Open Access

Advances in stem cell therapy for cardiovascular disease (Review)

  • Authors:
    • Rongrong Sun
    • Xianchi Li
    • Min Liu
    • Yi Zeng
    • Shuang Chen
    • Peying Zhang
  • View Affiliations

  • Published online on: May 25, 2016     https://doi.org/10.3892/ijmm.2016.2607
  • Pages: 23-29
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular disease constitutes the primary cause of mortality and morbidity worldwide, and represents a group of disorders associated with the loss of cardiac function. Despite considerable advances in the understanding of the pathologic mechanisms of the disease, the majority of the currently available therapies remain at best palliative, since the problem of cardiac tissue loss has not yet been addressed. Indeed, few therapeutic approaches offer direct tissue repair and regeneration, whereas the majority of treatment options aim to limit scar formation and adverse remodeling, while improving myocardial function. Of all the existing therapeutic approaches, the problem of cardiac tissue loss is addressed uniquely by heart transplantation. Nevertheless, alternative options, particularly stem cell therapy, has emerged as a novel and promising approach. This approach involves the transplantation of healthy and functional cells to promote the renewal of damaged cells and repair injured tissue. Bone marrow precursor cells were the first cell type used in clinical studies, and subsequently, preclinical and clinical investigations have been extended to the use of various populations of stem cells. This review addresses the present state of research as regards stem cell therapy for cardiovascular disease.
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July-2016
Volume 38 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Sun R, Li X, Liu M, Zeng Y, Chen S and Zhang P: Advances in stem cell therapy for cardiovascular disease (Review). Int J Mol Med 38: 23-29, 2016.
APA
Sun, R., Li, X., Liu, M., Zeng, Y., Chen, S., & Zhang, P. (2016). Advances in stem cell therapy for cardiovascular disease (Review). International Journal of Molecular Medicine, 38, 23-29. https://doi.org/10.3892/ijmm.2016.2607
MLA
Sun, R., Li, X., Liu, M., Zeng, Y., Chen, S., Zhang, P."Advances in stem cell therapy for cardiovascular disease (Review)". International Journal of Molecular Medicine 38.1 (2016): 23-29.
Chicago
Sun, R., Li, X., Liu, M., Zeng, Y., Chen, S., Zhang, P."Advances in stem cell therapy for cardiovascular disease (Review)". International Journal of Molecular Medicine 38, no. 1 (2016): 23-29. https://doi.org/10.3892/ijmm.2016.2607