Open Access

Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review)

  • Authors:
    • Zufang Liao
    • Rongjiong Zheng
    • Guofeng Shao
  • View Affiliations

  • Published online on: December 5, 2022     https://doi.org/10.3892/ijmm.2022.5210
  • Article Number: 7
  • Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the progression of various diseases, inflammation has a critical role. Chronic persistent inflammation is a pivotal trigger of fibrosis. Several microRNAs (miRNAs) participate in inflammation and fibrosis. In recent years, it has been proved that miRNAs are a critical link in physiological and pathological processes. Among them, the miRNA miR‑146a has a pivotal role in the immune system and acquired immunity, making it one of the most studied miRNAs. Due to its essential roles at the molecular and cellular levels, it has broad application prospects in precision medicine. The present comprehensive review focused on the mechanisms of miR‑146a and its application strategies in inflammation and fibrosis, discussing its therapeutic potential. The main signaling pathways through which miR‑146a regulates inflammation and fibrosis and their relationships were covered. Furthermore, the functions and effects of miR‑146a in specific cells, which may join in the process of inflammation and fibrosis, were outlined. Application strategies were also summarized according to recent studies based on these mechanisms.
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January-2023
Volume 51 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Liao Z, Zheng R and Shao G: Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review). Int J Mol Med 51: 7, 2023.
APA
Liao, Z., Zheng, R., & Shao, G. (2023). Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review). International Journal of Molecular Medicine, 51, 7. https://doi.org/10.3892/ijmm.2022.5210
MLA
Liao, Z., Zheng, R., Shao, G."Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review)". International Journal of Molecular Medicine 51.1 (2023): 7.
Chicago
Liao, Z., Zheng, R., Shao, G."Mechanisms and application strategies of miRNA‑146a regulating inflammation and fibrosis at molecular and cellular levels (Review)". International Journal of Molecular Medicine 51, no. 1 (2023): 7. https://doi.org/10.3892/ijmm.2022.5210