Open Access

miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation

  • Authors:
    • Hu‑Nian Li
    • Xu Zhao
    • Yong‑Jiu Zha
    • Fang Du
    • Jie Liu
    • Liang Sun
  • View Affiliations

  • Published online on: October 22, 2019     https://doi.org/10.3892/ijmm.2019.4380
  • Pages: 2003-2014
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, we examined the function of microRNA (miR)‑146a‑5p in patients with refractory Mycoplasma pneumoniae pneumonia. In brief, the expression of miR‑146a‑5p was reduced in patients with refractory Mycoplasma pneumoniae pneumonia. Downregulation of miR‑146a‑5p reduced inflammation in an in vitro model of refractory Mycoplasma pneumoniae pneumonia, whilst overexpression of miR‑146a‑5p promoted inflammation. Downregulation of miR‑146a‑5p induced the protein expression of ATP‑binding cassette subfamily G member 1 (ABCG1) and interleukin 1 receptor‑associated kinase 1 (IRAK‑1), while suppressed expression was observed of the aforementioned proteins following overexpression of miR‑146a‑5p in an in vitro model of refractory Mycoplasma pneumoniae pneumonia. The administration of small interfering RNA against RXR or IRAK‑1 attenuated the effects of miR‑146a‑5p on inflammation in an in vitro model of refractory Mycoplasma pneumoniae pneumonia. Collectively, these results suggested that miR‑146a‑5p reduced ABCG1 expression in refractory Mycoplasma pneumoniae pneumonia via downregulation of IRAK‑1.
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December-2019
Volume 44 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Li HN, Zhao X, Zha YJ, Du F, Liu J and Sun L: miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. Int J Mol Med 44: 2003-2014, 2019.
APA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., & Sun, L. (2019). miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation. International Journal of Molecular Medicine, 44, 2003-2014. https://doi.org/10.3892/ijmm.2019.4380
MLA
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44.6 (2019): 2003-2014.
Chicago
Li, H., Zhao, X., Zha, Y., Du, F., Liu, J., Sun, L."miR‑146a‑5p suppresses ATP‑binding cassette subfamily G member 1 dysregulation in patients with refractory Mycoplasma pneumoniae via interleukin 1 receptor‑associated kinase 1 downregulation". International Journal of Molecular Medicine 44, no. 6 (2019): 2003-2014. https://doi.org/10.3892/ijmm.2019.4380