Open Access

Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)

  • Authors:
    • Wenjing Gong
    • Tracey A. Martin
    • Andrew J. Sanders
    • Aihua Jiang
    • Ping Sun
    • Wen G. Jiang
  • View Affiliations

  • Published online on: December 4, 2020     https://doi.org/10.3892/ijmm.2020.4811
  • Pages: 435-443
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite improvements in therapy and management, cancer represents and remains a major cause of mortality and morbidity worldwide. Although genetics serve an important role in tumorigenesis and tumour progression, the tumour microenvironment (TME) in solid tumours is also important and has been indicated to contribute to these processes. Stromal cell‑derived factors (SDFs) represent an important family within the TME. The family includes SDF‑1, SDF‑2, SDF2‑like 1 (SDF2L1), SDF‑3, SDF‑4 and SDF‑5. SDF‑1 has been demonstrated to act as a positive regulator in a number of types of tumour, such as oesophago‑gastric, pancreatic, lung, breast, colorectal and ovarian cancer, while the biology and functions of other members of the SDF family, including SDF‑2, SDF2L1, SDF‑4 and SDF‑5, in cancer are different, complex and controversial, and remain mainly unknown. Full identification and understanding of the SDFs across multiple types of cancer is required to elucidate their function and establish potential key targets in cancer.
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February-2021
Volume 47 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Gong W, Martin TA, Sanders AJ, Jiang A, Sun P and Jiang WG: Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). Int J Mol Med 47: 435-443, 2021.
APA
Gong, W., Martin, T.A., Sanders, A.J., Jiang, A., Sun, P., & Jiang, W.G. (2021). Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review). International Journal of Molecular Medicine, 47, 435-443. https://doi.org/10.3892/ijmm.2020.4811
MLA
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47.2 (2021): 435-443.
Chicago
Gong, W., Martin, T. A., Sanders, A. J., Jiang, A., Sun, P., Jiang, W. G."Location, function and role of stromal cell‑derived factors and possible implications in cancer (Review)". International Journal of Molecular Medicine 47, no. 2 (2021): 435-443. https://doi.org/10.3892/ijmm.2020.4811