1
|
Brenner H, Rothenbacher D and Arndt V:
Epidemiology of stomach cancer. Methods Mol Biol. 472:467–477.
2009. View Article : Google Scholar
|
2
|
Orditura M, Galizia G, Sforza V,
Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J,
Savastano B, Mabilia A, et al: Treatment of gastric cancer. World J
Gastroenterol. 20:1635–1649. 2014. View Article : Google Scholar : PubMed/NCBI
|
3
|
Tian WY, Chen WC, Li R and Liu L: Markers
CD40, VEGF, AKT, PI3K and S100 correlate with tumor stage in
gastric cancer. Onkologie. 36:26–31. 2013.
|
4
|
Ye B, Jiang LL, Xu HT, Zhou DW and Li ZS:
Expression of PI3K/AKT pathway in gastric cancer and its blockade
suppresses tumor growth and metastasis. Int J Immunopathol
Pharmacol. 25:627–636. 2012. View Article : Google Scholar : PubMed/NCBI
|
5
|
Sukawa Y, Yamamoto H, Nosho K, Kunimoto H,
Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, et
al: Alterations in the human epidermal growth factor receptor
2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer.
World J Gastroenterol. 18:6577–6586. 2012. View Article : Google Scholar : PubMed/NCBI
|
6
|
Wu W, Hai Y, Chen L, Liu RJ, Han YX, Li
WH, Li S, Lin S and Wu XR: Deguelin-induced blockade of I3K/protein
kinase B/MAP kinase signaling in zebrafish and breast cancer cell
lines is mediated by downregulation of fibroblast growth factor
receptor 4 activity. Pharmacol Res Perspect. 4:e002122016.
View Article : Google Scholar
|
7
|
Chun KH, Kosmeder JW II, Sun S, Pezzuto
JM, Lotan R, Hong WK and Lee HY: Effects of deguelin on the
phosphatidylinositol 3-kinase/Akt pathway and apoptosis in
premalignant human bronchial epithelial cells. J Natl Cancer Inst.
95:291–302. 2003. View Article : Google Scholar : PubMed/NCBI
|
8
|
Thamilselvan V, Menon M and Thamilselvan
S: Anticancer efficacy of deguelin in human prostate cancer cells
targeting glycogen synthase kinase-3β/β-catenin pathway. Int J
Cancer. 129:2916–2927. 2011. View Article : Google Scholar : PubMed/NCBI
|
9
|
Yan B, Zhao D, Yao Y, Bao Z, Lu G and Zhou
J: Deguelin induces the apoptosis of lung squamous cell carcinoma
cells through regulating the expression of galectin-1. Int J Biol
Sci. 12:850–860. 2016. View Article : Google Scholar : PubMed/NCBI
|
10
|
Murillo G, Salti GI, Kosmeder JW II,
Pezzuto JM and Mehta RG: Deguelin inhibits the growth of colon
cancer cells through the induction of apoptosis and cell cycle
arrest. Eur J Cancer. 38:2446–2454. 2002. View Article : Google Scholar : PubMed/NCBI
|
11
|
Wang Y, Ma W and Zheng W: Deguelin, a
novel antitumorigenic agent targeting apoptosis, cell cycle arrest
and anti-angiogenesis for cancer chemoprevention. Mol Clin Oncol.
1:215–219. 2013. View Article : Google Scholar
|
12
|
Baba Y, Fujii M, Maeda T, Suzuki A, Yuzawa
S and Kato Y: Deguelin induces apoptosis by targeting both EGFR-Akt
and IGF1R-Akt pathways in head and neck squamous cell cancer cell
lines. BioMed Res Int. 2015:6571792015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Mehta RR, Katta H, Kalra A, Patel R, Gupta
A, Alimirah F, Murillo G, Peng X, Unni A, Muzzio M, et al: Efficacy
and mechanism of action of Deguelin in suppressing metastasis of
4T1 cells. Clin Exp Metastasis. 30:855–866. 2013. View Article : Google Scholar : PubMed/NCBI
|
14
|
Karimi P, Islami F, Anandasabapathy S,
Freedman ND and Kamangar F: Gastric cancer: Descriptive
epidemiology, risk factors, screening, and prevention. Cancer
Epidemiol Biomarkers Prev. 23:700–713. 2014. View Article : Google Scholar : PubMed/NCBI
|
15
|
Clarke JS, Cruze K, El Farra S and
Longmire WP Jr: The natural history and results of surgical therapy
for carcinoma of the stomach. An analysis of 250 cases. Am J Surg.
102:143–152. 1961. View Article : Google Scholar : PubMed/NCBI
|
16
|
Janunger KG, Hafström L, Nygren P and
Glimelius B; SBU-group: Swedish council of technology assessment in
health care: A systematic overview of chemotherapy effects in
gastric cancer. Acta Oncol. 40:309–326. 2001. View Article : Google Scholar
|
17
|
Zhao H, Jiao Y and Zhang Z: Deguelin
inhibits the migration and invasion of lung cancer A549 and H460
cells via regulating actin cytoskeleton rearrangement. Int J Clin
Exp Pathol. 8:15582–15590. 2015.
|
18
|
Yi S, Wen L, He J, Wang Y, Zhao F, Zhao J,
Zhao Z, Cui G and Chen Y: Deguelin, a selective silencer of the
NPM1 mutant, potentiates apoptosis and induces differentiation in
AML cells carrying the NPM1 mutation. Ann Hematol. 94:201–210.
2015. View Article : Google Scholar
|
19
|
Murillo G, Peng X, Torres KE and Mehta RG:
Deguelin inhibits growth of breast cancer cells by modulating the
expression of key members of the Wnt signaling pathway. Cancer Prev
Res (Phila). 2:942–950. 2009. View Article : Google Scholar
|
20
|
Xiong JR and Liu HL: Regulatory effects of
deguelin on proliferation and cell cycle of Raji cells. J Huazhong
Univ Sci Technolog Med Sci. 33:491–495. 2013. View Article : Google Scholar : PubMed/NCBI
|
21
|
Xiong Y, Hannon GJ, Zhang H, Casso D,
Kobayashi R and Beach D: p21 is a universal inhibitor of cyclin
kinases. Nature. 366:701–704. 1993. View Article : Google Scholar : PubMed/NCBI
|
22
|
Okuyama T, Maehara Y, Kabashima A,
Takahashi I, Kakeji Y and Sugimachi K: Combined evaluation of
expressions of p53 and p21 proteins as prognostic factors for
patients with gastric carcinoma. Oncology. 63:353–361. 2002.
View Article : Google Scholar : PubMed/NCBI
|
23
|
Radhakrishnan SK, Feliciano CS, Najmabadi
F, Haegebarth A, Kandel ES, Tyner AL and Gartel AL: Constitutive
expression of E2F-1 leads to p21-dependent cell cycle arrest in S
phase of the cell cycle. Oncogene. 23:4173–4176. 2004. View Article : Google Scholar : PubMed/NCBI
|
24
|
Mehta R, Katta H, Alimirah F, Patel R,
Murillo G, Peng X, Muzzio M and Mehta RG: Deguelin action involves
c-Met and EGFR signaling pathways in triple negative breast cancer
cells. PLoS One. 8:e651132013. View Article : Google Scholar : PubMed/NCBI
|
25
|
Hu J, Ye H, Fu A, Chen X, Wang Y, Chen X,
Ye X, Xiao W, Duan X, Wei Y, et al: Deguelin - an inhibitor to
tumor lymphangiogenesis and lymphatic metastasis by downregulation
of vascular endothelial cell growth factor-D in lung tumor model.
Int J Cancer. 127:2455–2466. 2010. View Article : Google Scholar : PubMed/NCBI
|
26
|
Peng XH, Karna P, O'Regan RM, Liu X,
Naithani R, Moriarty RM, Wood WC, Lee HY and Yang L: Downregulation
of inhibitor of apoptosis proteins by deguelin selectively induces
apoptosis in breast cancer cells. Mol Pharmacol. 71:101–111. 2007.
View Article : Google Scholar
|
27
|
Chen Y, Wu Q, Cui GH, Chen YQ and Li R:
Deguelin blocks cells survival signal pathways and induces
apoptosis of HL-60 cells in vitro. Int J Hematol. 89:618–623. 2009.
View Article : Google Scholar : PubMed/NCBI
|
28
|
Bortul R, Tazzari PL, Billi AM, Tabellini
G, Mantovani I, Cappellini A, Grafone T, Martinelli G, Conte R and
Martelli AM: Deguelin, A PI3K/AKT inhibitor, enhances
chemosensitivity of leukaemia cells with an active PI3K/AKT
pathway. Br J Haematol. 129:677–686. 2005. View Article : Google Scholar : PubMed/NCBI
|
29
|
Chu ZH, Liang XH, Zhou XL, Huang RF, Zhan
Q and Jiang JW: Effects of deguelin on proliferation and apoptosis
of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt
signaling pathway. Zhong Xi Yi Jie He Xue Bao. 9:533–538. 2011.In
Chinese. View Article : Google Scholar : PubMed/NCBI
|
30
|
Chiu TH, Lan KY, Yang MD, Lin JJ, Hsia TC,
Wu CT, Yang JS, Chueh FS and Chung JG: Diallyl sulfide promotes
cell-cycle arrest through the p53 expression and triggers induction
of apoptosis via caspase- and mitochondria-dependent signaling
pathways in human cervical cancer Ca Ski cells. Nutr Cancer.
65:505–514. 2013. View Article : Google Scholar : PubMed/NCBI
|
31
|
Wu J, Yang J, Liu Q, Wu S, Ma H and Cai Y:
Lanthanum induced primary neuronal apoptosis through mitochondrial
dysfunction modulated by Ca2+ and Bcl-2 family. Biol
Trace Elem Res. 152:125–134. 2013. View Article : Google Scholar : PubMed/NCBI
|
32
|
van Gurp M, Festjens N, van Loo G, Saelens
X and Vandenabeele P: Mitochondrial intermembrane proteins in cell
death. Biochem Biophys Res Commun. 304:487–497. 2003. View Article : Google Scholar : PubMed/NCBI
|
33
|
Scorrano L and Korsmeyer SJ: Mechanisms of
cytochrome c release by proapoptotic BCL-2 family members. Biochem
Biophys Res Commun. 304:437–444. 2003. View Article : Google Scholar : PubMed/NCBI
|
34
|
Kuwana T, Mackey MR, Perkins G, Ellisman
MH, Latterich M, Schneiter R, Green DR and Newmeyer DD: Bid, Bax,
and lipids cooperate to form supramolecular openings in the outer
mitochondrial membrane. Cell. 111:331–342. 2002. View Article : Google Scholar : PubMed/NCBI
|
35
|
Crompton M: Bax, Bid and the
permeabilization of the mitochondrial outer membrane in apoptosis.
Curr Opin Cell Biol. 12:414–419. 2000. View Article : Google Scholar : PubMed/NCBI
|
36
|
Wei MC, Zong WX, Cheng EH, Lindsten T,
Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB and
Korsmeyer SJ: Proapoptotic BAX and BAK: A requisite gateway to
mitochondrial dysfunction and death. Science. 292:727–730. 2001.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Kim R, Emi M and Tanabe K: Role of
mitochondria as the gardens of cell death. Cancer Chemother
Pharmacol. 57:545–553. 2006. View Article : Google Scholar
|
38
|
Green DR and Reed JC: Mitochondria and
apoptosis. Science. 281:1309–1312. 1998. View Article : Google Scholar : PubMed/NCBI
|
39
|
Gross A, McDonnell JM and Korsmeyer SJ:
BCL-2 family members and the mitochondria in apoptosis. Genes Dev.
13:1899–1911. 1999. View Article : Google Scholar : PubMed/NCBI
|
40
|
Ghribi O, Herman MM, Spaulding NK and
Savory J: Lithium inhibits aluminum-induced apoptosis in rabbit
hippocampus, by preventing cytochrome c translocation, Bcl-2
decrease, Bax elevation and caspase-3 activation. J Neurochem.
82:137–145. 2002. View Article : Google Scholar : PubMed/NCBI
|
41
|
Rossé T, Olivier R, Monney L, Rager M,
Conus S, Fellay I, Jansen B and Borner C: Bcl-2 prolongs cell
survival after Bax-induced release of cytochrome c. Nature.
391:496–499. 1998. View
Article : Google Scholar : PubMed/NCBI
|
42
|
Liu YP, Lee JJ, Lai TC, Lee CH, Hsiao YW,
Chen PS, Liu WT, Hong CY, Lin SK, Ping Kuo MY, et al: Suppressive
function of low-dose deguelin on the invasion of oral cancer cells
by downregulating tumor necrosis factor alpha-induced nuclear
factor-kappa B signaling. Head Neck. 38(Suppl 1): E524–E534. 2016.
View Article : Google Scholar
|
43
|
Boreddy SR and Srivastava SK: Deguelin
suppresses pancreatic tumor growth and metastasis by inhibiting
epithelial-to-mesenchymal transition in an orthotopic model.
Oncogene. 32:3980–3991. 2013. View Article : Google Scholar
|
44
|
Shang HS, Chang JB, Lin JH, Lin JP, Hsu
SC, Liu CM, Liu JY, Wu PP, Lu HF, Au MK, et al: Deguelin inhibits
the migration and invasion of U-2 OS human osteosarcoma cells via
the inhibition of matrix metalloproteinase-2/-9 in vitro.
Molecules. 19:16588–16608. 2014. View Article : Google Scholar : PubMed/NCBI
|
45
|
Yang YL, Ji C, Bi ZG, Lu CC, Wang R, Gu B
and Cheng L: Deguelin induces both apoptosis and autophagy in
cultured head and neck squamous cell carcinoma cells. PLoS One.
8:e547362013. View Article : Google Scholar : PubMed/NCBI
|