1
|
Yang S, Chen J, Guo Z, Xu XM, Wang L, Pei
XF, Yang J, Underhill CB and Zhang L: Triptolide inhibits the
growth and metastasis of solid tumors. Mol Cancer Ther. 2:65–72.
2003.PubMed/NCBI
|
2
|
Raab MS, Podar K, Breitkreutz I,
Richardson PG and Anderson KC: Multiple myeloma. Lancet.
374:324–339. 2009. View Article : Google Scholar : PubMed/NCBI
|
3
|
Jemal A, Siegel R, Xu J and Ward E: Cancer
statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI
|
4
|
Kumar SK, Dispenzieri A, Lacy MQ, Gertz
MA, Buadi FK, Pandey S, Kapoor P, Dingli D, Hayman SR, Leung N, et
al: Continued improvement in survival in multiple myeloma: changes
in early mortality and outcomes in older patients. Leukemia.
28:1122–1128. 2014. View Article : Google Scholar :
|
5
|
Kyle RA and Rajkumar SV: Treatment of
multiple myeloma: a comprehensive review. Clin Lymphoma Myeloma.
9:278–288. 2009. View Article : Google Scholar : PubMed/NCBI
|
6
|
Kyle RA: Targeted therapy of multiple
myeloma. Hematology. 17(Suppl 1): 125–128. 2012.
|
7
|
Anderson KC: The 39th David A. Karnofsky
Lecture: bench-to- bedside translation of targeted therapies in
multiple myeloma. J Clin Oncol. 30:445–452. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Kong LY and Tan RX: Artemisinin, a miracle
of traditional Chinese medicine. Nat Prod Rep. 32:1617–1621. 2015.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Ding GS: Important Chinese herbal
remedies. Clin Ther. 9:345–357. 1987.PubMed/NCBI
|
10
|
Chen BJ: Triptolide, a novel
immunosuppressive and anti-inflammatory agent purified from a
Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma.
42:253–265. 2001. View Article : Google Scholar : PubMed/NCBI
|
11
|
Wu R, Li Y, Guo Z, Gong J, Zhu W, Li N and
Li J: Triptolide ameliorates ileocolonic anastomosis inflammation
in IL-10 deficient mice by mechanism involving suppression of
miR-155/SHIP-1 signaling pathway. Mol Immunol. 56:340–346. 2013.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Wei X, Gong J, Zhu J, Wang P, Li N, Zhu W
and Li J: The suppressive effect of triptolide on chronic colitis
and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient
mice. Clin Immunol. 129:211–218. 2008. View Article : Google Scholar : PubMed/NCBI
|
13
|
Qiu D and Kao PN: Immunosuppressive and
anti-inflammatory mechanisms of triptolide, the principal active
diterpenoid from the Chinese medicinal herb Tripterygium wilfordii
Hook. f. Drugs R D. 4:1–18. 2003. View Article : Google Scholar : PubMed/NCBI
|
14
|
Lin N, Liu C, Xiao C, Jia H, Imada K, Wu H
and Ito A: Triptolide, a diterpenoid triepoxide, suppresses
inflammation and cartilage destruction in collagen-induced
arthritis mice. Biochem Pharmacol. 73:136–146. 2007. View Article : Google Scholar
|
15
|
Zhu W, He S, Li Y, Qiu P, Shu M, Ou Y,
Zhou Y, Leng T, Xie J, Zheng X, et al: Anti-angiogenic activity of
triptolide in anaplastic thyroid carcinoma is mediated by targeting
vascular endothelial and tumor cells. Vascul Pharmacol. 52:46–54.
2010. View Article : Google Scholar
|
16
|
Banerjee S, Sangwan V, McGinn O, Chugh R,
Dudeja V, Vickers SM and Saluja AK: Triptolide-induced cell death
in pancreatic cancer is mediated by O-GlcNAc modification of
transcription factor Sp1. J Biol Chem. 288:33927–33938. 2013.
View Article : Google Scholar : PubMed/NCBI
|
17
|
Phillips PA, Dudeja V, McCarroll JA,
Borja-Cacho D, Dawra RK, Grizzle WE, Vickers SM and Saluja AK:
Triptolide induces pancreatic cancer cell death via inhibition of
heat shock protein 70. Cancer Res. 67:9407–9416. 2007. View Article : Google Scholar : PubMed/NCBI
|
18
|
Wu PP, Liu KC, Huang WW, Ma CY, Lin H,
Yang JS and Chung JG: Triptolide induces apoptosis in human adrenal
cancer NCI-H295 cells through a mitochondrial-dependent pathway.
Oncol Rep. 25:551–557. 2011.
|
19
|
Zheng Y, Zhang WJ and Wang XM: Triptolide
with potential medicinal value for diseases of the central nervous
system. CNS Neurosci Ther. 19:76–82. 2013. View Article : Google Scholar
|
20
|
Zhao F, Chen Y, Li R, Liu Y, Wen L and
Zhang C: Triptolide alters histone H3K9 and H3K27 methylation state
and induces G0/G1 arrest and caspase-dependent apoptosis in
multiple myeloma in vitro. Toxicology. 267:70–79. 2010. View Article : Google Scholar
|
21
|
Yinjun L, Jie J and Yungui W: Triptolide
inhibits transcription factor NF-kappaB and induces apoptosis of
multiple myeloma cells. Leuk Res. 29:99–105. 2005. View Article : Google Scholar
|
22
|
Chen Q, Lu Z, Jin Y, Wu Y and Pan J:
Triptolide inhibits Jak2 transcription and induces apoptosis in
human myeloproliferative disorder cells bearing Jak2V617F through
caspase-3-mediated cleavage of Mcl-1. Cancer Lett. 291:246–255.
2010. View Article : Google Scholar
|
23
|
Tang J, Li ZH, Ge SN, Wang W, Mei XP, Wang
W, Zhang T, Xu LX and Li JL: The inhibition of spinal astrocytic
JAK2-STAT3 pathway activation correlates with the analgesic effects
of triptolide in the rat neuropathic pain model. Evid Based
Complement Alternat Med. 2012:1851672012. View Article : Google Scholar
|
24
|
Wang Z, Jin H, Xu R, Mei Q and Fan D:
Triptolide downregulates Rac1 and the JAK/STAT3 pathway and
inhibits colitis-related colon cancer progression. Exp Mol Med.
41:717–727. 2009. View Article : Google Scholar : PubMed/NCBI
|
25
|
Aggarwal BB, Sethi G, Ahn KS, Sandur SK,
Pandey MK, Kunnumakkara AB, Sung B and Ichikawa H: Targeting signal
-transducer-and-activator-of-transcription-3 for prevention and
therapy of cancer: modern target but ancient solution. Ann N Y Acad
Sci. 1091:151–169. 2006. View Article : Google Scholar
|
26
|
Yu H, Kortylewski M and Pardoll D:
Crosstalk between cancer and immune cells: role of STAT3 in the
tumour microenvironment. Nat Rev Immunol. 7:41–51. 2007. View Article : Google Scholar
|
27
|
Zhong Z, Wen Z and Darnell JE Jr: Stat3: a
STAT family member activated by tyrosine phosphorylation in
response to epidermal growth factor and interleukin-6. Science.
264:95–98. 1994. View Article : Google Scholar : PubMed/NCBI
|
28
|
Grandis JR, Drenning SD, Chakraborty A,
Zhou MY, Zeng Q, Pitt AS and Tweardy DJ: Requirement of Stat3 but
not Stat1 activation for epidermal growth factor receptor-mediated
cell growth in vitro. J Clin Invest. 102:1385–1392. 1998.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Zushi S, Shinomura Y, Kiyohara T, Miyazaki
Y, Kondo S, Sugimachi M, Higashimoto Y, Kanayama S and Matsuzawa Y:
STAT3 mediates the survival signal in oncogenic ras-transfected
intestinal epithelial cells. Int J Cancer. 78:326–330. 1998.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Shen Y, Devgan G, Darnell JE Jr and
Bromberg JF: Consti tutively activated Stat3 protects fibroblasts
from serum withdrawal and UV-induced apoptosis and antagonizes the
proapoptotic effects of activated Stat1. Proc Natl Acad Sci USA.
98:1543–1548. 2001. View Article : Google Scholar
|
31
|
Bhattacharya S, Ray RM and Johnson LR:
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents
apoptosis in polyamine-depleted cells. Biochem J. 392:335–344.
2005. View Article : Google Scholar : PubMed/NCBI
|
32
|
Aoki Y, Feldman GM and Tosato G:
Inhibition of STAT3 signaling induces apoptosis and decreases
survivin expression in primary effusion lymphoma. Blood.
101:1535–1542. 2003. View Article : Google Scholar
|
33
|
Yu CL, Meyer DJ, Campbell GS, Larner AC,
Carter-Su C, Schwartz J and Jove R: Enhanced DNA-binding activity
of a Stat3-related protein in cells transformed by the Src
oncoprotein. Science. 269:81–83. 1995. View Article : Google Scholar : PubMed/NCBI
|
34
|
Schreiner SJ, Schiavone AP and Smithgall
TE: Activation of STAT3 by the Src family kinase Hck requires a
functional SH3 domain. J Biol Chem. 277:45680–45687. 2002.
View Article : Google Scholar : PubMed/NCBI
|
35
|
Ihle JN: STATs: signal transducers and
activators of transcription. Cell. 84:331–334. 1996. View Article : Google Scholar : PubMed/NCBI
|
36
|
Chim CS, Fung TK, Cheung WC, Liang R and
Kwong YL: SOCS1 and SHP1 hypermethylation in multiple myeloma:
implications for epigenetic activation of the Jak/STAT pathway.
Blood. 103:4630–4635. 2004. View Article : Google Scholar : PubMed/NCBI
|
37
|
Oka T, Ouchida M, Koyama M, Ogama Y,
Takada S, Nakatani Y, Tanaka T, Yoshino T, Hayashi K, Ohara N, et
al: Gene silencing of the tyrosine phosphatase SHP1 gene by
aberrant methylation in leukemias/lymphomas. Cancer Res.
62:6390–6394. 2002.PubMed/NCBI
|
38
|
Yu H and Jove R: The STATs of cancer - new
molecular targets come of age. Nat Rev Cancer. 4:97–105. 2004.
View Article : Google Scholar : PubMed/NCBI
|
39
|
Weinmann P, Gaehtgens P and Walzog B:
Bcl-Xl- and Bax-alpha-mediated regulation of apoptosis of human
neutrophils via caspase-3. Blood. 93:3106–3115. 1999.PubMed/NCBI
|
40
|
Jin K, Mao XO, Batteur SP, McEachron E,
Leahy A and Greenberg DA: Caspase-3 and the regulation of hypoxic
neuronal death by vascular endothelial growth factor. Neuroscience.
108:351–358. 2001. View Article : Google Scholar : PubMed/NCBI
|
41
|
Chan EW, Cheng SC, Sin FW and Xie Y:
Triptolide induced cytotoxic effects on human promyelocytic
leukemia, T cell lymphoma and human hepatocellular carcinoma cell
lines. Toxicol Lett. 122:81–87. 2001. View Article : Google Scholar : PubMed/NCBI
|
42
|
Chen YW, Lin GJ, Chia WT, Lin CK, Chuang
YP and Sytwu HK: Triptolide exerts anti-tumor effect on oral cancer
and KB cells in vitro and in vivo. Oral Oncol. 45:562–568. 2009.
View Article : Google Scholar : PubMed/NCBI
|
43
|
Tengchaisri T, Chawengkirttikul R,
Rachaphaew N, Reutrakul V, Sangsuwan R and Sirisinha S: Antitumor
activity of triptolide against cholangiocarcinoma growth in vitro
and in hamsters. Cancer Lett. 133:169–175. 1998. View Article : Google Scholar
|
44
|
Pyatt DW, Yang Y, Mehos B, Le A, Stillman
W and Irons RD: Hematotoxicity of the chinese herbal medicine
Tripterygium wilfordii Hook f in CD34-positive human bone marrow
cells. Mol Pharmacol. 57:512–518. 2000.PubMed/NCBI
|
45
|
Schindler C and Darnell JE Jr:
Transcriptional responses to polypeptide ligands: the JAK-STAT
pathway. Annu Rev Biochem. 64:621–651. 1995. View Article : Google Scholar : PubMed/NCBI
|
46
|
Hodge DR, Hurt EM and Farrar WL: The role
of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer.
41:2502–2512. 2005. View Article : Google Scholar : PubMed/NCBI
|
47
|
Chang Q, Bournazou E, Sansone P, Berishaj
M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, et al:
The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and
metastasis. Neoplasia. 15:848–862. 2013. View Article : Google Scholar : PubMed/NCBI
|
48
|
Quintanilla-Martinez L, Kremer M, Specht
K, Calzada-Wack J, Nathrath M, Schaich R, Höfler H and Fend F:
Analysis of signal transducer and activator of transcription 3
(Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin
D1 dysregulation are mutually exclusive events. Am J Pathol.
162:1449–1461. 2003. View Article : Google Scholar : PubMed/NCBI
|
49
|
Zhang Q, Raghunath PN, Vonderheid E, Odum
N and Wasik MA: Lack of phosphotyrosine phosphatase SHP-1
expression in malignant T-cell lymphoma cells results from
methylation of the SHP-1 promoter. Am J Pathol. 157:1137–1146.
2000. View Article : Google Scholar : PubMed/NCBI
|
50
|
Depil S, Saudemont A and Quesnel B: SOCS-1
gene methylation is frequent but does not appear to have prognostic
value in patients with multiple myeloma. Leukemia. 17:1678–1679.
2003. View Article : Google Scholar : PubMed/NCBI
|
51
|
Catlett-Falcone R, Landowski TH, Oshiro
MM, Turkson J, Levitzki A, Savino R, Ciliberto G, Moscinski L,
Fernández-Luna JL, Nuñez G, et al: Constitutive activation of Stat3
signaling confers resistance to apoptosis in human U266 myeloma
cells. Immunity. 10:105–115. 1999. View Article : Google Scholar : PubMed/NCBI
|
52
|
Heere-Ress E, Thallinger C, Lucas T,
Schlagbauer-Wadl H, Wacheck V, Monia BP, Wolff K, Pehamberger H and
Jansen B: Bcl-X(L) is a chemoresistance factor in human melanoma
cells that can be inhibited by antisense therapy. Int J Cancer.
99:29–34. 2002. View Article : Google Scholar : PubMed/NCBI
|
53
|
Digicaylioglu M and Lipton SA:
Erythropoietin-mediated neuro-protection involves cross-talk
between Jak2 and NF-kappaB signalling cascades. Nature.
412:641–647. 2001. View Article : Google Scholar : PubMed/NCBI
|