MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Li,Chao; Wang,Zi; Chen,Shuangjiang; Zhang,Jingyao; Qu,Kai; Liu,Chang

doi:10.3892/ijmm.2018.3882

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Authors:
- Chao Li
- Zi Wang
- Shuangjiang Chen
- Jingyao Zhang
- Kai Qu
- Chang Liu
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Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of General Surgery, Ankang People's Hospital, Ankang, Shaanxi 725000, P.R. China
Published online on: September 17, 2018 https://doi.org/10.3892/ijmm.2018.3882
Pages: 3309-3317
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs/miRs) are involved in the metastasis of hepatocellular carcinoma (HCC). In the present study, it was demonstrated that miR‑552 was upregulated in HCC tissues. High miR‑552 expression was associated with malignant clinicopathological features and decreased survival rates. The in vitro results indicated that miR‑552 overexpression promoted migration, invasion and epithelial‑mesenchymal transition in Hep3B cells. However, the knockdown of miR‑552 inhibited its oncogenic roles in Huh‑7 cells. Additionally, Wnt inhibitory factor 1 (WIF1) was demonstrated to be a direct target of miR‑552 in Hep3B and Huh‑7 cells. Additional experiments identified that miR‑552 promotes β‑catenin expression by increasing the phosphorylation of GSK3β at Ser9. In conclusion, the results suggested that miR‑552 may promote HCC progression by blocking WIF1‑mediated GSK3β dephosphorylation. miR‑552 may be a biomarker for predicting the outcomes of patients with HCC.

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