Open Access

Roles of long non‑coding RNA in osteoarthritis (Review)

  • Authors:
    • Jicheng Wang
    • Yanshan Sun
    • Jianyong Liu
    • Bo Yang
    • Tengyun Wang
    • Zhen Zhang
    • Xin Jiang
    • Yongzhi Guo
    • Yangyang Zhang
  • View Affiliations

  • Published online on: May 19, 2021     https://doi.org/10.3892/ijmm.2021.4966
  • Article Number: 133
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is a chronic bone and joint disease characterized by articular cartilage degeneration and joint inflammation and is the most common form of arthritis. The clinical manifestations of OA are chronic pain and joint activity disorder, which severely affect the patient quality of life. Long non‑coding RNA (lncRNA) is a class of RNA molecules >200 nucleotides long that are expressed in animals, plants, yeast, prokaryotes and viruses. lncRNA molecules lack an open reading frame and are not translated into protein. The present review collated the results of recent studies on the role of lncRNA in the pathogenesis of OA to provide information for the prevention, diagnosis and treatment of OA.
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July-2021
Volume 48 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Sun Y, Liu J, Yang B, Wang T, Zhang Z, Jiang X, Guo Y and Zhang Y: Roles of long non‑coding RNA in osteoarthritis (Review). Int J Mol Med 48: 133, 2021.
APA
Wang, J., Sun, Y., Liu, J., Yang, B., Wang, T., Zhang, Z. ... Zhang, Y. (2021). Roles of long non‑coding RNA in osteoarthritis (Review). International Journal of Molecular Medicine, 48, 133. https://doi.org/10.3892/ijmm.2021.4966
MLA
Wang, J., Sun, Y., Liu, J., Yang, B., Wang, T., Zhang, Z., Jiang, X., Guo, Y., Zhang, Y."Roles of long non‑coding RNA in osteoarthritis (Review)". International Journal of Molecular Medicine 48.1 (2021): 133.
Chicago
Wang, J., Sun, Y., Liu, J., Yang, B., Wang, T., Zhang, Z., Jiang, X., Guo, Y., Zhang, Y."Roles of long non‑coding RNA in osteoarthritis (Review)". International Journal of Molecular Medicine 48, no. 1 (2021): 133. https://doi.org/10.3892/ijmm.2021.4966