The metabolic and molecular mechanisms of α‑mangostin in cardiometabolic disorders (Review)
- Authors:
- Oliver Dean John
- Annals Tatenda Mushunje
- Noumie Surugau
- Rhanye Mac Guad
-
Affiliations: Faculty of Science and Natural Resources, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia, Faculty of Science, Asia‑Pacific International University, Muak Lek, Saraburi 18180, Thailand, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia - Published online on: July 27, 2022 https://doi.org/10.3892/ijmm.2022.5176
- Article Number: 120
-
Copyright: © John et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr and Lenfant C; American Heart Association: National Heart, Lung, and Blood Institute: Definition of metabolic syndrome: Report of the national heart, lung, and blood institute/American heart association conference on scientific issues related to definition. Circulation. 109:433–438. 2004. View Article : Google Scholar : PubMed/NCBI | |
Pite H, Aguiar L, Morello J, Monteiro EC, Alves AC, Bourbon M and Morais-Almeida M: Metabolic dysfunction and asthma: Current perspectives. J Asthma Allergy. 13:237–247. 2020. View Article : Google Scholar : PubMed/NCBI | |
O'Neill S and O'Driscoll L: Metabolic syndrome: A closer look at the growing epidemic and its associated pathologies. Obes Rev. 16:1–12. 2015. View Article : Google Scholar | |
ASMBS Clinical Issues Committee: Bariatric surgery in class I obesity (body mass index 30-35 kg/m2). Surg Obes Relat Dis. 9:e1–e10. 2013. View Article : Google Scholar | |
Hill JO, Wyatt HR and Peters JC: Energy balance and obesity. Circulation. 126:126–132. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zatterale F, Longo M, Naderi J, Raciti GA, Desiderio A, Miele C and Beguinot F: Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Front Physiol. 10:16072020. View Article : Google Scholar : PubMed/NCBI | |
Zafar U, Khaliq S, Ahmad HU, Manzoor S and Lone KP: Metabolic syndrome: An update on diagnostic criteria, pathogenesis, and genetic links. Hormones (Athens). 17:299–313. 2018. View Article : Google Scholar | |
Halpern A, Pepe RB, Monegaglia AP, Beyruti M, de Melo ME and Mancini MC: Efficacy and tolerability of the association of sibutramine and orlistat for six months in overweight and obese patients. J Obes. 2010:6025372010. View Article : Google Scholar : PubMed/NCBI | |
Francini-Pesenti F, Spinella P and Calò LA: Potential role of phytochemicals in metabolic syndrome prevention and therapy. Diabetes Metab Syndr Obes. 12:1987–2002. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu QY, Wang YT and Lin LG: New insights into the anti-obesity activity of xanthones from Garcinia mangostana. Food Funct. 6:383–393. 2015. View Article : Google Scholar | |
John OD, Brown L and Panchal SK: Garcinia fruits: Their potential to combat metabolic syndrome. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery. Ullah MF and Ahmad A: John Wiley & Sons, Inc; Hoboken, NJ: pp. 39–80. 2019 | |
John OD, Mouatt P, Panchal SK and Brown L: Rind from purple mangosteen (Garcinia mangostana) attenuates diet-induced physiological and metabolic changes in obese rats. Nutrients. 13:3192021. View Article : Google Scholar : | |
Ee GC, Daud S, Taufiq-Yap YH, Ismail NH and Rahmani M: Xanthones from Garcinia mangostana (Guttiferae). Nat Prod Res. 20:1067–1073. 2006. View Article : Google Scholar : PubMed/NCBI | |
Khamthong N and Hutadilok-Towatana N: Phytoconstituents and biological activities of Garcinia dulcis (Clusiaceae): A review. Nat Prod Commun. 12:453–460. 2017.PubMed/NCBI | |
Ngoupayo J, Tabopda TK and Ali MS: Antimicrobial and immunomodulatory properties of prenylated xanthones from twigs of Garcinia staudtii. Bioorg Med Chem. 17:5688–5695. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kijjoa A, Gonzalez MJ, Pinto MM, Nascimento MS, Campos N, Mondranondra IO, Silva AM, Eaton G and Herz W: Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis. Planta Med. 74:864–866. 2008. View Article : Google Scholar : PubMed/NCBI | |
Fatma Sri W, Daud Ahmad Israf A, Nordin Hj L and Dachriyanus: Anti-inflammatory activity of isolated compounds from the stem bark of Garcinia cowa Roxb. Pharmacogn J. 9:55–57. 2017. | |
Phuwapraisirisan P, Udomchotphruet S, Surapinit S and Tip-Pyang S: Antioxidant xanthones from Cratoxylum cochinchinense. Nat Prod Res. 20:1332–1337. 2006. View Article : Google Scholar | |
Ibrahim MY, Hashim NM, Mohan S, Abdulla MA, Abdelwahab SI, Arbab IA, Yahayu M, Ali LZ and Ishag OE: α-Mangostin from Cratoxylum arborescens: An in vitro and in vivo toxicological evaluation. Arab J Chem. 8:129–137. 2015. View Article : Google Scholar | |
Thaweboon S, Thaweboon B, Nisalak P and Kaypetch R: Inhibitory effect of Cratoxylum formosum gum on candida glabrata and its α-mangostin content. MATEC Web Conf. 65:030042016. View Article : Google Scholar | |
Lenta BN, Kamdem LM, Ngouela S, Tantangmo F, Devkota KP, Boyom FF, Rosenthal PJ and Tsamo E: Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea. Planta Med. 77:377–379. 2011. View Article : Google Scholar | |
Ghasemzadeh A, Jaafar HZE, Baghdadi A and Tayebi-Meigooni A: Alpha-mangostin-rich extracts from mangosteen pericarp: Optimization of green extraction protocol and evaluation of biological activity. Molecules. 23:18522018. View Article : Google Scholar : | |
Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M and Pérez-Rojas JM: Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 46:3227–3239. 2008. View Article : Google Scholar : PubMed/NCBI | |
Choi YH, Bae JK, Chae HS, Kim YM, Sreymom Y, Han L, Jang HY and Chin YW: α-Mangostin regulates hepatic steatosis and obesity through SirT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice. J Agric Food Chem. 63:8399–8406. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kim HM, Kim YM, Huh JH, Lee ES, Kwon MH, Lee BR, Ko HJ and Chung CH: α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2. PLoS One. 12:e01792042017. View Article : Google Scholar | |
Vien LC, Chinnappan S and Mogana R: Antioxidant activity of Garcinia mangostana L and alpha mangostin: A review. Res J Pharm Technol. 14:4466–4470. 2021. View Article : Google Scholar | |
Pan T, Chen R, Wu D, Cai N, Shi X, Li B and Pan J: Alpha-mangostin suppresses interleukin-1β-induced apoptosis in rat chondrocytes by inhibiting the NF-κB signaling pathway and delays the progression of osteoarthritis in a rat model. Int Immunopharmacol. 52:156–162. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chae HS, Oh SR, Lee HK, Joo SH and Chin YW: Mangosteen xanthones, α-and γ-mangostins, inhibit allergic mediators in bone marrow-derived mast cell. Food Chem. 134:397–400. 2012. View Article : Google Scholar | |
Li P, Tian W and Ma X: Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. Mol Cancer. 13:1382014. View Article : Google Scholar : PubMed/NCBI | |
Yang A, Liu C, Wu J, Kou X and Shen R: A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease. Eur J Pharmacol. 897:1739502021. View Article : Google Scholar | |
Rodniem S, Tiyao V, Nilbu-Nga C, Poonkhum R, Pongmayteegul S and Pradidarcheep W: Protective effect of alpha-mangostin on thioacetamide-induced liver fibrosis in rats as revealed by morpho-functional analysis. Histol Histopathol. 34:419–430. 2019. | |
Sampath PD and Vijayaragavan K: Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against beta-adrenergic cathecola-mine-induced myocardial toxicity and anomalous cardiac TNF-α and COX-2 expressions in rats. Exp Toxicol Pathol. 60:357–364. 2008. View Article : Google Scholar : PubMed/NCBI | |
Sivaranjani M, Prakash M, Gowrishankar S, Rathna J, Pandian SK and Ravi AV: In vitro activity of alpha-mangostin in killing and eradicating Staphylococcus epidermidis RP62A biofilms. Appl Microbiol Biotechnol. 101:3349–3359. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kaomongkolgit R, Jamdee K and Chaisomboon N: Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 51:401–406. 2009. View Article : Google Scholar : PubMed/NCBI | |
Zhang KJ, Gu QL, Yang K, Ming XJ and Wang JX: Anticarcinogenic effects of α-mangostin: A review. Planta Med. 83:188–202. 2017. | |
Chen G, Li Y, Wang W and Deng L: Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: A review. Expert Opin Ther Pat. 28:415–427. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ibrahim MY, Hashim NM, Mariod AA, Mohan S, Abdulla MA, Abdelwahab SI and Arbab IA: α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties. Arab J Chem. 9:317–329. 2016. View Article : Google Scholar | |
Jindarat S: Xanthones from mangosteen (Garcinia mangostana): Multi-targeting pharmacological properties. J Med Assoc Thai. 97(Suppl 2): S196–S201. 2014.PubMed/NCBI | |
Tousian Shandiz H, Razavi BM and Hosseinzadeh H: Review of Garcinia mangostana and its xanthones in metabolic syndrome and related complications. Phytother Res. 31:1173–1182. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang MH, Zhang KJ, Gu QL, Bi XL and Wang JX: Pharmacology of mangostins and their derivatives: A comprehensive review. Chin J Nat Med. 15:81–93. 2017.PubMed/NCBI | |
Abuzaid AS, Sukandar E, Kurniati NF and Adnyana IK: Preventive effect on obesity of mangosteen (Garcinia mangostana L.) pericarp ethanolic extract by reduction of fatty acid synthase level in monosodium glutamate and high-calorie diet-induced male wistar rats. Asian J Pharm Clin Res. 9:257–260. 2016. | |
Li D, Liu Q, Lu X, Li Z, Wang C, Leung CH, Wang Y, Peng C and Lin L: α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice. Aging (Albany NY). 11:11084–11110. 2019. View Article : Google Scholar | |
Tsai SY, Chung PC, Owaga EE, Tsai IJ, Wang PY, Tsai JI, Yeh TS and Hsieh RH: Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis. Nutr Metab (Lond). 13:882016. View Article : Google Scholar | |
Muhamad Adyab NS, Rahmat A, Abdul Kadir NAA, Jaafar H, Shukri R and Ramli NS: Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats. BMC Complement Altern Med. 19:3442019. View Article : Google Scholar : PubMed/NCBI | |
Chae HS, Kim YM, Bae JK, Sorchhann S, Yim S, Han L, Paik JH, Choi YH and Chin YW: Mangosteen extract attenuates the metabolic disorders of high-fat-fed mice by activating AMPK. J Med Food. 19:148–154. 2016. View Article : Google Scholar | |
Mohamed SM, Mohammed DS, Abd Elhaliem NG, Elbadry MI and Abu-Dief EE: Mangosteen can improve steatohepatitis through modulating inflammatory and autophagy/apoptosis cell injury: An animal model study. Cytol Genet. 55:480–490. 2021. View Article : Google Scholar | |
Klop B, Elte JWF and Cabezas MC: Dyslipidemia in obesity: Mechanisms and potential targets. Nutrients. 5:1218–1240. 2013. View Article : Google Scholar : PubMed/NCBI | |
Taher M, Mohamed Amiroudine MZ, Tengku Zakaria TM, Susanti D, Ichwan SJ, Kaderi MA, Ahmed QU and Zakaria ZA: α-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPARγ, GLUT4, and leptin expressions. Evid Based Complementary Altern Med. 2015:7402382015. View Article : Google Scholar | |
Chae HS, Kim EY, Han L, Kim NR, Lam B, Paik JH, Yoon KD, Choi YH and Chin YW: Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L.(Guttiferae). Eur J Lipid Sci Technol. 118:1416–1421. 2016. View Article : Google Scholar | |
Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P and Auwerx J: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 458:1056–1060. 2009. View Article : Google Scholar : PubMed/NCBI | |
Fu Z, R Gilbert E and Liu D: Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev. 9:25–53. 2013. View Article : Google Scholar | |
Lee D, Kim YM, Jung K, Chin YW and Kang KS: Alpha-mangostin improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage. Int J Mol Sci. 19:14842018. View Article : Google Scholar : | |
Langlais P, Yi Z, Finlayson J, Luo M, Mapes R, De Filippis E, Meyer C, Plummer E, Tongchinsub P, Mattern M and Mandarino LJ: Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia. 54:2878–2889. 2011. View Article : Google Scholar : PubMed/NCBI | |
De Meyts P: The insulin receptor and its signal transduction network. Endotext [Internet]. MDText.com, Inc. South Dartmouth, MA: 2016 | |
Taniguchi CM, Emanuelli B and Kahn CR: Critical nodes in signalling pathways: Insights into insulin action. Nat Rev Mol Cell Biol. 7:85–96. 2006. View Article : Google Scholar : PubMed/NCBI | |
Okada S, Crosson S, Mori M, Saltiel AR and Pessin JE: Insulin action, post-receptor mechanisms. Encyclopedia of Endocrine Diseases. Martini L: Elsevier; pp. 14–22. 2004, View Article : Google Scholar | |
Accili D and Arden KC: FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell. 117:421–426. 2004. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Mei H, Shan W, Shi L, Chang X, Zhu Y, Chen F and Han X: Lentinan protects pancreatic β cells from STZ-induced damage. J Cell Mol Med. 20:1803–1812. 2016. View Article : Google Scholar : PubMed/NCBI | |
Luo Y and Lei M: α-Mangostin protects against high-glucose induced apoptosis of human umbilical vein endothelial cells. Biosci Rep. 37:BSR201707792017. View Article : Google Scholar | |
Volpe CMO, Villar-Delfino PH, Dos Anjos PMF and Nogueira-Machado JA: Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis. 9:1192018. View Article : Google Scholar : PubMed/NCBI | |
Husen SA, Salamun, Ansori ANM, Joko R, Susilo K, Hayaza S and Winarni D: The effect of alpha-mangostin in glucose level, cholesterol level and diameter of the islets of langerhans of STZ-induced diabetic mice. In: Proceedings of the 2nd International Conference Postgraduate School (ICPS 2018); Science and Technology Publications, Lda; pp. 561–566. 2018 | |
Kurniawati M, Mahdi C and Aulanni'am A: The effect of juice mangosteen rind (Garcinia mangostana L.) to blood sugar levels and histological of pancreatic rats with the induction of streptozotocin. J Pure App Chem Res. 3:1–6. 2014. View Article : Google Scholar | |
Jariyapongskul A, Areebambud C, Suksamrarn S and Mekseepralard CJBri: Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats. Biomed Res Int. 2015:7858262015. View Article : Google Scholar : PubMed/NCBI | |
Paul S, Ali A and Katare R: Molecular complexities underlying the vascular complications of diabetes mellitus-a comprehensive review. J Diabetes Complications. 34:1076132020. View Article : Google Scholar | |
Djeujo FM, Francesconi V, Gonella M, Ragazzi E, Tonelli M and Froldi G: Anti-α-glucosidase and antiglycation activities of α-mangostin and new xanthenone derivatives: Enzymatic kinetics and mechanistic insights through in vitro studies. Molecules. 27:5472022. View Article : Google Scholar | |
Kumar V, Bhatt PC, Kaithwas G, Rashid M, Al-abbasi F, Khan J, Anwar F and Verma A: α-Mangostin mediated pharmacological modulation of hepatic carbohydrate metabolism in diabetes induced Wistar rat. Beni-Suef Univ J Basic Appl Sci. 5:255–276. 2016. | |
Watanabe M, Gangitano E, Francomano D, Addessi E, Toscano R, Costantini D, Tuccinardi D, Mariani S, Basciani S, Spera G, et al: Mangosteen extract shows a potent insulin sensitizing effect in obese female patients: A prospective randomized controlled pilot study. Nutrients. 10:5862018. View Article : Google Scholar : | |
Ratwita W, Sukandar EY, Adnyana IK and Kurniati NF: Alpha mangostin and xanthone from Mangosteen (Garcinia mangostana L.) role on glucose tolerance and glucose transporter-4 in diabetes mellitus. Int J Pharmacogn Phytochem Res. 9:1206–1212. 2017. | |
Rusman JRA, Sundari SA, Nuriliani A and Saragih HT: Ameliorative effect of Mangosteen (Garcinia mangostana L.) peel infusion on the histopathological structures of the liver and kidney of rats (Rattus norvegicus Berkenhout, 1769) after H2O2 induction. Vet World. 14:1579–1587. 2021. View Article : Google Scholar : PubMed/NCBI | |
Hassan AA, Moustafa EM, EL-Khashab IH and Mansour SZ: Mangosteen hinders gamma radiation-mediated oxidative stress and liver injury by down-regulating TNF-α/NF-κB and pro-fibrotic factor TGF-β1 inducing inflammatory signaling. Dose Response. 19:155932582110251902021. View Article : Google Scholar | |
Yan XT, Sun YS, Ren S, Zhao LC, Liu WC, Chen C, Wang Z and Li W: Dietary α-mangostin provides protective effects against acetaminophen-induced hepatotoxicity in mice via Akt/mTOR-mediated inhibition of autophagy and apoptosis. Int J Mol Sci. 19:13352018. View Article : Google Scholar | |
Fu T, Li H, Zhao Y, Cai E, Zhu H, Li P and Liu J: Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice. Biomed Pharmacother. 106:896–901. 2018. View Article : Google Scholar : PubMed/NCBI | |
Abood WN, Bradosty SW, Shaikh FK, Salehen N, Farghadani R, Agha FS, Al-Medhtiy MH, Kamil TDA, Agha S, Abdulla MA, et al: Garcinia mangostana peel extracts exhibit hepatoprotective activity against thioacetamide-induced liver cirrhosis in rats. J Funct Foods. 74:1042002020. View Article : Google Scholar | |
Dewidar B, Meyer C, Dooley S and Meindl-Beinker N: TGF-β in hepatic stellate cell activation and liver fibrogenesis-updated 2019. Cells. 8:14192019. View Article : Google Scholar | |
Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K and Wakasa K: In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol. 37:56–62. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yang L, Li P, Fu S, Calay ES and Hotamisligil GS: Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 11:467–478. 2010. View Article : Google Scholar : PubMed/NCBI | |
Inami Y, Yamashina S, Izumi K, Ueno T, Tanida I, Ikejima K and Watanabe S: Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression. Biochem Biophys Res Commun. 412:618–625. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, et al: Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest. 122:2428–2438. 2012. View Article : Google Scholar : PubMed/NCBI | |
Jiang M, Huang S, Duan W, Liu Q and Lei M: Alpha-mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway. J Cell Mol Med. 25:3601–3609. 2021. View Article : Google Scholar : PubMed/NCBI | |
Rahmaniah R, Yuyuntia Y, Soetikno V, Arozal W, Antarianto RD and Louisa M: Alpha mangostin inhibits hepatic stellate cells activation through TGF-β/smad and AKT signaling pathways: An in vitro study in LX2. Drug Res (Stuttg). 8:153–158. 2018. | |
Shibata MA, Harada-Shiba M, Shibata E, Tosa H, Matoba Y, Hamaoka H, Iinuma M and Kondo Y: Crude α-mangostin suppresses the development of atherosclerotic lesions in apoe-deficient mice by a possible M2 macrophage-mediated mechanism. Int J Mol Sci. 20:17222019. View Article : Google Scholar | |
Lestari N, Louisa M, Soetikno V, Suwana AG, Ramadhan PA, Akmal T and Arozal W: Alpha mangostin inhibits the proliferation and activation of acetaldehyde induced hepatic stellate cells through TGF-β and ERK 1/2 pathways. J Toxicol. 2018:53604962018. View Article : Google Scholar | |
Chae HS, Kim HJ, Ko HJ, Lee CH, Choi YH and Chin YW: Transcriptome analysis illuminates a hub role of SREBP2 in cholesterol metabolism by α-mangostin. ACS Omega. 5:31126–31136. 2020. View Article : Google Scholar : PubMed/NCBI | |
Boonprom P, Boonla O, Chayaburakul K, Welbat JU, Pannangpetch P, Kukongviriyapan U, Kukongviriyapan V, Pakdeechote P and Prachaney P: Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47phox and iNOS in nitric oxide deficient rats. Ann Anat. 212:27–36. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sampath PD and Kannan V: Mitigation of mitochondrial dysfunction and regulation of eNOS expression during experimental myocardial necrosis by alpha-mangostin, a xanthonic derivative from Garcinia mangostana. Drug Chem Toxicol. 32:344–352. 2009. View Article : Google Scholar : PubMed/NCBI | |
Jittiporn K, Moongkarndi P, Samer J and Suvitayavat W: Protective effect of α-mangostin on high glucose induced endothelial cell apoptosis. Walailak J Sci Technol. 15:579–587. 2018. View Article : Google Scholar | |
Tousian H, Razavi BM and Hosseinzadeh H: Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. Daru. 28:45–55. 2020. View Article : Google Scholar : | |
Fang Z, Luo W and Luo Y: Protective effect of α-mangostin against CoCl2-induced apoptosis by suppressing oxidative stress in H9C2 rat cardiomyoblasts. Mol Med Rep. 17:6697–6704. 2018.PubMed/NCBI | |
Chen LG, Yang LL and Wang CC: Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol. 46:688–693. 2008. View Article : Google Scholar | |
Förstermann U, Xia N and Li H: Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis. Circ Res. 120:713–735. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chaurasia B and Summers SA: Ceramides-lipotoxic inducers of metabolic disorders. Trends Endocrinol Metab. 26:538–550. 2015. View Article : Google Scholar : PubMed/NCBI | |
Okudaira C, Ikeda Y, Kondo S, Furuya S, Hirabayashi Y, Koyano T, Saito Y and Umezawa K: Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa. J Enzyme Inhib. 15:129–138. 2000. View Article : Google Scholar : PubMed/NCBI | |
Idris-Khodja N, Ouerd S, Mian MOR, Gornitsky J, Barhoumi T, Paradis P and Schiffrin EL: Endothelin-1 overexpression exaggerates diabetes-induced endothelial dysfunction by altering oxidative stress. Am J Hypertens. 29:1245–1251. 2016. View Article : Google Scholar : PubMed/NCBI | |
Schneider JG, Tilly N, Hierl T, Sommer U, Hamann A, Dugi K, Leidig-Bruckner G and Kasperk C: Elevated plasma endothelin-1 levels in diabetes mellitus. Am J Hypertens. 15:967–972. 2002. View Article : Google Scholar : PubMed/NCBI | |
Eisvand F, Imenshahidi M, Ghasemzadeh Rahbardar M, Tabatabaei Yazdi SA, Rameshrad M, Razavi BM and Hosseinzadeh H: Cardioprotective effects of alpha-mangostin on doxorubicin-induced cardiotoxicity in rats. Phytother Res. 36:506–524. 2022. View Article : Google Scholar | |
Wu Y, Pan N, An Y, Xu M, Tan L and Zhang L: Diagnostic and prognostic biomarkers for myocardial infarction. Front Cardiovasc Med. 7:6172772021. View Article : Google Scholar : PubMed/NCBI | |
Aydin S, Ugur K, Aydin S, Sahin İ and Yardim M: Biomarkers in acute myocardial infarction: Current perspectives. Vasc Health Risk Manag. 15:1–10. 2019. View Article : Google Scholar : PubMed/NCBI | |
Soetikno V, Murwantara A, Andini P, Charlie F, Lazarus G, Louisa M and Arozal W: Alpha-mangostin improves cardiac hypertrophy and fibrosis and associated biochemical parameters in high-fat/high-glucose diet and low-dose streptozotocin injection-induced type 2 diabetic rats. J Exp Pharmacol. 12:27–38. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ismail AMZ, Sargowo D, Tjahjono CT, Widito S, Rizal A and Rahimah AF: The role of Garcinia mangostana pericarp extract as antioxidant to inhibit atherosclerosis process in high risk framingham score patient; original article. Heart Sci J. 2:25–29. 2021. View Article : Google Scholar | |
Adiputro DL, Khotimah H, Widodo MA, Romdoni R and Sargowo D: Effects of ethanolic extracts of Garcinia mangostana fruit pericap on oxidant-antioxidant status and foam cells in atherosclerotic rats. Oxid Antioxid Med Sci. 2:61–64. 2013. View Article : Google Scholar | |
Wihastuti TA, Widodo MA, Heriansyah T and Sari NAK: Study of the inhibition effect of ethanolic extract of mangosteen pericarp on atherogenesis in hypercholesterolemic rat. Asian Pac J Trop Dis. 5:830–834. 2015. View Article : Google Scholar | |
Wihastuti TA, Aini FN, Tjahjono CT and Heriansyah T: Dietary ethanolic extract of mangosteen pericarp reduces VCAM-1, perivascular adipose tissue and aortic intimal medial thickness in hypercholesterolemic rat model. Open Access Maced J Med Sci. 7:3158–3163. 2019. View Article : Google Scholar | |
Mittal M, Siddiqui MR, Tran K, Reddy SP and Malik AB: Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 20:1126–1167. 2014. View Article : Google Scholar : | |
He F, Antonucci L and Karin M: NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 41:405–416. 2020. View Article : Google Scholar : PubMed/NCBI | |
Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P and Liu Q: Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Sci Rep. 6:210182016. View Article : Google Scholar : PubMed/NCBI | |
Taguchi K and Yamamoto M: The KEAP1-NRF2 system in cancer. Front Oncol. 7:852017. View Article : Google Scholar : PubMed/NCBI | |
Chang CC, Chen CW, Owaga E, Lee WT, Liu TN and Hsieh RH: Mangosteen concentrate drink supplementation promotes antioxidant status and lactate clearance in rats after exercise. Nutrients. 12:14472020. View Article : Google Scholar : | |
Lazarus G, Alexander S, Kusuma GO, Wijaya K and Soetikno V: Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents. J Appl Pharm Sci. 10:035–039. 2020. | |
Harliansyah H, Rahmah NA and Kuslestari K: α-Mangosteen as An Oxidative Inhibitor in Hepatocellular Carcinoma. Indones J Cancer Chemoprevention. 12:106–113. 2021. View Article : Google Scholar | |
Sanghvi VR, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, Miele MM, Lailler N, Zhao C, de Stanchina E, et al: The oncogenic action of NRF2 depends on de-glycation by fructosamine-3-kinase. Cell. 178:807–819.e21. 2019. View Article : Google Scholar : PubMed/NCBI | |
Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I and Pedraza-Chaverri J: The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel). 8:1332019. View Article : Google Scholar | |
Chuang CJ, Wang M, Yeh JH, Chen TC, Tsou SC, Lee YJ, Chang YY and Lin HW: The protective effects of α-mangostin attenuate sodium iodate-induced cytotoxicity and oxidative injury via mediating SIRT-3 inactivation via the PI3K/AKT/PGC-1α pathway. Antioxidants (Basel). 10:18702021. View Article : Google Scholar | |
Ruankham W, Suwanjang W, Phopin K, Songtawee N, Prachayasittikul V and Prachayasittikul S: Modulatory effects of alpha-mangostin mediated by SIRT1/3-FOXO3a pathway in oxidative stress-induced neuronal cells. Front Nutr. 8:7144632022. View Article : Google Scholar : PubMed/NCBI | |
Zhang J, Xiang H, Liu J, Chen Y, He RR and Liu B: Mitochondrial sirtuin 3: New emerging biological function and therapeutic target. Theranostics. 10:8315–8342. 2020. View Article : Google Scholar : PubMed/NCBI | |
Hotamisligil GS, Shargill NS and Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science. 259:87–91. 1993. View Article : Google Scholar : PubMed/NCBI | |
Halberg N, Wernstedt-Asterholm I and Scherer PE: The adipocyte as an endocrine cell. Endocrinol Metab Clin North Am. 37:753–768. 2008. View Article : Google Scholar : PubMed/NCBI | |
Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS and Obin MS: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 46:2347–2355. 2005. View Article : Google Scholar : PubMed/NCBI | |
Trayhurn P and Wood IS: Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 92:347–355. 2004. View Article : Google Scholar : PubMed/NCBI | |
Ellulu MS, Patimah I, Khaza'ai H, Rahmat A and Abed Y: Obesity and inflammation: The linking mechanism and the complications. Arch Med Sci. 13:851–863. 2017. View Article : Google Scholar : PubMed/NCBI | |
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218. 2017. View Article : Google Scholar | |
Yin P, Zou W, Li J, Jin N, Gao Q and Liu F: Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin. Sci Rep. 9:156262019. View Article : Google Scholar | |
Zou W, Yin P, Shi Y, Jin N, Gao Q, Li J and Liu F: A novel biological role of α-mangostin via TAK1-NF-κB pathway against inflammatory. Inflammation. 42:103–112. 2019. View Article : Google Scholar | |
Mohan S, Syam S, Abdelwahab SI and Thangavel N: An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach. Food Funct. 9:3860–3871. 2018. View Article : Google Scholar : PubMed/NCBI | |
Dong BM, Abano JB and Egan TM: Nitric oxide ventilation of rat lungs from non-heart-beating donors improves posttransplant function. Am J Transplant. 9:2707–2715. 2009. View Article : Google Scholar : PubMed/NCBI | |
Widowati W, Darsono L, Suherman J, Fauziah N, Maesaroh M and Erawijantari PP: Anti-inflammatory effect of mangosteen (Garcinia mangostana L.) peel extract and its compounds in LPS-induced RAW264.7 cells. Nat Prod Sci. 22:147–153. 2016. View Article : Google Scholar | |
Franceschelli S, Pesce M, Ferrone A, Patruno A, Pasqualone L, Carlucci G, Ferrone V, Carlucci M, de Lutiis MA, Grilli A, et al: A novel biological role of α-mangostin in modulating inflammatory response through the activation of SIRT-1 signaling pathway. J Cell Physiol. 231:2439–2451. 2016. View Article : Google Scholar : PubMed/NCBI | |
Sugiyanto Z, Yohan B, Hadisaputro S, Dharmana E, Suharti C, Winarto, Djamiatun K, Rahmi FL and Sasmono RT: Inhibitory effect of alpha-mangostin to dengue virus replication and cytokines expression in human peripheral blood mononuclear cells. Nat Prod Bioprospect. 9:345–349. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yin Q, Wu YJ, Pan S, Wang DD, Tao MQ, Pei WY and Zuo J: Activation of cholinergic anti-inflammatory pathway in peripheral immune cells involved in therapeutic actions of α-mangostin on collagen-induced arthritis in rats. Drug Des Devel Ther. 14:1983–1993. 2020. View Article : Google Scholar : | |
Tarasuk M, Songprakhon P, Chimma P, Sratongno P, Na-Bangchang K and Yenchitsomanus PT: Alpha-mangostin inhibits both dengue virus production and cytokine/chemokine expression. Virus Res. 240:180–189. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yongpitakwattana P, Morchang A, Panya A, Sawasdee N and Yenchitsomanus PT: Alpha-mangostin inhibits dengue virus production and pro-inflammatory cytokine/chemokine expression in dendritic cells. Arch Virol. 166:1623–1632. 2021. View Article : Google Scholar : PubMed/NCBI | |
Herrera-Aco DR, Medina-Campos ON, Pedraza-Chaverri J, Sciutto-Conde E, Rosas-Salgado G and Fragoso-González G: Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice. Food Chem Toxicol. 124:300–315. 2019. View Article : Google Scholar | |
Zuo J, Yin Q, Wang YW, Li Y, Lu LM, Xiao ZG, Wang GD and Luan JJ: Inhibition of NF-κB pathway in fibroblast-like synoviocytes by α-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis. Int Immunopharmacol. 56:78–89. 2018. View Article : Google Scholar : PubMed/NCBI | |
Pan T, Wu D, Cai N, Chen R, Shi X, Li B and Pan J: Alpha-mangostin protects rat articular chondrocytes against IL-1β-induced inflammation and slows the progression of osteoarthritis in a rat model. Int Immunopharmacol. 52:34–43. 2017. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Zhou H and Cai L: Alpha-mangostin attenuates oxidative stress and inflammation in adjuvant-induced arthritic rats. Trop J Pharm Res. 16:2611–2616. 2017. View Article : Google Scholar | |
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ and Ting JP: Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 12:408–415. 2011. View Article : Google Scholar : PubMed/NCBI | |
Duan Y, Zeng L, Zheng C, Song B, Li F, Kong X and Xu K: Inflammatory links between high fat diets and diseases. Front Immunol. 9:26492018. View Article : Google Scholar : PubMed/NCBI | |
Nava Catorce M, Acero G, Pedraza-Chaverri J, Fragoso G, Govezensky T and Gevorkian G: Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. J Neuroimmunol. 297:20–27. 2016. View Article : Google Scholar : PubMed/NCBI | |
Yang Z, Yin Q, Olatunji OJ, Li Y, Pan S, Wang DD and Zuo J: Activation of cholinergic anti-inflammatory pathway involved in therapeutic actions of α-mangostin on lipopolysaccharide-induced acute lung injury in rats. Int J Immunopathol Pharmacol. 34:20587384209549412020. View Article : Google Scholar | |
Tatiya-Aphiradee N, Chatuphonprasert W and Jarukamjorn K: Anti-inflammatory effect of Garcinia mangostana Linn. pericarp extract in methicillin-resistant Staphylococcus aureus-induced superficial skin infection in mice. Biomed Pharmacother. 111:705–713. 2019. View Article : Google Scholar : PubMed/NCBI | |
Lim YK, Yoo SY, Jang YY, Lee BC, Lee DS and Kook JK: Anti-inflammatory and in vitro bone formation effects of Garcinia mangostana L. and propolis extracts. Food Sci Biotechnol. 29:539–548. 2020. View Article : Google Scholar : PubMed/NCBI | |
Xie Z, Sintara M, Chang T and Ou B: Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: A randomized, double-blind, placebo-controlled clinical trial. Food Sci Nutr. 3:342–348. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chitchumroonchokchai C, Thomas-Ahner JM, Li J, Riedl KM, Nontakham J, Suksumrarn S, Clinton SK, Kinghorn AD and Failla ML: Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol Nutr Food Res. 57:203–211. 2013. View Article : Google Scholar | |
Nelli GB, K AS and Kilari EK: Antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats. Syst Biol Reprod Med. 59:319–328. 2013. View Article : Google Scholar : PubMed/NCBI | |
Choi YH, Han SY, Kim YJ, Kim YM and Chin YW: Absorption, tissue distribution, tissue metabolism and safety of α-mangostin in mangosteen extract using mouse models. Food Chem Toxicol. 66:140–146. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kittipaspallop W, Taepavarapruk P, Chanchao C and Pimtong W: Acute toxicity and teratogenicity of α-mangostin in zebrafish embryos. Exp Biol Med (Maywood). 243:1212–1219. 2018. View Article : Google Scholar | |
Fajeriyati N, Muchtaridi M and Sopyan I: Methods For improving alpha-mangostin solubility: A review. Int J Appl Pharm. 13:47–54. 2021. View Article : Google Scholar | |
Aisha AF, Ismail Z, Abu-Salah KM and Majid AM: Solid dispersions of α-mangostin improve its aqueous solubility through self-assembly of nanomicelles. J Pharm Sci. 101:815–825. 2012. View Article : Google Scholar | |
Savjani KT, Gajjar AK and Savjani JK: Drug solubility: Importance and enhancement techniques. ISRN Pharm. 2012:1957272012.PubMed/NCBI | |
Wathoni N, Rusdin A, Motoyama K, Joni IM, Lesmana R and Muchtaridi M: Nanoparticle drug delivery systems for α-mangostin. Nanotechnol Sci Appl. 13:23–36. 2020. View Article : Google Scholar : | |
Li L, Han AR, Kinghorn AD, Frye RF, Derendorf H and Butterweck V: Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats. Plant Med. 79:646–653. 2013. View Article : Google Scholar | |
Foti RS, Pearson JT, Rock DA, Wahlstrom JL and Wienkers LC: In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract. Drug Metab Dispos. 37:1848–1855. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kondo M, Zhang L, Ji H, Kou Y and Ou B: Bioavailability and antioxidant effects of a xanthone-rich mangosteen (Garcinia mangostana) product in humans. J Agric Food Chem. 57:8788–8792. 2009. View Article : Google Scholar : PubMed/NCBI | |
Singhal S, Hasan N, Nirmal K, Chawla R, Chawla S, Kalra BS and Dhal A: Bioavailable turmeric extract for knee osteoarthritis: A randomized, non-inferiority trial versus paracetamol. Trials. 22:1052021. View Article : Google Scholar : PubMed/NCBI | |
Bumrungpert A, Kalpravidh RW, Suksamrarn S, Chaivisuthangkura A, Chitchumroonchokchai C and Failla ML: Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (mangosteen) using simulated digestion and Caco-2 human intestinal cells. Mol Nutr Food Res. 53(Suppl 1): S54–S61. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chitchumroonchokchai C, Riedl KM, Suksumrarn S, Clinton SK, Kinghorn AD and Failla ML: Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. J Nutr. 142:675–680. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rukthong P, Sereesongsang N, Kulsirirat T, Boonnak N and Sathirakul K: In vitro investigation of metabolic fate of α-mangostin and gartanin via skin permeation by LC-MS/MS and in silico evaluation of the metabolites by ADMET predictor™. BMC Complement Med Ther. 20:3592020. View Article : Google Scholar | |
Thassu D, Pathak Y and Deleers M: Nanoparticulate drug-delivery systems: An overview Nanoparticulate drug delivery systems. CRC Press; Boca Raton, FL: pp. 1–31. 2007 | |
Usman F, Shah HS, Zaib S, Manee S, Mudassir J, Khan A, Batiha GE, Abualnaja KM, Alhashmialameer D and Khan I: Fabrication and biological assessment of antidiabetic α-mangostin loaded nanosponges: In vitro, in vivo, and in silico studies. Molecules. 26:66332021. View Article : Google Scholar | |
Sodalee K, Sapsuphan P, Wongsirikul R and Puttipipatkhachorn S: Preparation and evaluation of alpha-mangostin solid self-emulsifying drug delivery system. Asian J Pharm Sci. 11:225–226. 2016. View Article : Google Scholar | |
Xu WK, Jiang H, Yang K, Wang YQ, Zhang Q and Zuo J: Development and in vivo evaluation of self-microemulsion as delivery system for α-mangostin. Kaohsiung J Med Sci. 33:116–123. 2017. View Article : Google Scholar : PubMed/NCBI | |
Mahmudah R, Adnyana IK and Sukandar EY: Molecular docking studies of α-mangostin, γ-mangostin, and xanthone on peroxisome proliferator-activated receptor gamma diphenyl peptidase-4 enzyme, and aldose reductase enzyme as an antidiabetic drug candidate. J Adv Pharm Technol Res. 12:196–208. 2021. View Article : Google Scholar : PubMed/NCBI | |
Sunitha J, Mahendra J, Mahendra L and Devaraj N: Molecular docking studies of a-mangostin with oral cancer targets ARRB1, FLNA, CALM3 and HTT. Bioinformation. 16:625–630. 2020. View Article : Google Scholar : PubMed/NCBI | |
Herz CT and Kiefer FW: Adipose tissue browning in mice and humans. J Endocrinol. 241:R97–R109. 2019. View Article : Google Scholar : PubMed/NCBI | |
Choi H, Kim CS and Yu R: Quercetin upregulates uncoupling protein 1 in white/brown adipose tissues through sympathetic stimulation. J Obes Metab Syndr. 27:102–109. 2018. View Article : Google Scholar | |
Wang S, Liang X, Yang Q, Fu X, Zhu M, Rodgers BD, Jiang Q, Dodson MV and Du M: Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) α1 in mice fed high-fat diet. Mol Nutr Food Res. 61: View Article : Google Scholar : 2017. |