Melanogenesis in uveal melanoma cells: Effect of argan oil

Corrigendum in: /10.3892/ijmm.2023.5308

  • Authors:
    • Nunzia Caporarello
    • Melania Olivieri
    • Martina Cristaldi
    • Dario Rusciano
    • Gabriella Lupo
    • Carmelina Daniela Anfuso
  • View Affiliations

  • Published online on: August 23, 2017     https://doi.org/10.3892/ijmm.2017.3104
  • Pages: 1277-1284
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Abstract

The mechanisms underlying cutaneous melanogenesis have been widely studied; however, very little is known about uveal melanogenesis. Melanin is normally produced by uveal melanocytes and gives the color to the iris. A derangement from this normal production may occur, for instance, by iatrogenic events, such as glaucoma therapy with prostaglandins that may enhance cutaneous and iris pigmentation. In this study, we investigated the mechanisms that regulate uveal melanogenesis in human uveal melanoma cells (92.1) and murine cutaneous melanoma cells (B16-F1). In the first part of the study, we compared the effects of known cutaneous pigmenting agents on the B16-F1 and 92.1 cells, showing an opposite response of the two cell lines. Subsequently, using argan oil, a known depigmenting agent for murine cutaneous melanoma cells, on 92.1 cells, we found that in these cells, it also functioned as an inhibitor of melanogenesis and tyrosinase expression. From a molecular perspective, treatment of the 92.1 cells with argan oil decreased melanogenesis-associated transcription factor (MITF) gene expression by inducing MITF phosphorylation at Ser73, thus leading to MITF ubiquitination and disposal. It also led to the downregulation of the extracellular signal-regulated kinase (ERK)1/2 and Akt pathways, also known to be involved in cutaneous melanogenesis, although with an opposing function. Taken together, our data indicate that: ⅰ) some differences exist in the regulation of melanogenesis between cutaneous and uveal melanoma cells; and ⅱ) argan oil exerts a depigmenting effect on 92.1 cells through its action on the ERK1/2 and Akt pathways.
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October-2017
Volume 40 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Caporarello N, Olivieri M, Cristaldi M, Rusciano D, Lupo G and Anfuso CD: Melanogenesis in uveal melanoma cells: Effect of argan oil Corrigendum in /10.3892/ijmm.2023.5308. Int J Mol Med 40: 1277-1284, 2017
APA
Caporarello, N., Olivieri, M., Cristaldi, M., Rusciano, D., Lupo, G., & Anfuso, C.D. (2017). Melanogenesis in uveal melanoma cells: Effect of argan oil Corrigendum in /10.3892/ijmm.2023.5308. International Journal of Molecular Medicine, 40, 1277-1284. https://doi.org/10.3892/ijmm.2017.3104
MLA
Caporarello, N., Olivieri, M., Cristaldi, M., Rusciano, D., Lupo, G., Anfuso, C. D."Melanogenesis in uveal melanoma cells: Effect of argan oil Corrigendum in /10.3892/ijmm.2023.5308". International Journal of Molecular Medicine 40.4 (2017): 1277-1284.
Chicago
Caporarello, N., Olivieri, M., Cristaldi, M., Rusciano, D., Lupo, G., Anfuso, C. D."Melanogenesis in uveal melanoma cells: Effect of argan oil Corrigendum in /10.3892/ijmm.2023.5308". International Journal of Molecular Medicine 40, no. 4 (2017): 1277-1284. https://doi.org/10.3892/ijmm.2017.3104