Open Access

Promising predictive molecular biomarkers for cervical cancer (Review)

  • Authors:
    • Marcela Lizano
    • Adela Carrillo‑García
    • Erick De La Cruz‑Hernández
    • Leonardo Josué Castro‑Muñoz
    • Adriana Contreras‑Paredes
  • View Affiliations

  • Published online on: April 4, 2024     https://doi.org/10.3892/ijmm.2024.5374
  • Article Number: 50
  • Copyright: © Lizano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer (CC) constitutes a serious public health problem. Vaccination and screening programs have notably reduced the incidence of CC worldwide by >80%; however, the mortality rate in low‑income countries remains high. The staging of CC is a determining factor in therapeutic strategies: The clinical management of early stages of CC includes surgery and/or radiotherapy, whereas radiotherapy and/or concurrent chemotherapy are the recommended therapeutic strategies for locally advanced CC. The histopathological characteristics of tumors can effectively serve as prognostic markers of radiotherapy response; however, the efficacy rate of radiotherapy may significantly differ among cancer patients. Failure of radiotherapy is commonly associated with a higher risk of recurrence, persistence and metastasis; therefore, radioresistance remains the most important and unresolved clinical problem. This condition highlights the importance of precision medicine in searching for possible predictive biomarkers to timely identify patients at risk of treatment response failure and provide tailored therapeutic strategies according to genetic and epigenetic characteristics. The present review aimed to summarize the evidence that supports the role of several proteins, methylation markers and non‑coding RNAs as potential predictive biomarkers for CC.
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June-2024
Volume 53 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lizano M, Carrillo‑García A, De La Cruz‑Hernández E, Castro‑Muñoz LJ and Contreras‑Paredes A: Promising predictive molecular biomarkers for cervical cancer (Review). Int J Mol Med 53: 50, 2024.
APA
Lizano, M., Carrillo‑García, A., De La Cruz‑Hernández, E., Castro‑Muñoz, L.J., & Contreras‑Paredes, A. (2024). Promising predictive molecular biomarkers for cervical cancer (Review). International Journal of Molecular Medicine, 53, 50. https://doi.org/10.3892/ijmm.2024.5374
MLA
Lizano, M., Carrillo‑García, A., De La Cruz‑Hernández, E., Castro‑Muñoz, L. J., Contreras‑Paredes, A."Promising predictive molecular biomarkers for cervical cancer (Review)". International Journal of Molecular Medicine 53.6 (2024): 50.
Chicago
Lizano, M., Carrillo‑García, A., De La Cruz‑Hernández, E., Castro‑Muñoz, L. J., Contreras‑Paredes, A."Promising predictive molecular biomarkers for cervical cancer (Review)". International Journal of Molecular Medicine 53, no. 6 (2024): 50. https://doi.org/10.3892/ijmm.2024.5374