Open Access

Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review)

  • Authors:
    • Alexandros Velegrakis
    • Elisavet Kouvidi
    • Persefoni Fragkiadaki
    • Stavros Sifakis
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  • Published online on: August 9, 2023     https://doi.org/10.3892/ijmm.2023.5292
  • Article Number: 89
  • Copyright: © Velegrakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preeclampsia (PE) is a major complication of pregnancy with an incidence rate of 2‑8% and is a leading cause of maternal mortality and morbidity. The various consequences of severe preeclampsia for the fetus, neonate and child include intrauterine growth retardation (IUGR), fetal hypoxia, oligohydramnios, intrauterine fetal demise, increased perinatal mortality and morbidity, neurodevelopmental disorders and even irreversible brain damage (cerebral palsy). A number of studies have demonstrated that differences in maternal serum concentrations of angiogenic factors between preeclampsia and normotensive pregnancies can be used as biomarkers, either alone or in combination with other markers, to predict the development of PE. The presence in the maternal circulation of two proteins of placental origin, placental growth factor (PlGF) and soluble fms‑like tyrosine kinase 1 (sFlt‑1), has been shown to be of clinical value, as the sFlt‑1/PlGF ratio appears to be the optimal predictive tool for the development of PE. The measurement of their concentration in maternal serum in screening models, serves as predictive marker for the development of PE or IUGR later in gestation. However, further research is required to improve its clinical applicability and provide guidelines for its use worldwide to achieve more consistent clinical management of women with PE.
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October-2023
Volume 52 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Velegrakis A, Kouvidi E, Fragkiadaki P and Sifakis S: Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review). Int J Mol Med 52: 89, 2023.
APA
Velegrakis, A., Kouvidi, E., Fragkiadaki, P., & Sifakis, S. (2023). Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review). International Journal of Molecular Medicine, 52, 89. https://doi.org/10.3892/ijmm.2023.5292
MLA
Velegrakis, A., Kouvidi, E., Fragkiadaki, P., Sifakis, S."Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review)". International Journal of Molecular Medicine 52.4 (2023): 89.
Chicago
Velegrakis, A., Kouvidi, E., Fragkiadaki, P., Sifakis, S."Predictive value of the sFlt‑1/PlGF ratio in women with suspected preeclampsia: An update (Review)". International Journal of Molecular Medicine 52, no. 4 (2023): 89. https://doi.org/10.3892/ijmm.2023.5292