Open Access

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

  • Authors:
    • Wanlu Ye
    • Nan Xiang
    • Qing Wang
    • Yanming Lu
  • View Affiliations

  • Published online on: March 5, 2024     https://doi.org/10.3892/ijmm.2024.5365
  • Article Number: 41
  • Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNA (circRNA), a type of non‑coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, migration, invasion and apoptosis of tumor cells through the ceRNA mechanism. With further research, circRNAs may serve as novel markers and therapeutic targets for ovarian cancer (OC). In the present review, the research progress of circRNAs as ceRNAs in OC was summarized, focusing on the effects of the circRNA/miRNA/mRNA axis on the biological functions of OC cells through mediating pivotal signaling pathways. The role of circRNAs in the diagnosis, prognostic assessment and treatment of OC was also discussed in the present review.
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May-2024
Volume 53 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Ye W, Xiang N, Wang Q and Lu Y: Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). Int J Mol Med 53: 41, 2024.
APA
Ye, W., Xiang, N., Wang, Q., & Lu, Y. (2024). Role of circular RNA as competing endogenous RNA in ovarian cancer (Review). International Journal of Molecular Medicine, 53, 41. https://doi.org/10.3892/ijmm.2024.5365
MLA
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53.5 (2024): 41.
Chicago
Ye, W., Xiang, N., Wang, Q., Lu, Y."Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)". International Journal of Molecular Medicine 53, no. 5 (2024): 41. https://doi.org/10.3892/ijmm.2024.5365