Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Ma,Chongyang; Liu,Shuling; Zhang,Shuang; Xu,Tian; Yu,Xue; Gao,Yushan; Zhai,Changming; Li,Changxiang; Lei,Chaofang; Fan,Shuning; Chen,Yuxi; Tian,Huiling; Wang,Qingguo; Cheng,Fafeng; Wang,Xueqian

doi:10.3892/ijmm.2018.3911

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Authors:
- Chongyang Ma
- Shuling Liu
- Shuang Zhang
- Tian Xu
- Xue Yu
- Yushan Gao
- Changming Zhai
- Changxiang Li
- Chaofang Lei
- Shuning Fan
- Yuxi Chen
- Huiling Tian
- Qingguo Wang
- Fafeng Cheng
- Xueqian Wang
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Affiliations: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, P.R. China
Published online on: October 2, 2018 https://doi.org/10.3892/ijmm.2018.3911
Pages: 2979-2990

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Abstract

Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke.

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