Open Access

The potential role of necroptosis in clinical diseases (Review)

  • Authors:
    • Wenli Dai
    • Jin Cheng
    • Xi Leng
    • Xiaoqing Hu
    • Yingfang Ao
  • View Affiliations

  • Published online on: March 26, 2021     https://doi.org/10.3892/ijmm.2021.4922
  • Article Number: 89
  • Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As an important type of programmed cell death in addition to apoptosis, necroptosis occurs in a variety of pathophysiological processes, including infections, liver diseases, kidney injury, neurodegenerative diseases, cardiovascular diseases, and human tumors. It can be triggered by a variety of factors, such as tumor necrosis factor receptor and Toll‑like receptor families, intracellular DNA and RNA sensors, and interferon, and is mainly mediated by receptor‑interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain‑like protein. A better understanding of the mechanism of necroptosis may be useful in the development of novel drugs for necroptosis‑related diseases. In this review, the focus is on the molecular mechanisms of necroptosis, exploring the role of necroptosis in different pathologies, discussing their potential as a novel therapeutic target for disease therapy, and providing suggestions for further study in this area.
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May-2021
Volume 47 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Dai W, Cheng J, Leng X, Hu X and Ao Y: The potential role of necroptosis in clinical diseases (Review). Int J Mol Med 47: 89, 2021.
APA
Dai, W., Cheng, J., Leng, X., Hu, X., & Ao, Y. (2021). The potential role of necroptosis in clinical diseases (Review). International Journal of Molecular Medicine, 47, 89. https://doi.org/10.3892/ijmm.2021.4922
MLA
Dai, W., Cheng, J., Leng, X., Hu, X., Ao, Y."The potential role of necroptosis in clinical diseases (Review)". International Journal of Molecular Medicine 47.5 (2021): 89.
Chicago
Dai, W., Cheng, J., Leng, X., Hu, X., Ao, Y."The potential role of necroptosis in clinical diseases (Review)". International Journal of Molecular Medicine 47, no. 5 (2021): 89. https://doi.org/10.3892/ijmm.2021.4922