Open Access

Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease

  • Authors:
    • Xin-Jie Bao
    • Geng-Chao Wang
    • Fu-Xing Zuo
    • Xue-Yuan Li
    • Jun Wu
    • Guo Chen
    • Wan‑Chen Dou
    • Yi Guo
    • Qin Shen
    • Ren-Zhi Wang
  • View Affiliations

  • Published online on: July 3, 2017     https://doi.org/10.3892/ijmm.2017.3052
  • Pages: 771-783
  • Copyright: © Bao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adult neurogenesis in the subventricular zone (SVZ), as well as in the subgranular zone contributes to brain maintenance and regeneration. In the adult brain, dopamine (DA) can regulate the endogenous neural stem cells within these two regions, while a DA deficit may affect neurogenesis. Notably, the factors that regulate in vivo neurogenesis in these subregions have not yet been fully characterized, particularly following DA depletion. In thi study, we performed RNA sequencing to investigate transcriptomic changes in the SVZ and dentate gyrus (DG) of mice in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). This analysis identified differentially expressed genes which were involved in the regulation of transcription, immune response, extracellular region, cell junction and myelination. These genes partially displayed different temporal profiles of expression, some of which may participate in the metabolic switch related to neurogenesis. Additionally, the mitogen‑activated protein kinase (MAPK) signaling pathway was shown to be been positively regulated in the SVZ, while it was negatively affected in the DG following MPTP administration. Overall, our findings indicate that exposure to MPTP may exert different effects on transcriptome profiling between the SVZ and DG.
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September-2017
Volume 40 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Bao X, Wang G, Zuo F, Li X, Wu J, Chen G, Dou WC, Guo Y, Shen Q, Wang R, Wang R, et al: Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease. Int J Mol Med 40: 771-783, 2017.
APA
Bao, X., Wang, G., Zuo, F., Li, X., Wu, J., Chen, G. ... Wang, R. (2017). Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease. International Journal of Molecular Medicine, 40, 771-783. https://doi.org/10.3892/ijmm.2017.3052
MLA
Bao, X., Wang, G., Zuo, F., Li, X., Wu, J., Chen, G., Dou, W., Guo, Y., Shen, Q., Wang, R."Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease". International Journal of Molecular Medicine 40.3 (2017): 771-783.
Chicago
Bao, X., Wang, G., Zuo, F., Li, X., Wu, J., Chen, G., Dou, W., Guo, Y., Shen, Q., Wang, R."Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease". International Journal of Molecular Medicine 40, no. 3 (2017): 771-783. https://doi.org/10.3892/ijmm.2017.3052