1
|
Lau EMT, Giannoulatou E, Celermajer DS and
Humbert M: Epidemiology and treatment of pulmonary arterial
hypertension. Nat Rev Cardiol. 14:603–614. 2017. View Article : Google Scholar
|
2
|
Thenappan T, Ryan JJ and Archer SL:
Evolving epidemiology of pulmonary arterial hypertension. Am J
Respir Crit Care Med. 186:707–709. 2012. View Article : Google Scholar
|
3
|
Zolty R: Pulmonary arterial hypertension
specific therapy: The old and the new. Pharmacol Ther.
214:1075762020. View Article : Google Scholar
|
4
|
Xu L, Ma Y, Zhang H, Lu QJ, Yang L, Jiang
GN and Liao WL: HMGA2 regulates circular RNA ASPH to promote tumor
growth in lung adenocarcinoma. Cell Death Dis. 11:5932020.
View Article : Google Scholar
|
5
|
Mulvaney EP, Reid HM, Bialesova L,
Mendes-Ferreira P, Adão R, Brás-Silva C and Kinsella BT: Efficacy
of the thromboxane receptor antagonist NTP42 alone, or in
combination with sildenafil, in the sugen/hypoxia-induced model of
pulmonary arterial hypertension. Eur J Pharmacol. 889:1736582020.
View Article : Google Scholar
|
6
|
Sitbon O, Gomberg-Maitland M, Granton J,
Lewis MI, Mathai SC, Rainisio M, Stockbridge NL, Wilkins MR,
Zamanian RT and Rubin LJ: Clinical trial design and new therapies
for pulmonary arterial hypertension. Eur Respir J. 53:18019082019.
View Article : Google Scholar
|
7
|
McLaughlin VV, Hoeper MM, Channick RN,
Chin KM, Delcroix M, Gaine S, Ghofrani HA, Jansa P, Lang IM, Mehta
S, et al: Pulmonary arterial hypertension-related morbidity is
prognostic for mortality. J Am Coll Cardiol. 71:752–763. 2018.
View Article : Google Scholar
|
8
|
Galiè N, Humbert M, Vachiery JL, Gibbs S,
Lang I, Torbicki A, Simonneau G, Peacock A, Noordegraaf AV,
Beghetti M, et al: 2015 ESC/ERS guidelines for the diagnosis and
treatment of pulmonary hypertension. Rev Esp Cardiol (Engl Ed).
69:1772016. View Article : Google Scholar
|
9
|
Chaabane M, Andreeva K, Hwang JY, Kook TL,
Park JW and Cooper NGF: seekCRIT: Detecting and characterizing
differentially expressed circular RNAs using high-throughput
sequencing data. PLoS Comput Biol. 16:e10083382020. View Article : Google Scholar
|
10
|
Du H, He Z, Feng F, Chen D, Zhang L, Bai
J, Wu H, Han E and Zhang J: Hsa_circ_0038646 promotes cell
proliferation and migration in colorectal cancer via
miR-331-3p/GRIK3. Oncol Lett. 20:266–274. 2020.
|
11
|
Song R, Li Y, Hao W, Yang L, Chen B, Zhao
Y, Sun B and Xu F: Circular RNA MTO1 inhibits gastric cancer
progression by elevating PAWR via sponging miR-199a-3p. Cell Cycle.
19:3127–3139. 2020. View Article : Google Scholar
|
12
|
Altesha MA, Ni T, Khan A, Liu K and Zheng
X: Circular RNA in cardiovascular disease. J Cell Physiol.
234:5588–5600. 2019. View Article : Google Scholar
|
13
|
Boon RA, Jaé N, Holdt L and Dimmeler S:
Long noncoding RNAs: From clinical genetics to therapeutic targets?
J Am Coll Cardiol. 67:1214–1226. 2016. View Article : Google Scholar
|
14
|
Miao R, Wang Y, Wan J, Leng D, Gong J, Li
J, Liang Y, Zhai Z and Yang Y: Microarray expression profile of
circular RNAs in chronic thromboembolic pulmonary hypertension.
Medicine (Baltimore). 96:e73542017. View Article : Google Scholar
|
15
|
Wang Y, Tan X, Wu Y, Cao S, Lou Y, Zhang L
and Hu F: Hsa_ circ_0002062 promotes the proliferation of pulmonary
artery smooth muscle cells by regulating the Hsa-miR-942-5p/CDK6
signaling pathway. Front Genet. 12:–673229. 2021.
|
16
|
Yang L, Liang H, Meng X, Shen L, Guan Z,
Hei B, Yu H, Qi S and Wen X: mmu_circ_0000790 is involved in
pulmonary vascular remodeling in mice with HPH via
microRNA-374c-mediated FOXC1. Mol Ther Nucleic Acids. 20:292–307.
2020. View Article : Google Scholar
|
17
|
Abdelmohsen K, Panda AC, Munk R,
Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM,
Martindale JL and Gorospe M: Identification of HuR target circular
RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA
Biol. 14:361–369. 2017. View Article : Google Scholar
|
18
|
Du WW, Fang L, Yang W, Wu N, Awan FM, Yang
Z and Yang BB: Induction of tumor apoptosis through a circular RNA
enhancing Foxo3 activity. Cell Death Differ. 24:357–370. 2017.
View Article : Google Scholar
|
19
|
Wang J, Song YX, Ma B, Wang JJ, Sun JX,
Chen XW, Zhao JH, Yang YC and Wang ZN: Regulatory roles of
non-coding RNAs in colorectal cancer. Int J Mol Sci.
16:19886–19919. 2015. View Article : Google Scholar
|
20
|
Fan YN, Li C, Huang L, Chen L, Tang Z, Han
G and Liu Y: Characterization of group I metabotropic glutamate
receptors in rat and human adrenal glands. Front Physiol.
11:4012020. View Article : Google Scholar
|
21
|
Khan AJ, LaCava S, Mehta M, Schiff D,
Thandoni A, Jhawar S, Danish S, Haffty BG and Chen S: The glutamate
release inhibitor riluzole increases DNA damage and enhances
cytotoxicity in human glioma cells, in vitro and in vivo.
Oncotarget. 10:2824–2834. 2019. View Article : Google Scholar
|
22
|
Namkoong J, Martino JJ and Chen S: From
existing therapies to novel targets: A current view on melanoma.
Front Biosci. 11:2081–2092. 2006. View
Article : Google Scholar
|
23
|
Yip D, Le MN, Chan JL, Lee JH, Mehnert JA,
Yudd A, Kempf J, Shih WJ, Chen S and Goydos JS: A phase 0 trial of
riluzole in patients with resectable stage III and IV melanoma.
Clin Cancer Res. 15:3896–3902. 2009. View Article : Google Scholar
|
24
|
Wang R, Xu YJ, Liu XS, Zeng DX and Xiang
M: Knockdown of connective tissue growth factor by plasmid-based
short hairpin RNA prevented pulmonary vascular remodeling in
cigarette smoke-exposed rats. Arch Biochem Biophys. 508:93–100.
2011. View Article : Google Scholar
|
25
|
Wang R, Xu YJ, Liu XS, Zeng DX and Xiang
M: CCN2 promotes cigarette smoke-induced proliferation of rat
pulmonary artery smooth muscle cells through upregulating cyclin D1
expression. J Cell Biochem. 113:349–359. 2012. View Article : Google Scholar
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
27
|
Kong W, Wei J, Abidi P, Lin M, Inaba S, Li
C, Wang Y, Wang Z, Si S, Pan H, et al: Berberine is a novel
cholesterol-lowering drug working through a unique mechanism
distinct from statins. Nat Med. 10:1344–1351. 2004. View Article : Google Scholar
|
28
|
Muller C, Goubin F, Ferrandis E,
Cornil-Scharwtz I, Bailly JD, Bordier C, Bénard J, Sikic BI and
Laurent G: Evidence for transcriptional control of human mdr1 gene
expression by verapamil in multidrug-resistant leukemic cells. Mol
Pharmacol. 47:51–56. 1995.
|
29
|
Yu G, Wang LG, Han Y and He QY:
clusterProfiler: An R package for comparing biological themes among
gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar
|
30
|
Deng WG, Kawashima H, Wu G, Jayachandran
G, Xu K, Minna JD, Roth JA and Ji L: Synergistic tumor suppression
by coexpression of FUS1 and p53 is associated with down-regulation
of murine double minute-2 and activation of the apoptotic
protease-activating factor 1-dependent apoptotic pathway in human
non-small cell lung cancer cells. Cancer Res. 67:709–717. 2007.
View Article : Google Scholar
|
31
|
Hesson LB, Cooper WN and Latif F:
Evaluation of the 3p213 tumour-suppressor gene cluster. Oncogene.
26:7283–7301. 2007. View Article : Google Scholar
|
32
|
Ji L and Roth JA: Tumor suppressor FUS1
signaling pathway. J Thorac Oncol. 3:327–330. 2008. View Article : Google Scholar
|
33
|
Lin J, Sun T, Ji L, Deng W, Roth J, Minna
J and Arlinghaus R: Oncogenic activation of c-Abl in non-small cell
lung cancer cells lacking FUS1 expression: Inhibition of c-Abl by
the tumor suppressor gene product Fus1. Oncogene. 26:6989–6996.
2007. View Article : Google Scholar
|
34
|
Zou Z, Ma T, He X, Zhou J, Ma H, Xie M,
Liu Y, Lu D, Di S and Zhang Z: Long intergenic non-coding RNA 00324
promotes gastric cancer cell proliferation via binding with HuR and
stabilizing FAM83B expression article. Cell Death Dis. 9:7172018.
View Article : Google Scholar
|
35
|
Du WW, Zhang C, Yang W, Yong T, Awan FM
and Yang BB: Identifying and characterizing circRNA-protein
interaction. Theranostics. 7:4183–4191. 2017. View Article : Google Scholar
|
36
|
Hentze MW and Preiss T: Circular RNAs:
Splicing's enigma variations. EMBO J. 32:923–925. 2013. View Article : Google Scholar
|
37
|
Li YX, Run L, Shi T and Zhang YJ: CTRP9
regulates hypoxia-mediated human pulmonary artery smooth muscle
cell proliferation, apoptosis and migration via TGF-β1/ERK1/2
signaling pathway. Biochem Biophys Res Commun. 490:1319–1325. 2017.
View Article : Google Scholar
|
38
|
You B, Liu Y, Chen J, Huang X, Peng H, Liu
Z, Tang Y, Zhang K, Xu Q, Li X, et al: Vascular peroxidase 1
mediates hypoxia-induced pulmonary artery smooth muscle cell
proliferation, apoptosis resistance and migration. Cardiovasc Res.
114:188–199. 2018. View Article : Google Scholar
|
39
|
Naeije R and Dedobbeleer C: Pulmonary
hypertension and the right ventricle in hypoxia. Exp Physiol.
98:1247–1256. 2013. View Article : Google Scholar
|
40
|
Ghofrani HA, Voswinckel R, Reichenberger
F, Weissmann N, Schermuly RT, Seeger W and Grimminger F: Hypoxia-
and non-hypoxia-related pulmonary hypertension-established and new
therapies. Cardiovasc Res. 72:30–40. 2006. View Article : Google Scholar
|
41
|
Zhou S, Jiang H, Li M, Wu P, Sun L, Liu Y,
Zhu K, Zhang B, Sun G, Cao C and Wang R: Circular RNA
hsa_circ_0016070 is associated with pulmonary arterial hypertension
by promoting PASMC proliferation. Mol Ther Nucleic Acids.
18:275–284. 2019. View Article : Google Scholar
|
42
|
Beltrán-García J, Osca-Verdegal R,
Nácher-Sendra E, Cardona-Monzonís A, Sanchis-Gomar F, Carbonell N,
Pallardó FV, Lavie CJ and García-Giménez JL: Role of non-coding
RNAs as biomarkers of deleterious cardiovascular effects in sepsis.
Prog Cardiovasc Dis. Jul 13–2021.Epub ahead of print. View Article : Google Scholar
|
43
|
Li R, Jiang Q and Zheng Y: Circ_0002984
induces proliferation, migration and inflammation response of VSMCs
induced by ox-LDL through miR-326-3p/VAMP3 axis in atherosclerosis.
J Cell Mol Med. 25:8028–8038. 2021. View Article : Google Scholar
|
44
|
Wang F and Zhang M: Circ_001209 aggravates
diabetic retinal vascular dysfunction through regulating
miR-15b-5p/COL12A1. J Transl Med. 19:2942021. View Article : Google Scholar
|
45
|
Zhu QQ, Pu XB, Chen TC, Qiu CY, Wu ZH,
Tian L, He YY, Wang XH, Shang T, Wang X, et al: Hsa_circ_0008360
sponges miR-186-5p to target CCND2 to modulate high glucose-induced
vascular endothelial dysfunction. Cell Cycle. 20:1389–1401. 2021.
View Article : Google Scholar
|
46
|
Guo HM and Liu ZP: Up-regulation of
circRNA_0068481 promotes right ventricular hypertrophy in PAH
patients via regulating miR-646/miR-570/miR-885. J Cell Mol Med.
25:3735–3743. 2021. View Article : Google Scholar
|
47
|
Hong L, Ma X, Liu J, Luo Y, Lin J, Shen Y
and Zhang L: Circular RNA-HIPK3 regulates human pulmonary artery
endothelial cells function and vessel growth by regulating
microRNA-328-3p/STAT3 axis. Pulm Circ. 11:204589402110002342021.
View Article : Google Scholar
|
48
|
Yang T, Long T, Du T, Chen Y, Dong Y and
Huang ZP: Circle the cardiac remodeling with circRNAs. Front
Cardiovasc Med. 8:7025862021. View Article : Google Scholar
|
49
|
Ali S, Shourideh M and Koochekpour S:
Identification of novel GRM1 mutations and single nucleotide
polymorphisms in prostate cancer cell lines and tissues. PLoS One.
9:e1032042014. View Article : Google Scholar
|
50
|
Thandi S, Blank JL and Challiss RAJ:
Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple
to extracellular signal-regulated kinase (ERK) activation via
distinct, but overlapping, signalling pathways. J Neurochem.
83:1139–1153. 2002. View Article : Google Scholar
|
51
|
Inamdar GS, Madhunapantula SRV and
Robertson GP: Targeting the MAPK pathway in melanoma: Why some
approaches succeed and other fail. Biochem Pharmacol. 80:624–637.
2010. View Article : Google Scholar
|
52
|
Pearson G, Robinson F, Beers Gibson T, Xu
BE, Karandikar M, Berman K and Cobb MH: Mitogen-activated protein
(MAP) kinase pathways: Regulation and physiological functions.
Endocr Rev. 22:153–183. 2001.
|
53
|
Cui J and Placzek WJ: PTBP1 modulation of
MCL1 expression regulates cellular apoptosis induced by antitubulin
chemotherapeutics. Cell Death Differ. 23:1681–1690. 2016.
View Article : Google Scholar
|
54
|
Zhao Y, Liu Y, Lin L, Huang Q, He W, Zhang
S, Dong S, Wen Z, Rao J, Liao W and Shi M: The lncRNA MACC1-AS1
promotes gastric cancer cell metabolic plasticity via AMPK/Lin28
mediated mRNA stability of MACC1. Mol Cancer. 17:692018. View Article : Google Scholar
|
55
|
Zhu B, Cao A, Li J, Young J, Wong J,
Ashraf S, Bierzynska A, Menon MC, Hou S, Sawyers C, et al:
Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte
dysfunction in congenital nephrotic syndrome caused by mutations in
MAGI2. Kidney Int. 96:642–655. 2019. View Article : Google Scholar
|
56
|
Liang D, Xiang L, Yang M, Zhang X, Guo B,
Chen Y, Yang L and Cao J: ZnT7 can protect MC3T3-E1 cells from
oxidative stress-induced apoptosis via PI3K/Akt and MAPK/ERK
signaling pathways. Cell Signal. 25:1126–1135. 2013. View Article : Google Scholar
|
57
|
Ma H, Han F, Yan X, Qi G, Li Y, Li R, Yan
S, Yuan C, Song K and Kong B: PBK promotes aggressive phenotypes of
cervical cancer through ERK/c-Myc signaling pathway. J Cell
Physiol. 236:2767–2781. 2020. View Article : Google Scholar
|
58
|
Nikam VS, Wecker G, Schermuly R, Rapp U,
Szelepusa K, Seeger W and Voswinckel R: Treprostinil inhibits the
adhesion and differentiation of fibrocytes via the cyclic adenosine
monophosphate-dependent and Ras-proximate protein-dependent
inactivation of extracellular regulated kinase. Am J Respir Cell
Mol Biol. 45:692–703. 2011. View Article : Google Scholar
|
59
|
Li Q, Teng Y, Wang J, Yu M, Li Y and Zheng
H: Rap1 promotes proliferation and migration of vascular smooth
muscle cell via the ERK pathway. Pathol Res Pract. 214:1045–1050.
2018. View Article : Google Scholar
|