Open Access

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

  • Authors:
    • Wen Kang
    • Xiao Zheng
    • Ping Wang
    • Shanyu Guo
  • View Affiliations

  • Published online on: March 5, 2018     https://doi.org/10.3892/ijmm.2018.3532
  • Pages: 3157-3166
  • Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

During the pathogenesis of gastric cancer, Akt signaling is considered as a pivotal inducer of gastric cancer development. Here we report the identification of anticancer activities of deguelin, a natural agent that inhibits Akt signaling. When applied to MGC-803 and MKN-45 cells, deguelin suppressed the proliferation and arrested cell cycle by p21-mediated inhibition of cyclin E. We further present in vitro evidence that deguelin promoted apoptosis of cancer cells by decreasing the phospho-Akt signaling and affecting expression of the apoptosis-associated genes Bax and Bcl-2. Additionally, deguelin was found to suppress the migration and invasion of gastric cancer cells. Taken together, these results indicated that deguelin exerted anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.
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June-2018
Volume 41 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kang W, Zheng X, Wang P and Guo S: Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. Int J Mol Med 41: 3157-3166, 2018
APA
Kang, W., Zheng, X., Wang, P., & Guo, S. (2018). Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. International Journal of Molecular Medicine, 41, 3157-3166. https://doi.org/10.3892/ijmm.2018.3532
MLA
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41.6 (2018): 3157-3166.
Chicago
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41, no. 6 (2018): 3157-3166. https://doi.org/10.3892/ijmm.2018.3532