Open Access

Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)

  • Authors:
    • Zizi Zhou
    • Wenxiang Chai
    • Yi Liu
    • Meng Zhou
    • Xiaoming Zhang
  • View Affiliations

  • Published online on: June 24, 2022     https://doi.org/10.3892/ijmm.2022.5166
  • Article Number: 110
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Connexins (Cxs) play key roles in cellular communication. By facilitating metabolite exchange or interfering with distinct signaling pathways, Cxs affect cell homeostasis, proliferation, and differentiation. Variations in the activity and expression of Cxs have been linked to numerous clinical conditions including carcinomas, cardiac disorders, and wound healing. Recent discoveries on the association between Cxs and angiogenesis have sparked interest in Cx‑mediated angiogenesis due to its essential functions in tissue formation, wound repair, tumor growth, and metastasis. It is now widely recognized that understanding the association between Cxs and angiogenesis may aid in the development of new targeted therapies for angiogenic diseases. The aim of the present review was to provide a comprehensive overview of Cxs and Cx‑mediated angiogenesis, with a focus on therapeutic implications.
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August-2022
Volume 50 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Z, Chai W, Liu Y, Zhou M and Zhang X: Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). Int J Mol Med 50: 110, 2022.
APA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., & Zhang, X. (2022). Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review). International Journal of Molecular Medicine, 50, 110. https://doi.org/10.3892/ijmm.2022.5166
MLA
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50.2 (2022): 110.
Chicago
Zhou, Z., Chai, W., Liu, Y., Zhou, M., Zhang, X."Connexins and angiogenesis: Functional aspects, pathogenesis, and emerging therapies (Review)". International Journal of Molecular Medicine 50, no. 2 (2022): 110. https://doi.org/10.3892/ijmm.2022.5166