Obesity alters inflammatory response in the pathology of asthma (Review)

  • Authors:
    • Ziwen Qin
    • Hong Yang
    • Junli Liu
    • Dongxiao Li
    • Yue Wang
    • Yujuan Chen
    • Chuanjun Huang
  • View Affiliations

  • Published online on: June 6, 2023     https://doi.org/10.3892/ijmm.2023.5266
  • Article Number: 63
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Abstract

Obesity is one of the comorbidities in patients with asthma and obese patients with asthma present with a distinct phenotype with more severe disease outcomes and reduced responsiveness to standard therapies. Although the full mechanisms of obesity‑related asthma are still not completely understood, abnormal immune responses have been demonstrated to have a critical role in asthma pathogenesis. The present review summarizes the data from clinical, epidemiological and animal studies to provide an updated understanding of the immune responses in obesity‑related asthma, as well as the effect of various factors, such as oxidative stress, mitochondrial dysfunction, genetics and epigenetics, on asthmatic inflammation. Further studies on the in‑depth mechanisms are still required to develop novel preventive and therapeutic strategies for patients with asthma combined with obesity.
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July-2023
Volume 52 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Qin Z, Yang H, Liu J, Li D, Wang Y, Chen Y and Huang C: Obesity alters inflammatory response in the pathology of asthma (Review). Int J Mol Med 52: 63, 2023.
APA
Qin, Z., Yang, H., Liu, J., Li, D., Wang, Y., Chen, Y., & Huang, C. (2023). Obesity alters inflammatory response in the pathology of asthma (Review). International Journal of Molecular Medicine, 52, 63. https://doi.org/10.3892/ijmm.2023.5266
MLA
Qin, Z., Yang, H., Liu, J., Li, D., Wang, Y., Chen, Y., Huang, C."Obesity alters inflammatory response in the pathology of asthma (Review)". International Journal of Molecular Medicine 52.1 (2023): 63.
Chicago
Qin, Z., Yang, H., Liu, J., Li, D., Wang, Y., Chen, Y., Huang, C."Obesity alters inflammatory response in the pathology of asthma (Review)". International Journal of Molecular Medicine 52, no. 1 (2023): 63. https://doi.org/10.3892/ijmm.2023.5266