Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)
- Authors:
- Siti Muslihah Abd Radzak
- Siti Zulaikha Nashwa Mohd Khair
- Farizan Ahmad
- Azim Patar
- Zamzuri Idris
- Abdul Aziz Mohamed Yusoff
-
Affiliations: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, Malaysia - Published online on: June 16, 2022 https://doi.org/10.3892/ijmm.2022.5160
- Article Number: 104
-
Copyright: © Abd Radzak et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI | |
Moon JJ, Lu A and Moon C: Role of genomic instability in human carcinogenesis. Exp Biol Med (Maywood). 244:227–240. 2019. View Article : Google Scholar : PubMed/NCBI | |
Pikor L, Thu K, Vucic E and Lam W: The detection and implication of genome instability in cancer. Cancer Metastasis Rev. 32:341–352. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yusoff AAM, Abdullah WSW, Khair SZNM and Radzak SMA: A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies. Oncol Rev. 13:4092019.PubMed/NCBI | |
Otto AM: Warburg effect(s)-a biographical sketch of Otto Warburg and his impacts on tumor metabolism. Cancer Metab. 4:52016. View Article : Google Scholar : PubMed/NCBI | |
Modica-Napolitano JS, Kulawiec M and Singh K: Mitochondria and human cancer. Curr Mol Med. 7:121–131. 2007. View Article : Google Scholar : PubMed/NCBI | |
Chen EI: Mitochondrial dysfunction and cancer metastasis. J Bioenerg Biomembr. 44:619–622. 2012. View Article : Google Scholar : PubMed/NCBI | |
Pedersen PL: Bioenergetics of cancer cells-a brief orientation to this minireview series. J Bioenerg Biomembr. 29:301–302. 1997. View Article : Google Scholar : PubMed/NCBI | |
Rempel A, Mathupala SP, Griffin CA, Hawkins AL and Pedersen PL: Glucose catabolism in cancer cells: Amplification of the gene encoding type II hexokinase. Cancer Res. 56:2468–2471. 1996.PubMed/NCBI | |
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, et al: Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol. 292:125–C136. 2007. View Article : Google Scholar : PubMed/NCBI | |
Radzak S, Khair Z, Ahmad F, Idris Z and Yusoff A: Accumulation of mitochondrial DNA microsatellite instability in Malaysian patients with primary central nervous system tumors. Turk Neurosurg. 31:99–106. 2021.PubMed/NCBI | |
Campa D, Barrdahl M, Santoro A, Severi G, Baglietto L, Omichessan H, Tumino R, Bueno-de-Mesquita HBA, Peeters PH, Weiderpass E, et al: Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. Breast Cancer Res. 20:292018. View Article : Google Scholar : PubMed/NCBI | |
Dai JG, Zhang ZY, Liu QX and Min JX: Mitochondrial genome microsatellite instability and copy number alteration in lung carcinomas. Asian Pacific J Cancer Prev. 14:2393–2399. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kumar B, Bhat ZI, Bansal S, Saini S, Naseem A, Wahabi K, Burman A, Kumar GT, Saluja SS and Rizvi MMA: Association of mitochondrial copy number variation and T16189C polymorphism with colorectal cancer in North Indian population. Tumour Biol. 39:10104283177402962017. View Article : Google Scholar : PubMed/NCBI | |
Zhao RZ, Jiang S, Zhang L and Yu ZB: Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med. 44:3–15. 2019.PubMed/NCBI | |
Zhu X, Mao Y, Huang T, Yan C, Yu F, Du J, Dai J, Ma H and Jin G: High mitochondrial DNA copy number was associated with an increased gastric cancer risk in a Chinese population. Mol Carcinog. 56:2593–2600. 2017. View Article : Google Scholar : PubMed/NCBI | |
Gilkerson R, Bravo L, Garcia I, Gaytan N, Herrera A, Maldonado A and Quintanilla B: The mitochondrial nucleoid: Integrating mitochondrial DNA into cellular homeostasis. Cold Spring Harb Perspect Biol. 5:a0110802013. View Article : Google Scholar : PubMed/NCBI | |
Facucho-Oliveira JM and St John JC: The relationship between pluripotency and mitochondrial DNA proliferation during early embryo development and embryonic stem cell differentiation. Stem Cell Rev Rep. 5:140–158. 2009. View Article : Google Scholar : PubMed/NCBI | |
Montoya J, Christianson T, Levens D, Rabinowitz M and Attardi G: Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA. Proc Natl Acad Sci USA. 79:7195–7199. 1982. View Article : Google Scholar : PubMed/NCBI | |
Clayton DA: Transcription and replication of mitochondrial DNA. Hum Reprod. 15 (Suppl 2):S11–S17. 2000. View Article : Google Scholar | |
Turnbull HE, Lax NZ, Diodato D, Ansorge O and Turnbull DM: The mitochondrial brain: From mitochondrial genome to neurodegeneration. Biochim Biophys Acta. 1802:111–121. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chabi B, Mousson De Camaret B, Duborjal H, Issartel JP and Stepien G: Quantification of mitochondrial DNA deletion, depletion, and overreplication: Application to diagnosis. Clin Chem. 49:1309–1317. 2003. View Article : Google Scholar : PubMed/NCBI | |
Castellani CA, Longchamps RJ, Sun J, Guallar E and Arking DE: Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease. Mitochondrion. 53:214–223. 2020. View Article : Google Scholar : PubMed/NCBI | |
D'Erchia AM, Atlante A, Gadaleta G, Pavesi G, Chiara M, De Virgilio C, Manzari C, Mastropasqua F, Prazzoli GM, Picardi E, et al: Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity. Mitochondrion. 20:13–21. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chen X, Prosser R, Simonetti S, Sadlock J, Jagiello G and Schon EA: Rearranged mitochondrial genomes are present in human oocytes. Am J Hum Genet. 57:239–247. 1995.PubMed/NCBI | |
Yusoff AA, Ahmad F, Idris Z, Jaafar H and Abdullah JM: Understanding mitochondrial DNA in brain tumorigenesis. Mol Considerations Evol Surg Manag Issues Treat Patients with a Brain Tumor. 3–28. 2015. | |
Fontana GA and Gahlon HL: Mechanisms of replication and repair in mitochondrial DNA deletion formation. Nucleic Acids Res. 48:11244–11258. 2020. View Article : Google Scholar : PubMed/NCBI | |
Robberson DL, Kasamatsu H and Vinograd J: Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells. Proc Natl Acad Sci USA. 69:737–741. 1972. View Article : Google Scholar : PubMed/NCBI | |
Holt IJ, Lorimer HE and Jacobs HT: Coupled leading-and lagging-strand synthesis of mammalian mitochondrial DNA. Cell. 100:515–524. 2000. View Article : Google Scholar : PubMed/NCBI | |
Yasukawa T, Reyes A, Cluett TJ, Yang MY, Bowmaker M, Jacobs HT and Holt IJ: Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. EMBO J. 25:5358–5371. 2006. View Article : Google Scholar : PubMed/NCBI | |
Clay Montier LL, Deng JJ and Bai Y: Number matters: Control of mammalian mitochondrial DNA copy number. J Genet Genomics. 36:125–131. 2009. View Article : Google Scholar : PubMed/NCBI | |
Falkenberg M: Mitochondrial DNA replication in mammalian cells: Overview of the pathway. Essays Biochem. 62:287–296. 2018. View Article : Google Scholar : PubMed/NCBI | |
Larsson NG, Wang J, Wilhelmsson H, Oldfors A, Rustin P, Lewandoski M, Barsh GS and Clayton DA: Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet. 18:231–236. 1998. View Article : Google Scholar : PubMed/NCBI | |
Kanki T, Ohgaki K, Gaspari M, Gustafsson CM, Fukuoh A, Sasaki N, Hamasaki N and Kang D: Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Mol Cell Biol. 24:9823–9834. 2004. View Article : Google Scholar : PubMed/NCBI | |
Ekstrand MI, Falkenberg M, Rantanen A, Park CB, Gaspari M, Hultenby K, Rustin P, Gustafsson CM and Larsson NG: Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Hum Mol Genet. 13:935–944. 2004. View Article : Google Scholar : PubMed/NCBI | |
Farge G, Mehmedovic M, Baclayon M, van den Wildenberg SM, Roos WH, Gustafsson CM, Wuite GJ and Falkenberg M: In vitro-reconstituted nucleoids can block mitochondrial DNA replication and transcription. Cell Rep. 8:66–74. 2014. View Article : Google Scholar : PubMed/NCBI | |
Korhonen JA, Pham XH, Pellegrini M and Falkenberg M: Reconstitution of a minimal mtDNA replisome in vitro. EMBO J. 23:2423–2429. 2004. View Article : Google Scholar : PubMed/NCBI | |
Peter B and Falkenberg M: Twinkle and other human mitochondrial DNA helicases: Structure, function and disease. Genes (Basel). 11:4082020. View Article : Google Scholar : PubMed/NCBI | |
Korhonen JA, Gaspari M and Falkenberg M: Twinkle has 5′ ->3′ DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein. J Biol Chem. 278:48627–48632. 2003. View Article : Google Scholar : PubMed/NCBI | |
Milenkovic D, Matic S, kühl I, Ruzzenente B, Freyer C, Jemt E, Park CB, Falkenberg M and Larsson NG: Twinkle is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet. 22:1983–1993. 2013. View Article : Google Scholar : PubMed/NCBI | |
Takamatsu C, Umeda S, Ohsato T, Ohno T, Abe Y, Fukuoh A, Shinagawa H, Hamasaki N and Kang D: Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. EMBO Rep. 3:451–456. 2002. View Article : Google Scholar : PubMed/NCBI | |
Miralles Fusté J, Shi Y, Wanrooij S, Zhu X, Jemt E, Persson Ö, Sabouri N, Gustafsson CM and Falkenberg M: In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication. PLoS Genet. 10:e10048322014. View Article : Google Scholar : PubMed/NCBI | |
Datta A and Brosh RM Jr: New insights into DNA helicases as druggable targets for cancer therapy. Front Mol Biosci. 5:592018. View Article : Google Scholar : PubMed/NCBI | |
Ruhanen H, Borrie S, Szabadkai G, Tyynismaa H, Jones AW, Kang D, Taanman JW and Yasukawa T: Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation. Biochim Biophys Acta. 1803:931–939. 2010. View Article : Google Scholar : PubMed/NCBI | |
Grzybowska-Szatkowska L and Slaska B: Mitochondrial DNA and carcinogenesis (review). Mol Med Rep. 6:923–930. 2012. View Article : Google Scholar : PubMed/NCBI | |
Reddy TV, Govatati S, Deenadayal M, Sisinthy S and Bhanoori M: Impact of mitochondrial DNA copy number and displacement loop alterations on polycystic ovary syndrome risk in south Indian women. Mitochondrion. 44:35–40. 2019. View Article : Google Scholar : PubMed/NCBI | |
Li HL, Slone J, Fei L and Huang T: Mitochondrial DNA variants and common diseases: A mathematical model for the diversity of age-related mtDNA mutations. Cells. 8:6082019. View Article : Google Scholar : PubMed/NCBI | |
Nicholls TJ and Minczuk M: In D-loop: 40 years of mitochondrial 7S DNA. Exp Gerontol. 56:175–181. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lee HC, Li SH, Lin JC, Wu CC, Yeh DC and Wei YH: Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutat Res. 547:71–78. 2004. View Article : Google Scholar : PubMed/NCBI | |
Yu M, Wan Y and Zou Q: Decreased copy number of mitochondrial DNA in Ewing's sarcoma. Clin Chim Acta. 411:679–683. 2010. View Article : Google Scholar : PubMed/NCBI | |
Yu M, Zhou Y, Shi Y, Ning L, Yang Y, Wei X and Zhang N: Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life. 59:450–457. 2007. View Article : Google Scholar : PubMed/NCBI | |
Bai R, Chang J, Yeh K, Lou MA, Lu JF, Tan DJ, Liu H and Wong LJ: Mitochondrial DNA content varies with pathological characteristics of breast cancer. J Oncol. 2011:4961892011. View Article : Google Scholar : PubMed/NCBI | |
Yusoff AAM, Radzak SMA and Khair SZNM: Research highlights on contributions of mitochondrial DNA microsatellite instability in solid cancers - an overview. Contemp Oncol (Pozn). 26:8–26. 2022.PubMed/NCBI | |
Kazak L, Reyes A and Holt IJ: Minimizing the damage : Repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol. 13:659–671. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhang D, Mott JL, Chang SW, Denniger G, Feng Z and Zassenhaus HP: Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis. Genomics. 69:151–161. 2000. View Article : Google Scholar : PubMed/NCBI | |
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, et al: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 429:417–423. 2004. View Article : Google Scholar : PubMed/NCBI | |
Spelbrink JN, Toivonen JM, Hakkaart GAJ, Kurkela JM, Cooper HM, Lehtinen SK, Lecrenier N, Back JW, Speijer D, Foury F and Jacobs HT: In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells. J Biol Chem. 275:24818–24828. 2000. View Article : Google Scholar : PubMed/NCBI | |
Singh KK, Ayyasamy V, Owens KM, Koul MS and Vujcic M: Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. J Hum Genet. 54:516–524. 2009. View Article : Google Scholar : PubMed/NCBI | |
Linkowska K, Jawien A, Marszałek A, Skonieczna K and Grzybowski T: Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer. Acta Biochim Pol. 62:625–627. 2015. View Article : Google Scholar : PubMed/NCBI | |
Long X, Wang X, Chen Y, Guo X, Zhou F, Fan Y, Ge N, Guo M, Zhang Z and Dong G: Polymorphisms in POLG were associated with the prognosis and mtDNA content in hepatocellular carcinoma patients. Bull Cancer. 104:500–507. 2017. View Article : Google Scholar : PubMed/NCBI | |
Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, et al: Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet. 28:223–231. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tyynismaa H, Sembongi H, Bokori-Brown M, Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ and Suomalainen A: Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet. 13:3219–3227. 2004. View Article : Google Scholar : PubMed/NCBI | |
Sanchez-Martinez A, Calleja M, Peralta S, Matsushima Y, Hernandez-Sierra R, Whitworth AJ, Kaguni LS and Garesse R: Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects. PLoS One. 7:e439542012. View Article : Google Scholar : PubMed/NCBI | |
Matsushima Y and Kaguni LS: Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells. J Biol Chem. 282:9436–9444. 2007. View Article : Google Scholar : PubMed/NCBI | |
Lin CS, Wang LS, Tsai CM and Wei YH: Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy. Interact Cardiovasc Thorac Surg. 7:954–958. 2008. View Article : Google Scholar : PubMed/NCBI | |
Hu L, Yao X and Shen Y: Altered mitochondrial DNA copy number contributes to human cancer risk: Evidence from an updated meta-analysis. Sci Rep. 6:358592016. View Article : Google Scholar : PubMed/NCBI | |
Lee H, Lee JH, Kim DC, Hwang I, Kang YN, Gwon GJ, Choi IJ and Kim S: Is mitochondrial DNA copy number associated with clinical characteristics and prognosis in gastric cancer? Asian Pacific J Cancer Prev. 16:87–90. 2015. View Article : Google Scholar : PubMed/NCBI | |
Han Y and Chen JZ: Oxidative stress induces mitochondrial DNA damage and cytotoxicity through independent mechanisms in human cancer cells. Biomed Res Int. 2013:8250652013. View Article : Google Scholar : PubMed/NCBI | |
Liu CS, Tsai CS, Kuo CL, Chen HW, Lii CK, Ma YS and Wei YH: Oxidative stress-related alteration of the copy number of mitochondrial DNA in human leukocytes. Free Radic Res. 37:1307–1317. 2003. View Article : Google Scholar : PubMed/NCBI | |
Al-Kafaji G and Golbahar J: High glucose-induced oxidative stress increases the copy number of mitochondrial DNA in human mesangial cells. Biomed Res Int. 2013:7549462013. View Article : Google Scholar : PubMed/NCBI | |
Guha M and Avadhani NG: Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion. 13:577–591. 2013. View Article : Google Scholar : PubMed/NCBI | |
Corral M, Paris B, Baffet G, Tichonicky L, Guguen-Guillouzo C, Kruh J and Defer N: Increased level of the mitochondrial ND5 transcript in chemically induced rat hepatomas. Exp Cell Res. 184:158–166. 1989. View Article : Google Scholar : PubMed/NCBI | |
Delsite RL, Rasmussen LJ, Rasmussen AK, Kalen A, Goswami PC and Singh KK: Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis. 18:497–503. 2003. View Article : Google Scholar : PubMed/NCBI | |
Suzuki S, Naito A, Asano T, Evans TT, Reddy SAG and Higuchi M: Constitutive activation of AKT pathway inhibits TNF-induced apoptosis in mitochondrial DNA-deficient human myelogenous leukemia ML-1a. Cancer Lett. 268:31–37. 2008. View Article : Google Scholar : PubMed/NCBI | |
Biswas G, Anandatheerthavarada HK, Zaidi M and Avadhani NG: Mitochondria to nucleus stress signaling: A distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J Cell Biol. 161:507–519. 2003. View Article : Google Scholar : PubMed/NCBI | |
Lu T and Stark GR: Cytokine overexpression and constitutive NFkappaB in cancer. Cell Cycle. 3:1114–1117. 2004. View Article : Google Scholar : PubMed/NCBI | |
Mei H, Sun S, Bai Y, Chen Y, Chai R and Li H: Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs. Cell Death Dis. 6:e17102015. View Article : Google Scholar : PubMed/NCBI | |
Sun X, Zhan L, Chen Y, Wang G, He L, Wang Q, Zhou F, Yang F, Wu J, Wu Y, et al: Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer. Signal Transduct Target Ther. 3:82018. View Article : Google Scholar : PubMed/NCBI | |
Moraes CT: What regulates mitochondrial DNA copy number in animal cells? Trends Genet. 17:199–205. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tang Y, Schon EA, Wilichowski E, Vazquez-Memije ME, Davidson E and King MP: Rearrangements of human mitochondrial DNA (mtDNA): New insights into the regulation of mtDNA copy number and gene expression. Mol Biol Cell. 11:1471–1485. 2000. View Article : Google Scholar : PubMed/NCBI | |
Tang Y, Manfredi G, Hirano M and Schon EA: Maintenance of human rearranged mitochondrial DNAs in long-term cultured transmitochondrial cell lines. Mol Biol Cell. 11:2349–2358. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kelly RD, Mahmud A, McKenzie M, Trounce IA and St John JC: Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res. 40:10124–10138. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lee W, Johnson J, Gough DJ, Donoghue J, Cagnone GL, Vaghjiani V, Brown KA, Johns TG and St John JC: Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny. Cell Death Dis. 6:e16642015. View Article : Google Scholar : PubMed/NCBI | |
Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RD, McKenzie M, Johns TG and St John JC: The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ. 20:1644–1653. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sun X and St John JC: Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours. Epigenetics Chromatin. 11:532018. View Article : Google Scholar : PubMed/NCBI | |
Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, et al: Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab. 21:81–94. 2015. View Article : Google Scholar : PubMed/NCBI | |
Berridge MV, Crasso C and Neuzil J: Mitochondrial genome transfer to tumor cells breaks the rules and establishes a new precedent in cancer biology. Mol Cell Oncol. 5:e10239292018. View Article : Google Scholar : PubMed/NCBI | |
Lee HC and Wei YH: Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. Int J Biochem Cell Biol. 37:822–834. 2005. View Article : Google Scholar : PubMed/NCBI | |
Yeung KY, Dickinson A, Donoghue JF, Polekhina G, White SJ, Grammatopoulos DK, McKenzie M, Johns TG and St John JC: The identification of mitochondrial DNA variants in glioblastoma multiforme. Acta Neuropathol Commun. 2:12014. View Article : Google Scholar : PubMed/NCBI | |
Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, et al: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat Genet. 52:342–352. 2020. View Article : Google Scholar : PubMed/NCBI | |
Jiang H, Zhao H, Xu H, Hu L, Wang W, Wei Y, Wang Y, Peng X and Zhou F: Peripheral blood mitochondrial DNA content, A10398G polymorphism, and risk of breast cancer in a Han Chinese population. Cancer Sci. 105:639–645. 2014. View Article : Google Scholar : PubMed/NCBI | |
Shen J, Platek M, Mahasneh A, Ambrosone CB and Zhao H: Mitochondrial copy number and risk of breast cancer: A pilot study. Mitochondrion. 10:62–68. 2010. View Article : Google Scholar : PubMed/NCBI | |
Fazzini F, Schöpf B, Blatzer M, Coassin S, Hicks AA, Kronenberg F and Fendt L: Plasmid-normalized quantification of relative mitochondrial DNA copy number. Sci Rep. 8:153472018. View Article : Google Scholar : PubMed/NCBI | |
Castellani CA, Longchamps RJ, Sumpter JA, Newcomb CE, Lane JA, Grove ML, Bressler J, Brody JA, Floyd JS, Bartz TM, et al: Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs. Genome Med. 12:842020. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Lv H, Ji P, Zhu X, Yuan H, Jin G, Dai J, Hu Z, Su Y and Ma H: Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population. Cancer Med. 7:2776–2782. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shen J, Wan J, Song R and Zhao H: Peripheral blood mitochondrial DNA copy number, length heteroplasmy and breast cancer risk: A replication study. Carcinogenesis. 36:1307–1313. 2015. View Article : Google Scholar : PubMed/NCBI | |
Xia P, An HX, Dang CX, Radpour R, Kohler C, Fokas E, Engenhart-Cabillic R, Holzgreve W and Zhong XY: Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer. BMC Cancer. 9:4542009. View Article : Google Scholar : PubMed/NCBI | |
Jung SJ, Cho JH, Park WJ, Heo YR and Lee JH: Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer. Oncol Lett. 14:925–929. 2017. View Article : Google Scholar : PubMed/NCBI | |
O'Hara R, Tedone E, Ludlow A, Huang E, Arosio B, Mari D and Shay JW: Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution. Genome Res. 29:1878–1888. 2019. View Article : Google Scholar : PubMed/NCBI | |
Memon AA, Zöller B, Hedelius A, Wang X, Stenman E, Sundquist J and Sundquist K: Quantification of mitochondrial DNA copy number in suspected cancer patients by a well optimized ddPCR method. Biomol Detect Quantif. 13:32–39. 2017. View Article : Google Scholar : PubMed/NCBI | |
Filograna R, Mennuni M, Alsina D and Larsson NG: Mitochondrial DNA copy number in human disease: The more the better? FEBS Lett. 595:976–1002. 2021. View Article : Google Scholar : PubMed/NCBI | |
Longchamps RJ, Castellani CA, Yang SY, Newcomb CE, Sumpter JA, Lane J, Grove ML, Guallar E, Pankratz N, Taylor KD, et al: Evaluation of mitochondrial DNA copy number estimation techniques. PLoS One. 15:e02281662020. View Article : Google Scholar : PubMed/NCBI | |
Zhou K, Mo Q, Guo S, Liu Y, Yin C, Ji X, Guo X and Xing J: A novel next-generation sequencing-based approach for concurrent detection of mitochondrial DNA copy number and mutation. J Mol Diagn. 22:1408–1418. 2020. View Article : Google Scholar : PubMed/NCBI | |
Picard M: Blood mitochondrial DNA copy number: What are we counting? Mitochondrion. 60:1–11. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ware SA, Desai N, Lopez M, Leach D, Zhang Y, Giordano L, Nouraie M, Picard M and Kaufman BA: An automated, high-throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma. J Biol Chem. 295:15677–15691. 2020. View Article : Google Scholar : PubMed/NCBI | |
Guo W, Jiang L, Bhasin S, Khan SM and Swerdlow RH: DNA extraction procedures meaningfully influence qPCR-based mtDNA copy number determination. Mitochondrion. 9:261–265. 2009. View Article : Google Scholar : PubMed/NCBI | |
Tseng LM, Yin PH, Chi CW, Hsu CY, Wu CW, Lee LM, Wei YH and Lee HC: Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer. Genes Chromosom Cancer. 45:629–638. 2006. View Article : Google Scholar : PubMed/NCBI | |
Fan AX, Radpour R, Haghighi MM, Kohler C, Xia P, Hahn S, Holzgreve W and Zhong XY: Mitochondrial DNA content in paired normal and cancerous breast tissue samples from patients with breast cancer. J Cancer Res Clin Oncol. 135:983–989. 2009. View Article : Google Scholar : PubMed/NCBI | |
Nacheva E, Mokretar K, Soenmez A, Pittman AM, Grace C, Valli R, Ejaz A, Vattathil S, Maserati E, Houlden H, et al: DNA isolation protocol effects on nuclear DNA analysis by microarrays, droplet digital PCR, and whole genome sequencing, and on mitochondrial DNA copy number estimation. PLoS One. 12:e01804672017. View Article : Google Scholar : PubMed/NCBI | |
Hsu CW, Yin PH, Lee HC, Chi CW and Tseng LM: Mitochondrial DNA content as a potential marker to predict response to anthracycline in breast cancer patients. Breast J. 16:264–270. 2010. View Article : Google Scholar : PubMed/NCBI | |
Domínguez-de-la-Cruz E, Muñoz ML, Pérez-Muñoz A, García-Hernández N, Moctezuma-Meza C and Hinojosa-Cruz JC: Reduced mitochondrial DNA copy number is associated with the haplogroup, and some clinical features of breast cancer in Mexican patients. Gene. 761:1450472020. View Article : Google Scholar : PubMed/NCBI | |
Lemnrau A, Brook MN, Fletcher O, Coulson P, Tomczyk K, Jones M, Ashworth A, Swerdlow A, Orr N and Garcia-Closas M: Mitochondrial DNA copy number in peripheral blood cells and risk of developing breast cancer. Cancer Res. 75:2844–2850. 2015. View Article : Google Scholar : PubMed/NCBI | |
Thyagarajan B, Wang R, Nelson H, Barcelo H, Koh W and Yuan M: Mitochondrial DNA copy number is associated with breast cancer risk. PLoS One. 8:e659682013. View Article : Google Scholar : PubMed/NCBI | |
Feng S, Xiong L, Ji Z, Cheng W and Yang H: Correlation between increased copy number of mitochondrial DNA and clinicopathological stage in colorectal cancer. Oncol Lett. 2:899–903. 2011.PubMed/NCBI | |
Chen T, He J, Shen L, Fang H, Nie H, Jin T, Wei X, Xin Y, Jiang Y, Li H, et al: The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer. BMC Med Genet. 12:82011. View Article : Google Scholar : PubMed/NCBI | |
Qu F, Liu X, Zhou F, Yang H, Bao G, He X and Xing J: Association between mitochondrial DNA content in leukocytes and colorectal cancer risk: A case-control analysis. Cancer. 117:3148–3155. 2011. View Article : Google Scholar : PubMed/NCBI | |
Thyagarajan B, Wang R, Barcelo H, Koh WP and Yuan JM: Mitochondrial copy number is associated with colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 21:1574–1581. 2012. View Article : Google Scholar : PubMed/NCBI | |
Tong H, Zhang L, Gao J, Wen S, Zhou H and Feng S: Methylation of mitochondrial DNA displacement loop region regulates mitochondrial copy number in colorectal cancer. Mol Med Rep. 16:5347–5353. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang K, Li X, Forman MR, Monahan PO, Graham BH, Joshi A, Song M, Hang D, Ogino S, Giovannucci EL, et al: Pre-diagnostic leukocyte mitochondrial DNA copy number and colorectal cancer risk. Carcinogenesis. 40:1462–1468. 2019. View Article : Google Scholar : PubMed/NCBI | |
Mohideen AM, Dicks E, Parfrey P, Green R and Savas S: Mitochondrial DNA polymorphisms, its copy number change and outcome in colorectal cancer. BMC Res Notes. 8:2722015. View Article : Google Scholar : PubMed/NCBI | |
Cui HH, Huang P, Wang ZJ, Zhang Y, Zhang Z, Xu W, Wang X, Han Y and Guo X: Association of decreased mitochondrial DNA content with the progression of colorectal cancer. BMC Cancer. 13:1102013. View Article : Google Scholar : PubMed/NCBI | |
Huang B, Gao YT, Shu XO, Wen W, Yang G, Li G, Courtney R, Ji BT, Li HL, Purdue MP, et al: Association of leukocyte mitochondrial DNA copy number with colorectal cancer risk: Results from the Shanghai women's health study. Cancer Epidemiol Biomarkers Prev. 23:2357–2365. 2014. View Article : Google Scholar : PubMed/NCBI | |
van Osch FH, Voets AM, Schouten LJ, Gottschalk RW, Simons CC, van Engeland M, Lentjes MH, van den Brandt PA, Smeets HJ and Weijenberg MP: Mitochondrial DNA copy number in colorectal cancer: Between tissue comparisons, clinicopathological characteristics and survival. Carcinogenesis. 36:1502–1510. 2015.PubMed/NCBI | |
Marucci G, Maresca A, Caporali L, Farnedi A, Betts CM, Morandi L, de Biase D, Cerasoli S, Foschini MP, Bonora E, et al: Oncocytic glioblastoma: A glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number. Hum Pathol. 44:1867–1876. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Li D, Qu F, Chen Y, Li G, Jiang H, Huang X, Yang H and Xing J: Association of leukocyte mitochondrial DNA content with glioma risk: Evidence from a Chinese case-control study. BMC Cancer. 14:6802014. View Article : Google Scholar : PubMed/NCBI | |
Shen J, Song R, Lu Z and Zhao H: Mitochondrial DNA copy number in whole blood and glioma risk: A case control study. Mol Carcinog. 55:2089–2094. 2016. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Zhang J, Huang X, Zhang J, Zhou X, Hu J, Li G, He S and Xing J: High leukocyte mitochondrial DNA content contributes to poor prognosis in glioma patients through its immunosuppressive effect. Br J Cancer. 113:99–106. 2015. View Article : Google Scholar : PubMed/NCBI | |
Dardaud LM, Bris C, Desquiret-Dumas V, Boisselier B, Tabouret E, Mokhtari K, Figarella-Branger D, Rousseau A and Procaccio V: High mitochondrial DNA copy number is associated with longer survival in young patients with glioblastoma. Neuro Oncol. 21:1084–1085. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Qu Y, Gao K, Yang Q, Shi B, Hou P and Ji M: High copy number of mitochondrial DNA (mtDNA) predicts good prognosis in glioma patients. Am J Cancer Res. 5:1207–16. 2015.PubMed/NCBI | |
Oliva CR, Nozell SE, Diers A, McClugage SG III, Sarkaria JN, Markert JM, Darley-Usmar VM, Bailey SM, Gillespie GY, Landar A and Griguer CE: Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. J Biol Chem. 285:39759–39767. 2010. View Article : Google Scholar : PubMed/NCBI | |
Shen H, Yu M, Tsoli M, Chang C, Joshi S, Liu J, Ryall S, Chornenkyy Y, Siddaway R, Hawkins C and Ziegler DS: Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas. Neuro Oncol. 22:139–151. 2020. View Article : Google Scholar : PubMed/NCBI | |
Sravya P, Nimbalkar VP, Kanuri NN, Sugur H, Verma BK, Kundu P, Rao S, Uday Krishna AS, Somanna S, Kondaiah P, et al: Low mitochondrial DNA copy number is associated with poor prognosis and treatment resistance in glioblastoma. Mitochondrion. 55:154–163. 2020. View Article : Google Scholar : PubMed/NCBI | |
Li F, Wang X, Han C and Lin J: Decreased mtDNA copy number of gastric cancer: A new tumor marker? Chin J Clin Oncol. 1:250–255. 2004. View Article : Google Scholar | |
Wu CW, Yin PH, Hung WY, Li AF, Li SH, Chi CW, Wei YH and Lee HC: Mitochondria DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chromosom Cancer. 44:19–28. 2005. View Article : Google Scholar : PubMed/NCBI | |
Zhang G, Qu Y, Dang S, Yang Q, Shi B and Hou P: Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol. 8:1732013. View Article : Google Scholar : PubMed/NCBI | |
Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, et al: Mitochondrial DNA copy number and risk of gastric cancer: A report from the Shanghai women's health study. Cancer Epidemiol Biomarkers Prev. 20:1944–1949. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wen SL, Zhang F and Feng S: Decreased copy number of mitochondrial DNA: A potential diagnostic criterion for gastric cancer. Oncol Lett. 6:1098–1102. 2013. View Article : Google Scholar : PubMed/NCBI | |
Mizumachi T, Muskhelishvili L, Naito A, Furusawa J, Fan CY, Siegel ER, Kadlubar FF, Kumar U and Higuchi M: Increased distributional variance of mitochondrial DNA content associated with prostate cancer cells as compared with normal prostate cells. Prostate. 68:408–417. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zhou W, Zhu M, Gui M, Huang L, Long Z, Wang L, Chen H, Yin Y, Jiang X, Dai Y, et al: Peripheral blood mitochondrial DNA copy number is associated with prostate cancer risk and tumor burden. PLoS One. 9:e1094702014. View Article : Google Scholar : PubMed/NCBI | |
Abhishek A, Singh V, Sinha RJ, Ansari NG, Siddiqe MK, Verma M and Kumar M: To study the relationship between cadmium, zinc and mtDNA copy number in North Indian patients suffering from prostate cancer: A case control study. Afr J Urol. 23:126–132. 2017. View Article : Google Scholar | |
Moore A, Lan Q, Hofmann JN, Liu CS, Cheng WL, Lin TT and Berndt SI: A prospective study of mitochondrial DNA copy number and the risk of prostate cancer. Cancer Causes Control. 28:529–538. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tu H, Gu J, Meng QH, Kim J, Davis JW, He Y, Wagar EA, Thompson TC, Logothetis CJ and Wu X: Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer. Oncotarget. 6:41988–41996. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kalsbeek AM, Chan EK, Grogan J, Petersen DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG, Kench JG, et al: Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer. Prostate. 78:25–31. 2018. View Article : Google Scholar : PubMed/NCBI | |
Xu J, Chang WS, Tsai CW, Bau DT, Davis JW, Thompson TC, Logothetis CJ and Gu J: Mitochondrial DNA copy number in peripheral blood leukocytes is associated with biochemical recurrence in prostate cancer patients in African Americans. Carcinogenesis. 41:267–273. 2020. View Article : Google Scholar : PubMed/NCBI | |
Tan DJ, Chang J, Liu LL, Bai RK, Wang YF, Yeh KT and Wong LJC: Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer. BMC Cancer. 6:932006. View Article : Google Scholar : PubMed/NCBI | |
Liu Z, Zhao Z and Zhao Q: Change in the mitochondrial DNA copy number and its significance in esophageal squamous cell carcinoma. Chin J Clin Oncol. 34:7–9. 2007. | |
Lin CS, Chang SC, Wang LS, Chou TY, Hsu WH, Wu YC and Wei YH: The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas. J Thorac Cardiovasc Surg. 139:189–197.e4. 2010. View Article : Google Scholar : PubMed/NCBI | |
Li H, Tian Z, Zhang Y, Yang Q, Shi B, Hou P and Ji M: Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Lett. 15:1014–1020. 2018.PubMed/NCBI | |
Masuike Y, Tanaka K, Makino T, Yamasaki M, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Mori M and Doki Y: Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis. PLoS One. 13:e01931592018. View Article : Google Scholar : PubMed/NCBI | |
Xu E, Sun W, Gu J, Chow WH, Ajani JA and Wu X: Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma. Carcinogenesis. 34:2521–2524. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim MM, Clinger JD, Masayesva BG, Ha PK, Zahurak ML, Westra WH and Califano JA: Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res. 10:8512–8515. 2004. View Article : Google Scholar : PubMed/NCBI | |
Jiang WW, Rosenbaum E, Mambo E, Zahurak M, Masayesva B, Carvalho AL, Zhou S, Westra WH, Alberg AJ, Sidransky D, et al: Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Cancer Ther Clin. 12:1564–1569. 2006. View Article : Google Scholar : PubMed/NCBI | |
Cheau-Feng Lin F, Jeng YC, Huang TY, Chi CS, Chou MC and Chin-Shaw Tsai S: Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancer. Biomarkers. 19:269–274. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kumar M, Srivastava S, Singh SA, Das AK, Das GC, Dhar B, Ghosh SK and Mondal R: Cell-free mitochondrial DNA copy number variation in head and neck squamous cell carcinoma: A study of non-invasive biomarker from Northeast India. Tumor Biol. Oct 26–2017.(Epub ahead of print). View Article : Google Scholar | |
Chen J, Zhang L, Yu X, Zhou H, Luo Y, Wang W and Wang L: Clinical application of plasma mitochondrial DNA content in patients with lung cancer. Oncol Lett. 16:7074–7081. 2018.PubMed/NCBI | |
Bonner MR, Shen M, Liu CS, DiVita M, He X and Lan Q: Mitochondrial DNA content and lung cancer risk in Xuan Wei, China. Lung Cancer. 63:331–334. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hosgood HD III, Liu CS, Rothman N, Weinstein SJ, Bonner MR, Shen M, Lim U, Virtamo J, Cheng WL, Albanes D and Lan Q: Mitochondrial DNA copy number and lung cancer risk in a prospective cohort study. Carcinogenesis. 31:847–849. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kim C, Bassig BA, Seow WJ, Hu W, Purdue MP, Shu XO, Huang WY, Liu CS, Cheng WL, Lin TT, et al: Pooled analysis of mitochondrial DNA copy number and lung cancer risk in three prospective studies. Cancer Epidemiol Biomarkers Prev. 23:2977–2980. 2014. View Article : Google Scholar : PubMed/NCBI | |
Meierhofer D, Mayr JA, Foetschl U, Berger A, Fink K, Schmeller N, Hacker GW, Hauser-Kronberger C, Kofler B and Sperl W: Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis. 25:1005–1010. 2004. View Article : Google Scholar : PubMed/NCBI | |
Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, et al: Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst. 100:1104–1112. 2008. View Article : Google Scholar : PubMed/NCBI | |
Purdue MP, Hofmann JN, Colt JS, Hoxha M, Ruterbusch JJ, Davis FG, Rothman N, Wacholder S, Schwartz KL, Baccarelli A and Chow WH: A case-control study of peripheral blood mitochondrial DNA copy number and risk of renal cell carcinoma. PLoS One. 7:e431492012. View Article : Google Scholar : PubMed/NCBI | |
Lin CS, Lee HT, Lee MH, Pan SC, Ke CY, Chiu AW and Wei YH: Role of mitochondrial DNA copy number alteration in human renal cell carcinoma. Int J Mol Sci. 17:8142016. View Article : Google Scholar : PubMed/NCBI | |
Hofmann JN, Hosgood HD III, Liu CS, Chow WH, Shuch B, Cheng WL, Lin TT, Moore LE, Lan Q, Rothman N and Purdue MP: A nested case-control study of leukocyte mitochondrial DNA copy number and renal cell carcinoma in the prostate, lung, colorectal and ovarian cancer screening trial. Carcinogenesis. 35:1028–1031. 2014. View Article : Google Scholar : PubMed/NCBI | |
Elsayed ET, Hashad MM and Elgohary IE: Mitochondrial DNA copy number variation as a potential predictor of renal cell carcinoma. Int J Biol Markers. 32:e313–e318. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Liu VW, Xue WC, Tsang PC, Cheung AN and Ngan HY: The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: A quantitative study using laser-captured microdissected tissues. Gynecol Oncol. 98:104–110. 2005. View Article : Google Scholar : PubMed/NCBI | |
Cormio A, Guerra F, Cormio G, Pesce V, Fracasso F, Loizzi V, Resta L, Putignano G, Cantatore P, Selvaggi LE and Gadaleta MN: Mitochondrial DNA content and mass increase in progression from normal to hyperplastic to cancer endometrium. BMC Res Notes. 5:2792012. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Zhang L, Ho SS, Wu X and Gu J: Lower mitochondrial DNA copy number in peripheral blood leukocytes increases the risk of endometrial cancer. Mol Carcinog. 55:1111–1117. 2016. View Article : Google Scholar : PubMed/NCBI | |
Mondal R, Ghosh SK, Choudhury JH, Seram A, Sinha K, Hussain M, Laskar RS, Rabha B, Dey P, Ganguli S, et al: Mitochondrial DNA copy number and risk of oral cancer: A report from Northeast India. PLoS One. 8:e577712013. View Article : Google Scholar : PubMed/NCBI | |
He Y, Gong Y, Gu J, Lee JJ, Lippman SM and Wu X: Increased leukocyte mitochondrial DNA copy number is associated with oral premalignant lesions: an epidemiology study. Carcinogenesis. 35:1760–1764. 2014. View Article : Google Scholar : PubMed/NCBI | |
Takeda D, Hasegawa T, Ueha T, Sakakibara A, Kawamoto T, Minamikawa T, Sakai Y and Komori T: Decreased mitochondrial copy numbers in oral squamous cell carcinoma. Head Neck. 36:1170–1175. 2016. View Article : Google Scholar : PubMed/NCBI | |
Lynch SM, Weinstein SJ, Virtamo J, Lan Q, Liu CS, Cheng WL, Rothman N, Albanes D and Stolzenberg-Solomon RZ: Mitochondrial DNA copy number and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention study. Cancer Prev Res (Phila). 4:1912–1919. 2011. View Article : Google Scholar : PubMed/NCBI | |
Tuchalska-Czuroń J, Lenart J, Augustyniak J and Durlik M: Is mitochondrial DNA copy number a good prognostic marker in resectable pancreatic cancer? Pancreatology. 19:73–79. 2019. View Article : Google Scholar : PubMed/NCBI | |
Gentiluomo M, Katzke VA, Kaaks R, Tjønneland A, Severi G, Perduca V, Boutron-Ruault MC, Weiderpass E, Ferrari P, Johnson T, et al: Mitochondrial DNA copy-number variation and pancreatic cancer risk in the prospective EPIC cohort. Cancer Epidemiol Biomarkers Prev. 29:681–686. 2020. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Liu VW, Xue WC, Cheung AN and Ngan HY: Association of decreased mitochondrial DNA content with ovarian cancer progression. Br J Cancer. 95:1087–1091. 2006. View Article : Google Scholar : PubMed/NCBI | |
Keserű JS, Soltész B, Lukács J, Márton É, Szilágyi-Bónizs M, Penyige A, Póka R and Nagy B: Detection of cell-free, exosomal and whole blood mitochondrial DNA copy number in plasma or whole blood of patients with serous epithelial ovarian can. J Biotechnol. 298:76–81. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hyland PL, Pfeiffer RM, Rotunno M, Hofmann JN, Liu CS, Cheng WL, Yuenger J, Lan Q, Tucker MA, Goldstein AM and Yang XR: Constitutive mitochondrial DNA copy number in peripheral blood of melanoma families with and without CDKN2A mutations. J Carcinog Mutagen. 2014 (Suppl 4):S0062014. | |
Shen J, Gopalakrishnan V, Lee JE, Fang S and Zhao H: Mitochondrial DNA copy number in peripheral blood and melanoma risk. PLoS One. 10:e01316492015. View Article : Google Scholar : PubMed/NCBI | |
Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M, Shi B and Hou P: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients. Diagn Pathol. 9:282014. View Article : Google Scholar : PubMed/NCBI | |
Guo W, Yang D, Xu H, Zhang Y, Huang J, Yang Z, Chen X and Huang Z: Mutations in the D-loop region and increased copy number of mitochondrial DNA in human laryngeal squamous cell carcinoma. Mol Biol Rep. 40:13–20. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hurtado-Roca Y, Ledesma M, Gonzalez-Lazaro M, Moreno-Loshuertos R, Fernandez-Silva P, Enriquez JA and Laclaustra M: Adjusting MtDNA quantification in whole blood for peripheral blood platelet and leukocyte counts. PLoS One. 11:e01637702016. View Article : Google Scholar : PubMed/NCBI | |
Malik AN and Czajka A: Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion. 13:481–492. 2013. View Article : Google Scholar : PubMed/NCBI | |
Anderson C, Fry RC, Hartwell H, Kleeberger C, Sandler DP and Nichols HB: Measurement of mitochondrial DNA copy number in dried blood spots: A pilot study. Mitochondrion. 56:35–39. 2021. View Article : Google Scholar : PubMed/NCBI | |
Parr RL, Dakubo GD, Thayer RE, McKenney K and Birch-Machin MA: Mitochondrial DNA as a potential tool for early cancer detection. Hum Genomics. 2:252–257. 2006. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Zhou K, Guo S, Wang Y, Ji X, Yuan Q, Su L, Guo X, Gu X and Xing J: NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients. Mol Ther Nucleic Acids. 23:657–666. 2021. View Article : Google Scholar : PubMed/NCBI |