Open Access

Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis

Retraction in: /10.3892/ijmm.2022.5080

  • Authors:
    • Jianwei Xiao
    • Rongsheng Wang
    • Weijian Zhou
    • Xu Cai
    • Zhizhong Ye
  • View Affiliations

  • Published online on: October 27, 2020     https://doi.org/10.3892/ijmm.2020.4772
  • Pages: 232-242
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a chronic disease that results in chronic arthralgia and functional disability of the affected joint. To date, there is no effective treatment available for this disease. Circular RNAs (circRNAs) are a type of intracellular stable RNA that can regulate the development and progression of OA. However, the function of circCSNK1G1 in OA has not yet been investigated. In the present study, it was found that circCSNK1G1 was upregulated in OA cartilage tissues. The upregulation of circCSNK1G1 was associated with extracellular matrix (ECM) degradation and chondrocyte apoptosis. Moreover, the expression of miR‑4428 was downregulated and that of fucosyltransferase 2 (FUT2) was upregulated in OA‑affected cartilage tissues. Dual‑luciferase reporter assay and RNA immunoprecipitation confirmed that miR‑4428 targeted FUT2 mRNA to inhibit FUT2 expression. circCSNK1G1 and FUT2 induced ECM degradation and chondrocyte apoptosis. The negative effects of circCSNK1G1 and FUT2 were reversed by miR‑4428. On the whole, the present study demonstrates that circCSNK1G1 promotes the development of OA by targeting the miR‑4428/FUT2 axis. Thus, the circCSNK1G1/miR‑4428/FUT2 axis may present a novel target for the treatment of OA in the clinical setting.
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January-2021
Volume 47 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Xiao J, Wang R, Zhou W, Cai X and Ye Z: Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis Retraction in /10.3892/ijmm.2022.5080. Int J Mol Med 47: 232-242, 2021.
APA
Xiao, J., Wang, R., Zhou, W., Cai, X., & Ye, Z. (2021). Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis Retraction in /10.3892/ijmm.2022.5080. International Journal of Molecular Medicine, 47, 232-242. https://doi.org/10.3892/ijmm.2020.4772
MLA
Xiao, J., Wang, R., Zhou, W., Cai, X., Ye, Z."Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis Retraction in /10.3892/ijmm.2022.5080". International Journal of Molecular Medicine 47.1 (2021): 232-242.
Chicago
Xiao, J., Wang, R., Zhou, W., Cai, X., Ye, Z."Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis Retraction in /10.3892/ijmm.2022.5080". International Journal of Molecular Medicine 47, no. 1 (2021): 232-242. https://doi.org/10.3892/ijmm.2020.4772