Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Lee,Jae‑Won; Ryu,Hyung   Won; Lee,Su   Ui; Kim,Min‑Gu; Kwon,Ok‑Kyoung; Kim,Mun   Ok; Oh,Tae  Kyu; Lee,Jae   Kyoung; Kim,Tae   Young; Lee,Sang   Woo; Choi,Sangho; Li,Wan‑Yi; Ahn,Kyung‑Seop; Oh,Sei‑Ryang

doi:10.3892/ijmm.2019.4247

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Authors:
- Jae‑Won Lee
- Hyung Won Ryu
- Su Ui Lee
- Min‑Gu Kim
- Ok‑Kyoung Kwon
- Mun Ok Kim
- Tae Kyu Oh
- Jae Kyoung Lee
- Tae Young Kim
- Sang Woo Lee
- Sangho Choi
- Wan‑Yi Li
- Kyung‑Seop Ahn
- Sei‑Ryang Oh
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Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungcheongbuk‑do 28116, Republic of Korea, BTC Corporation, Technology Development Center, Ansan, Gyeonggi‑do 15588, Republic of Korea, International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea, Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming, Yunnan 650200, P.R. China
Published online on: June 20, 2019 https://doi.org/10.3892/ijmm.2019.4247
Pages: 949-959
Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW has not been known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present in vitro analysis confirmed that PW root extract (PWRE) exerts anti‑inflammatory effects in phorbol myristate acetate‑ or tumor necrosis factor α (TNF‑α)‑stimulated human lung epithelial NCI‑H292 cells by attenuating the expression of interleukin (IL)‑8, IL‑6 and Mucin A5 (MUC5AC), which are closely associated with the pulmonary inflammatory response in the pathogenesis of COPD. Thus, the aim of the present study was to evaluate the protective effect of PWRE on pulmonary inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). Treatment with PWRE significantly reduced the quantity of neutrophils and the levels of inflammatory molecules and toxic molecules, including tumor TNF‑α, IL‑6, IL‑8, monocyte chemoattractant protein‑1, neutrophil elastase and reactive oxygen species, in the bronchoalveolar lavage fluid of mice with CS‑ and LPS‑induced pulmonary inflammation. PWRE also attenuated the influx of inflammatory cells in the lung tissues. Furthermore, PWRE downregulated the activation of nuclear factor‑κB and the expression of phosphodiesterase 4 in the lung tissues. Therefore, these findings suggest that PWRE may be a valuable adjuvant treatment for COPD.

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