Circular RNA, a novel marker for cancer determination (Review)

  • Authors:
    • Yinjie Su
    • Guangzheng Zhong
    • Ning Jiang
    • Ming Huang
    • Tianxin Lin
  • View Affiliations

  • Published online on: July 30, 2018     https://doi.org/10.3892/ijmm.2018.3795
  • Pages: 1786-1798
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Abstract

Circular RNAs are abundant and conserved endogenous RNAs that are formed by exon skipping or back‑splicing events and occur in all forms of life. They have been proven to exhibit tissue‑ or cell‑type specificity and to be able to regulate cell behavior through multiple pathways. In cancer research, numerous studies have indicated that circular RNAs serve as potential biomarkers and therapeutic targets. Furthermore, differential expression of certain circular RNAs clearly predicts the clinical outcomes of cancer patients. Circular RNAs regulate carcinogenesis and cancer progression by acting as a microRNA sponge, coding for proteins and interacting with proteins. The present review mainly focuses on the recent literature regarding the role of circular RNAs in cancer, which may suggest novel strategies for cancer prognosis, diagnosis and clinical treatment.
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October-2018
Volume 42 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Su Y, Zhong G, Jiang N, Huang M and Lin T: Circular RNA, a novel marker for cancer determination (Review). Int J Mol Med 42: 1786-1798, 2018.
APA
Su, Y., Zhong, G., Jiang, N., Huang, M., & Lin, T. (2018). Circular RNA, a novel marker for cancer determination (Review). International Journal of Molecular Medicine, 42, 1786-1798. https://doi.org/10.3892/ijmm.2018.3795
MLA
Su, Y., Zhong, G., Jiang, N., Huang, M., Lin, T."Circular RNA, a novel marker for cancer determination (Review)". International Journal of Molecular Medicine 42.4 (2018): 1786-1798.
Chicago
Su, Y., Zhong, G., Jiang, N., Huang, M., Lin, T."Circular RNA, a novel marker for cancer determination (Review)". International Journal of Molecular Medicine 42, no. 4 (2018): 1786-1798. https://doi.org/10.3892/ijmm.2018.3795