An update on genetic basis of generalized pustular psoriasis (Review)
- Authors:
- Jiahong Zhou
- Qing Luo
- Yang Cheng
- Xia Wen
- Jinbo Liu
-
Affiliations: Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China - Published online on: April 28, 2021 https://doi.org/10.3892/ijmm.2021.4951
- Article Number: 118
-
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, Kingo K, Smith C and Barker JN; ERASPEN Network: European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol. 31:1792–1799. 2017. View Article : Google Scholar : PubMed/NCBI | |
Baker H and Ryan TJ: Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases. Br J Dermatol. 80:771–793. 1968. View Article : Google Scholar : PubMed/NCBI | |
Ohkawara A, Yasuda H, Kobayashi H, Inaba Y, Ogawa H, Hashimoto I and Imamura S: Generalized pustular psoriasis in Japan: Two distinct groups formed by differences in symptoms and genetic background. Acta Derm Venereol. 76:68–71. 1996.PubMed/NCBI | |
Augey F, Renaudier P and Nicolas JF: Generalized pustular psoriasis (Zumbusch): A French epidemiological survey. Eur J Dermatol. 16:669–673. 2006. | |
Ito T, Takahashi H, Kawada A, Iizuka H, Nakagawa H, Japanese Society For and Psoriasis Research: Epidemiological survey from 2009 to 2012 of psoriatic patients in Japanese society for psoriasis research. J Dermatol. 45:293–301. 2018. View Article : Google Scholar | |
Takahashi H, Nakamura K, Kaneko F and Nakagawa H: Analysis of psoriasis patients registered with the Japanese society for psoriasis research from 2002-2008. J Dermatol. 38:1125–1129. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chen L, Huang X, Xiao Y, Su J, Shen M and Chen X: Prevalence and risk factors of atopic dermatitis, psoriasis, acne, and urticaria in China. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 45:449–455. 2020.In English, Chinese. PubMed/NCBI | |
Talaee R, Hajheydari Z, Moghaddam AY, Moraveji SA and Ravandi BF: Prevalence of oral mucosal lesions and their association with severity of psoriasis among psoriatic patients referred to dermatology clinic: A cross-sectional study in Kashan/Iran. Open Access Maced J Med Sci. 5:978–982. 2017. View Article : Google Scholar | |
Griffiths CE and Barker JN: Pathogenesis and clinical features of psoriasis. Lancet. 370:263–271. 2007. View Article : Google Scholar : PubMed/NCBI | |
Steffen C: William John Munro and Munro's abscess, and Franz Kogoj and Kogoj's spongiform pustule. Am J Dermatopathol. 24:364–368. 2002. View Article : Google Scholar : PubMed/NCBI | |
Crowley JJ, Pariser DM and Yamauchi PS: A brief guide to pustular psoriasis for primary care providers. Postgrad Med. 1–15. 2020.Online Ahead of Print. | |
Benjegerdes KE, Hyde K, Kivelevitch D and Mansouri B: Pustular psoriasis: Pathophysiology and current treatment perspectives. Psoriasis (Auckl). 6:131–144. 2016. | |
Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, Tsuda K, Nishida E, Togawa Y, Nakajima K, et al: The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. J Invest Dermatol. 133:2514–2521. 2013. View Article : Google Scholar : PubMed/NCBI | |
Boehner A, Navarini AA and Eyerich K: Generalized pustular psoriasis-a model disease for specific targeted immunotherapy, systematic review. Exp Dermatol. 27:1067–1077. 2018. View Article : Google Scholar : PubMed/NCBI | |
Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, Jiao Q, Zhang C, Zhu C, Zhuang Y, et al: Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris. J Invest Dermatol. 133:2637–2639. 2013. View Article : Google Scholar : PubMed/NCBI | |
Li X, Chen M, Fu X, Zhang Q, Wang Z, Yu G, Yu Y, Qin P, Wu W, Pan F, et al: Mutation analysis of the IL36RN gene in Chinese patients with generalized pustular psoriasis with/without psoriasis vulgaris. J Dermatol Sci. 76:132–138. 2014. View Article : Google Scholar : PubMed/NCBI | |
Hussain S, Berki DM, Choon SE, Burden AD, Allen MH, Arostegui JI, Chaves A, Duckworth M, Irvine AD, Mockenhaupt M, et al: IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis. J Allergy Clin Immunol. 135:1067–1070.e9. 2015. View Article : Google Scholar | |
Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, Zribi J, Bal E, Cluzeau C, Chrabieh M, et al: Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 365:620–628. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jordan CT, Cao L, Roberson ED, Pierson KC, Yang CF, Joyce CE, Ryan C, Duan S, Helms CA, Liu Y, et al: PSORS2 is due to mutations in CARD14. Am J Hum Genet. 90:784–795. 2012. View Article : Google Scholar : PubMed/NCBI | |
Setta-Kaffetzi N, Simpson MA, Navarini AA, Patel VM, Lu HC, Allen MH, Duckworth M, Bachelez H, Burden AD, Choon SE, et al: AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 trafficking. Am J Hum Genet. 94:790–797. 2014. View Article : Google Scholar : PubMed/NCBI | |
Vergnano M, Mockenhaupt M, Benzian-Olsson N, Paulmann M, Grys K, Mahil SK, Chaloner C, Barbosa IA, August S, Burden AD, et al: Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease. Am J Hum Genet. 107:539–543. 2020. View Article : Google Scholar : PubMed/NCBI | |
Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, Cooper HL, Irvine AD, Oon HH, Kingo K, et al: Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol. 143:1021–1026. 2019. View Article : Google Scholar : | |
Mössner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Löhr S, Schulz P, Körber A, Prinz JC, Renner R, Schäkel K, et al: The genetic basis for most patients with pustular skin disease remains elusive. Br J Dermatol. 178:740–748. 2018. View Article : Google Scholar | |
Sugiura K, Muto M and Akiyama M: CARD14 c.526G>C (p.Asp176His) is a significant risk factor for generalized pustular psoriasis with psoriasis vulgaris in the Japanese cohort. J Invest Dermatol. 134:1755–1757. 2014. View Article : Google Scholar : PubMed/NCBI | |
Li L, You J, Fu X, Wang Z, Sun Y, Liu H and Zhang F: Variants of CARD14 are predisposing factors for generalized pustular psoriasis (GPP) with psoriasis vulgaris but not for GPP alone in a Chinese population. Br J Dermatol. 180:425–426. 2019. View Article : Google Scholar | |
Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Képíró L, Mockenhaupt M, Oon HH, et al: AP1S3 mutations cause skisn autoinflammation by disrupting keratinocyte autophagy and up-regulating IL-36 production. J Invest Dermatol. 136:2251–2259. 2016. View Article : Google Scholar : PubMed/NCBI | |
Towne JE, Garka KE, Renshaw BR, Virca GD and Sims JE: Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J Biol Chem. 279:13677–13688. 2004. View Article : Google Scholar : PubMed/NCBI | |
Buhl AL and Wenzel J: Interleukin-36 in infectious and inflammatory skin diseases. Front Immunol. 10:11622019. View Article : Google Scholar : PubMed/NCBI | |
Johnston A, Xing X, Wolterink L, Barnes DH, Yin Z, Reingold L, Kahlenberg JM, Harms PW and Gudjonsson JE: IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. J Allergy Clin Immunol. 140:109–120. 2017. View Article : Google Scholar : PubMed/NCBI | |
Onoufriadis A, Simpson MA, Pink AE, Di Meglio P, Smith CH, Pullabhatla V, Knight J, Spain SL, Nestle FO, Burden AD, et al: Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. Am J Hum Genet. 89:432–437. 2011. View Article : Google Scholar : PubMed/NCBI | |
Furue K, Yamamura K, Tsuji G, Mitoma C, Uchi H, Nakahara T, Kido-Nakahara M, Kadono T and Furue M: Highlighting interleukin-36 signalling in plaque psoriasis and pustular psoriasis. Acta Derm Venereol. 98:5–13. 2018. View Article : Google Scholar | |
Cowen EW and Goldbach-Mansky R: DIRA, DITRA, and new insights into pathways of skin inflammation: What's in a name? Arch Dermatol. 148:381–384. 2012. View Article : Google Scholar : PubMed/NCBI | |
Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, et al: An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 360:2426–2437. 2009. View Article : Google Scholar : PubMed/NCBI | |
Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ and Verbsky J: An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med. 360:2438–2444. 2009. View Article : Google Scholar : PubMed/NCBI | |
Sugiura K, Takeichi T, Kono M, Ogawa Y, Shimoyama Y, Muro Y and Akiyama M: A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis. Br J Dermatol. 167:699–701. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kanazawa N, Nakamura T, Mikita N and Furukawa F: Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis. J Dermatol. 40:749–751. 2013. View Article : Google Scholar : PubMed/NCBI | |
Farooq M, Nakai H, Fujimoto A, Fujikawa H, Matsuyama A, Kariya N, Aizawa A, Fujiwara H, Ito M and Shimomura Y: Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis. Hum Mutat. 34:176–183. 2013. View Article : Google Scholar | |
Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, Zenati A, Makrelouf M, Boubridaa K, Chiali A, et al: IL36RN mutations affect protein expression and function: A basis for genotype-phenotype correlation in pustular diseases. J Invest Dermatol. 136:1811–1819. 2016. View Article : Google Scholar : PubMed/NCBI | |
Setta-Kaffetzi N, Navarini AA, Patel VM, Pullabhatla V, Pink AE, Choon SE, Allen MA, Burden AD, Griffiths CE, Seyger MM, et al: Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. J Invest Dermatol. 133:1366–1369. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sugiura K, Nakasuka A, Kono H, Kono M and Akiyama M: Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. J Dermatol Sci. 79:319–320. 2015. View Article : Google Scholar : PubMed/NCBI | |
Shiratori T, Fukai K, Yasumizu M, Taguchi R, Tsuruta D, Abe Y, Hozumi Y and Suzuki T: IL36RN gene analysis of two Japanese patients with generalized pustular psoriasis. Int J Dermatol. 54:e60–e62. 2015. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Cheng R, Lu Z, Guo Y, Yan M, Liang J, Huang P, Li M and Yao Z: Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes. J Dermatol Sci. 85:235–240. 2017. View Article : Google Scholar : PubMed/NCBI | |
Renert-Yuval Y, Horev L, Babay S, Tams S, Ramot Y, Zlotogorski A and Molho-Pessach V: IL36RN mutation causing generalized pustular psoriasis in a Palestinian patient. Int J Dermatol. 53:866–868. 2014. View Article : Google Scholar : PubMed/NCBI | |
Ueda Y, Komine M, Kamiya K, Tsuda H, Maekawa T, Murata S and Ohtsuki M: Generalized pustular psoriasis in a 92-year-old man with a homozygous nonsense mutation in IL36RN. J Dermatol. 45:326–328. 2018. View Article : Google Scholar | |
Ellingford JM, Black GC, Clayton TH, Judge M, Griffiths CE and Warren RB: A novel mutation in IL36RN underpins childhood pustular dermatosis. J Eur Acad Dermatol Venereol. 30:302–305. 2016. View Article : Google Scholar : | |
Rossi-Semerano L, Piram M, Chiaverini C, De Ricaud D, Smahi A and Koné-Paut I: First clinical description of an infant with interleukin-36-receptor antagonist deficiency successfully treated with anakinra. Pediatrics. 132:e1043–e1047. 2013. View Article : Google Scholar : PubMed/NCBI | |
Körber A, Mössner R, Renner R, Sticht H, Wilsmann-Theis D, Schulz P, Sticherling M, Traupe H and Hüffmeier U: Mutations in IL36RN in patients with generalized pustular psoriasis. J Invest Dermatol. 133:2634–2637. 2013. View Article : Google Scholar : PubMed/NCBI | |
Takeichi T, Togawa Y, Okuno Y, Taniguchi R, Kono M, Matsue H, Sugiura K and Akiyama M: A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. J Dermatol Sci. 85:58–60. 2017. View Article : Google Scholar | |
Wang TS, Chiu HY, Hong JB, Chan CC, Lin SJ and Tsai TF: Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients. Arch Dermatol Res. 308:55–63. 2016. View Article : Google Scholar | |
Abbas O, Itani S, Ghosn S, Kibbi AG, Fidawi G, Farooq M, Shimomura Y and Kurban M: Acrodermatitis continua of Hallopeau is a clinical phenotype of DITRA: Evidence that it is a variant of pustular psoriasis. Dermatology. 226:28–31. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sugiura K, Endo K, Akasaka T and Akiyama M: Successful treatment with infliximab of sibling cases with generalized pustular psoriasis caused by deficiency of interleukin-36 receptor antagonist. J Eur Acad Dermatol Venereol. 29:2054–2056. 2015. View Article : Google Scholar | |
Song HS, Yun SJ, Park S and Lee ES: Gene mutation analysis in a Korean patient with early-onset and recalcitrant generalized pustular psoriasis. Ann Dermatol. 26:424–425. 2014. View Article : Google Scholar : PubMed/NCBI | |
Liang J, Zhang H, Guo Y, Yang K, Ni C, Yu H, Kong X, Li M, Lu Z and Yao Z: Coinheritance of generalized pustular psoriasis and familial Behçet-like autoinflammatory syndrome with variants in IL36RN and TNFAIP3 in the heterozygous state. J Dermatol. 46:907–910. 2019. View Article : Google Scholar : PubMed/NCBI | |
Scudiero I, Zotti T, Ferravante A, Vessichelli M, Vito P and Stilo R: Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-κB activation and endoplasmic reticulum stress-induced cell death. J Cell Physiol. 226:3121–3131. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS and Alnemri ES: CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem. 276:11877–11882. 2001. View Article : Google Scholar : PubMed/NCBI | |
Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, et al: Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 90:796–808. 2012. View Article : Google Scholar : PubMed/NCBI | |
Qin P, Zhang Q, Chen M, Fu X, Wang C, Wang Z, Yu G, Yu Y, Li X, Sun Y, et al: Variant analysis of CARD14 in a Chinese Han population with psoriasis vulgaris and generalized pustular psoriasis. J Invest Dermatol. 134:2994–2996. 2014. View Article : Google Scholar : PubMed/NCBI | |
Berki DM, Liu L, Choon SE, David Burden A, Griffiths CEM, Navarini AA, Tan ES, Irvine AD, Ranki A, Ogo T, et al: Activating CARD14 mutations are associated with generalized pustular psoriasis but rarely account for familial recurrence in psoriasis vulgaris. J Invest Dermatol. 135:2964–2970. 2015. View Article : Google Scholar : PubMed/NCBI | |
Haskamp S, Bruns H, Hahn M, Hoffmann M, Gregor A, Löhr S, Hahn J, Schauer C, Ringer M, Flamann C, et al: Myeloperoxidase modulates inflammation in generalized pustular psoriasis and additional rare pustular skin diseases. Am J Hum Genet. 107:527–538. 2020. View Article : Google Scholar : PubMed/NCBI | |
De Argila D, Dominguez JD, Lopez-Estebaranz JL and Iglesias L: Pustular psoriasis in a patient with myeloperoxidase deficiency. Dermatology. 193:2701996. View Article : Google Scholar : PubMed/NCBI | |
Stendahl O, Coble BI, Dahlgren C, Hed J and Molin L: Myeloperoxidase modulates the phagocytic activity of polymorphonuclear neutrophil leukocytes. Studies with cells from a myeloperoxidase-deficient patient. J Clin Invest. 73:366–373. 1984. View Article : Google Scholar : PubMed/NCBI | |
Kizaki M, Miller CW, Selsted ME and Koeffler HP: Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency. Blood. 83:1935–1940. 1994. View Article : Google Scholar : PubMed/NCBI | |
Marchetti C, Patriarca P, Solero GP, Baralle FE and Romano M: Genetic studies on myeloperoxidase deficiency in Italy. Jpn J Infect Dis. 57:S10–S12. 2004.PubMed/NCBI | |
Marchetti C, Patriarca P, Solero GP, Baralle FE and Romano M: Genetic characterization of myeloperoxidase deficiency in Italy. Hum Mutat. 23:496–505. 2004. View Article : Google Scholar : PubMed/NCBI | |
Akiyama M, Takeichi T, McGrath JA and Sugiura K: Autoinflammatory keratinization diseases. J Allergy Clin Immunol. 140:1545–1547. 2017. View Article : Google Scholar : PubMed/NCBI | |
Akiyama M: Early-onset generalized pustular psoriasis is representative of autoinflammatory keratinization diseases. J Allergy Clin Immunol. 143:809–810. 2019. View Article : Google Scholar : PubMed/NCBI | |
Kanazawa N: Designation of autoinflammatory skin manifestations with specific genetic backgrounds. Front Immunol. 11:4752020. View Article : Google Scholar : PubMed/NCBI | |
Takeichi T and Akiyama M: Familial or sporadic porokeratosis as an autoinflammatory keratinization disease. J Dermatol. 46. pp. e125–e126. 2019, View Article : Google Scholar | |
Liang Y, Xing X, Beamer MA, Swindell WR, Sarkar MK, Roberts LW, Voorhees JJ, Kahlenberg JM, Harms PW, Johnston A and Gudjonsson JE: Six-transmembrane epithelial antigens of the prostate comprise a novel inflammatory nexus in patients with pustular skin disorders. J Allergy Clin Immunol. 139:1217–1227. 2017. View Article : Google Scholar | |
Ogawa E, Sato Y, Minagawa A and Okuyama R: Pathogenesis of psoriasis and development of treatment. J Dermatol. 45:264–272. 2018. View Article : Google Scholar | |
Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, Burg G, Liu YJ and Gilliet M: Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med. 202:135–143. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mudigonda P, Mudigonda T, Feneran AN, Alamdari HS, Sandoval L and Feldman SR: Interleukin-23 and interleukin-17: Importance in pathogenesis and therapy of psoriasis. Dermatol Online J. 18:12012.PubMed/NCBI | |
Coimbra S, Oliveira H, Reis F, Belo L, Rocha S, Quintanilha A, Figueiredo A, Teixeira F, Castro E, Rocha-Pereira P and Santos-Silva A: Interleukin (IL)-22, IL-17, IL-23, IL-8, vascular endothelial growth factor and tumour necrosis factor-α levels in patients with psoriasis before, during and after psoralen-ultraviolet A and narrowband ultraviolet B therapy. Br J Dermatol. 163:1282–1290. 2010. View Article : Google Scholar : PubMed/NCBI | |
Grine L, Dejager L, Libert C and Vandenbroucke RE: An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17. Cytokine Growth Factor Rev. 26:25–33. 2015. View Article : Google Scholar | |
Fanoni D, Venegoni L, Vergani B, Tavecchio S, Cattaneo A, Leone BE, Berti E and Marzano AV: Evidence for a role of auto-inflammation in early-phase psoriasis. Clin Exp Immunol. 198:283–291. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hüffmeier U, Wätzold M, Mohr J, Schön MP and Mössner R: Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations. Br J Dermatol. 170:202–204. 2014. View Article : Google Scholar | |
Mansouri B, Richards L and Menter A: Treatment of two patients with generalized pustular psoriasis with the interleukin-1β inhibitor gevokizumab. Br J Dermatol. 173:239–241. 2015. View Article : Google Scholar | |
Skendros P, Papagoras C, Lefaki I, Giatromanolaki A, Kotsianidis I, Speletas M, Bocly V, Theodorou I, Dalla V and Ritis K: Successful response in a case of severe pustular psoriasis after interleukin-1β inhibition. Br J Dermatol. 176:212–215. 2017. View Article : Google Scholar | |
Bachelez H, Choon SE, Marrakchi S, Burden AD, Tsai TF, Morita A, Turki H, Hall DB, Shear M, Baum P, et al: Inhibition of the interleukin-36 pathway for the treatment of generalized pustular psoriasis. N Engl J Med. 380:981–983. 2019. View Article : Google Scholar : PubMed/NCBI | |
Fialová J, Vojáčková N, Vaňousová D and Hercogová J: Juvenile generalized pustular psoriasis treated with etanercept. Dermatol Ther. 27:105–108. 2014. View Article : Google Scholar : PubMed/NCBI | |
Esposito M, Mazzotta A, Casciello C and Chimenti S: Etanercept at different dosages in the treatment of generalized pustular psoriasis: A case series. Dermatology. 216:355–360. 2008. View Article : Google Scholar : PubMed/NCBI | |
Viguier M, Aubin F, Delaporte E, Pagès C, Paul C, Beylot-Barry M, Goujon C, Rybojad M and Bachelez H; Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie: Efficacy and safety of tumor necrosis factor inhibitors in acute generalized pustular psoriasis. Arch Dermatol. 148:1423–1425. 2012. View Article : Google Scholar : PubMed/NCBI | |
Saikaly SK and Mattes M: Biologics and pediatric generalized pustular psoriasis: An emerging therapeutic trend. Cureus. 8:e6522016.PubMed/NCBI | |
Cuperus E, Koevoets R, van der Smagt JJ, Toonstra J, de Graaf M, Frenkel J and Pasmans SGMA: Juvenile interleukin-36 receptor antagonist deficiency (DITRA) with c.80T>C (p.Leu27Pro) mutation successfully treated with etanercept and acitretin. JAAD Case Rep. 4:192–195. 2018. View Article : Google Scholar : PubMed/NCBI | |
Adachi A, Komine M, Hirano T, Tsuda H, Karakawa M, Murata S and Ohtsuki M: Case of generalized pustular psoriasis exacerbated during pregnancy, successfully treated with infliximab. J Dermatol. 43:1439–1440. 2016. View Article : Google Scholar : PubMed/NCBI | |
Pan J, Qiu L, Xiao T and Chen HD: Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab. Dermatol Ther. 29:164–167. 2016. View Article : Google Scholar | |
Morita A, Yamazaki F, Matsuyama T, Takahashi K, Arai S, Asahina A, Imafuku S, Nakagawa H, Hasegawa Y, Williams D, et al: Adalimumab treatment in Japanese patients with generalized pustular psoriasis: Results of an open-label phase 3 study. J Dermatol. 45:1371–1380. 2018. View Article : Google Scholar : PubMed/NCBI | |
Matsumoto A, Komine M, Karakawa M, Kishimoto M and Ohtsuki M: Adalimumab administration after infliximab therapy is a successful treatment strategy for generalized pustular psoriasis. J Dermatol. 44:202–204. 2017. View Article : Google Scholar | |
Egawa G, Honda T and Kabashima K: Long-term efficacy of ixekizumab in erythrodermic and generalized pustular psoriasis patients. J Eur Acad Dermatol Venereol. 33:2592019. View Article : Google Scholar : PubMed/NCBI | |
Wilsmann-Theis D, Schnell LM, Ralser-Isselstein V, Bieber T, Schön MP, Hüffmeier U and Mössner R: Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations. J Dermatol. 45:850–854. 2018. View Article : Google Scholar : PubMed/NCBI | |
Okubo Y, Mabuchi T, Iwatsuki K, Elmaraghy H, Torisu-Itakura H, Morisaki Y and Nakajo K: Long-term efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis: Subgroup analyses of an open-label, phase 3 study (UNCOVER-J). J Eur Acad Dermatol Venereol. 33:325–332. 2019. View Article : Google Scholar | |
Ho PH and Tsai TF: Successful treatment of refractory juvenile generalized pustular psoriasis with secukinumab monotherapy: A case report and review of published work. J Dermatol. 45:1353–1356. 2018. View Article : Google Scholar : PubMed/NCBI | |
Imafuku S, Honma M, Okubo Y, Komine M, Ohtsuki M, Morita A, Seko N, Kawashima N, Ito S, Shima T and Nakagawa H: Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multi-center Japanese study. J Dermatol. 43:1011–1017. 2016. View Article : Google Scholar : PubMed/NCBI | |
Gabeff R, Safar R, Leducq S, Maruani A, Sarrabay G, Touitou I and Samimi M: Successful therapy with secukinumab in a patient with generalized pustular psoriasis carrying homozygous IL36RN p.His32Arg mutation. Int J Dermatol. 58:e16–e17. 2019. View Article : Google Scholar | |
Yamasaki K, Nakagawa H, Kubo Y and Ootaki K; Japanese Brodalumab Study Group: Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: Results from a 52-week, open-label study. Br J Dermatol. 176:741–751. 2017. View Article : Google Scholar | |
Storan ER, O'Gorman SM and Markham T: Generalized pustular psoriasis treated with ustekinumab. Clin Exp Dermatol. 41:689–690. 2016. View Article : Google Scholar : PubMed/NCBI | |
Arakawa A, Ruzicka T and Prinz JC: Therapeutic efficacy of interleukin 12/interleukin 23 blockade in generalized pustular psoriasis regardless of IL36RN mutation status. JAMA Dermatol. 152:825–828. 2016. View Article : Google Scholar : PubMed/NCBI | |
Viguier M, Guigue P, Pages C, Smahi A and Bachelez H: Successful treatment of generalized pustular psoriasis with the interleukin-1-receptor antagonist Anakinra: Lack of correlation with IL1RN mutations. Ann Intern Med. 153:66–67. 2010. View Article : Google Scholar : PubMed/NCBI |