7916–7920. 2007. View Article : Google Scholar : PubMed/NCBI | |
Filipski E and Levi F: Circadian disruption in experimental cancer processes. Integr Cancer Ther. 8:298–302. 2009. View Article : Google Scholar | |
Kumaki Y, Ukai-Tadenuma M, Uno KD, et al: Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock. Proc Natl Acad Sci USA. 105:14946–14951. 2008. View Article : Google Scholar : PubMed/NCBI |