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Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress

  • Authors:
    • Yingxin Zou
    • Yuxiang Liu
    • Minghua Ruan
    • Xu Feng
    • Jiachun Wang
    • Zhiyong Chu
    • Zesheng Zhang

  • View Affiliations

  • Published online on: July 30, 2015     https://doi.org/10.3892/ijmm.2015.2296
  • Pages: 939-946

  • Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated the effect of Cordyceps sinensis oral liquid (CSOL) on the lifespan of Drosophila melanogaster (fruit fly). Following the lifelong treatment of fruit flies with CSOL, lifespan was examined. The activity of copper-zinc-containing superoxide dismutase 1 (SOD1), manganese-containing superoxide dismutase 2 (SOD2) and catalase (CAT), as well as the lipofuscin (LF) content were determined. The mRNA levels of SOD1, SOD2 and CAT were quantified by qPCR. Hydrogen peroxide (H2O2) and paraquat were used to mimic the effects of damage caused by acute oxidative stress. D-galactose was used to mimic chronic pathological aging. CSOL significantly prolonged the lifespan of the fruit flies under physiological conditions. The activity of SOD1 and CAT was upregulated, and LF accumulation was inhibited by CSOL. CSOL had no effect on the transcriptional levels (mRNA) of these enzymes. The survival time of the fruit flies which were negatively affected by exposure to H2O2 or paraquat was significantly prolonged by CSOL. In fruit flies pathologically aged by epxosure to D-galactose, CSOL also significantly prolonged their lifespan, upregulated the activity of SOD1 and CAT, and inhibited LF accumulation. The findings of our study indicate that CSOL prolongs the lifespan of fruit flies through an anti-oxidative stress pathway involving the upregulation of SOD1 and CAT activity and the inhibition of LF accumulation. CSOL may thus be explored as a novel agent for slowing the human aging process.
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October-2015
Volume 36 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 12.3
  • CiteScore Rank: Q1: #28/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 1.022
  • SCImago Journal Rank (SJR): 1.167
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Spandidos Publications style
Zou Y, Liu Y, Ruan M, Feng X, Wang J, Chu Z and Zhang Z: Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. Int J Mol Med 36: 939-946, 2015.
APA
Zou, Y., Liu, Y., Ruan, M., Feng, X., Wang, J., Chu, Z., & Zhang, Z. (2015). Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress. International Journal of Molecular Medicine, 36, 939-946. https://doi.org/10.3892/ijmm.2015.2296
MLA
Zou, Y., Liu, Y., Ruan, M., Feng, X., Wang, J., Chu, Z., Zhang, Z."Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress". International Journal of Molecular Medicine 36.4 (2015): 939-946.
Chicago
Zou, Y., Liu, Y., Ruan, M., Feng, X., Wang, J., Chu, Z., Zhang, Z."Cordyceps sinensis oral liquid prolongs the lifespan of the fruit fly, Drosophila melanogaster, by inhibiting oxidative stress". International Journal of Molecular Medicine 36, no. 4 (2015): 939-946. https://doi.org/10.3892/ijmm.2015.2296