Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study

  • Authors:
    • Naishun Liao
    • Fan Pan
    • Yingchao Wang
    • Youshi Zheng
    • Bo Xu
    • Wenwei Chen
    • Yunzhen Gao
    • Zhixiong Cai
    • Xiaolong Liu
    • Jingfeng Liu
  • View Affiliations

  • Published online on: March 15, 2016     https://doi.org/10.3892/ijmm.2016.2528
  • Pages: 1389-1396
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Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver injury and seriously affects human health. In the present study, we aimed to investigate whether adipose tissue-derived stem cell (ADSC) transplantation in combination with dietary modification was capable of reversing the progression of NAFLD. After establishing a rat model of NAFLD by feeding them a high-fat diet (HFD), ADSCs were transplanted via the portal vein into rats with HFD-induced NAFLD, and simultaneously fed a modified diet. Thereafter, gross liver morphology, the hepatosomatic (HSI) index and indicators of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) were evaluated. Subsequently, the serum levels of total cholesterol (TC), triglycerides (TGs) and fatty acids (FAs) were also assayed. Furthermore, H&E and oil red O staining were used to confirm the pathological effects of NAFLD in the rat livers. Although dietary modification alone caused liver function to recover, ADSC transplantation in combination with dietary modification further decreased the HSI index, the serum levels of ALT, TBIL, TC, TGs, FAs, reduced lipid accumulation to normal levels, and reversed the hepatic pathological changes in the rat livers. Taken together, these findings suggest that ADSC transplantation assists in the reversion of NAFLD by improving liver function and promoting lipid metabolism, thereby exerting hepatoprotective effects. Thus, we suggest that ADSC transplantation is a promising, potential therapeutic strategy for NAFLD treatment.
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May-2016
Volume 37 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Liao N, Pan F, Wang Y, Zheng Y, Xu B, Chen W, Gao Y, Cai Z, Liu X, Liu J, Liu J, et al: Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study. Int J Mol Med 37: 1389-1396, 2016.
APA
Liao, N., Pan, F., Wang, Y., Zheng, Y., Xu, B., Chen, W. ... Liu, J. (2016). Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study. International Journal of Molecular Medicine, 37, 1389-1396. https://doi.org/10.3892/ijmm.2016.2528
MLA
Liao, N., Pan, F., Wang, Y., Zheng, Y., Xu, B., Chen, W., Gao, Y., Cai, Z., Liu, X., Liu, J."Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study". International Journal of Molecular Medicine 37.5 (2016): 1389-1396.
Chicago
Liao, N., Pan, F., Wang, Y., Zheng, Y., Xu, B., Chen, W., Gao, Y., Cai, Z., Liu, X., Liu, J."Adipose tissue-derived stem cells promote the reversion of non-alcoholic fatty liver disease: An in vivo study". International Journal of Molecular Medicine 37, no. 5 (2016): 1389-1396. https://doi.org/10.3892/ijmm.2016.2528