Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)

Wang,Hongwei; Li,Mingzhe; Zhang,Zhenzhen; Xue,Haifeng; Chen,Xing; Ji,Yong

doi:10.3892/ijmm.2018.3992

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review)

Authors:
- Hongwei Wang
- Mingzhe Li
- Zhenzhen Zhang
- Haifeng Xue
- Xing Chen
- Yong Ji
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Affiliations: Department of Ophthalmology, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China, Department of Ophthalmology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China, Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China, Public Health School, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China, Department of Science and Education, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China, Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China
Published online on: November 20, 2018 https://doi.org/10.3892/ijmm.2018.3992
Pages: 671-681
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP. High IOP is a well‑known primary risk factor for glaucoma. Myocilin mutations are common among glaucoma patients, and they are implicated in juvenile‑onset open‑angle glaucoma (JOAG) and adult‑onset primary open‑angle glaucoma (POAG). Aggregation of aberrant mutant myocilins is closely associated with glaucoma pathogenesis. The aim of the present review was to discuss the recent findings regarding the major physiological functions of myocilin, such as intra‑ and extracellular proteolytic processes. We also aimed to discuss the risk factors associated with myocilin and the development of glaucoma, such as misfolded/mutant myocilin, imbalance of myocilin and extracellular proteins, and instability of mutant myocilin associated with temperature. Finally, we further outlined certain issues that are yet to be resolved, which may represent the basis for future studies on the role of myocilin in glaucoma.

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