Open Access

Public neoantigens in breast cancer immunotherapy (Review)

  • Authors:
    • Natthaporn Sueangoen
    • Peti Thuwajit
    • Pa-Thai Yenchitsomanus
    • Chanitra Thuwajit
  • View Affiliations

  • Published online on: June 17, 2024     https://doi.org/10.3892/ijmm.2024.5388
  • Article Number: 65
  • Copyright: © Sueangoen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Among women globally, breast cancer is the most prevalent cancer and the leading cause of cancer‑related death. Interestingly, though genetic mutations contribute to the disease, <15% of women diagnosed with breast cancer have a family history of the disease, suggesting a prevalence of sporadic genetic mutations in breast cancer development. In the rapidly rising field of cancer genomics, neoantigen‑based immunotherapy has come to the fore. The investigation of novel proteins arising from unique somatic mutations or neoantigens have opened a new pathway for both individualized and public cancer treatments. Because they are shared among individuals with similar genetic changes, public neoantigens provide an opportunity for ‘off‑the‑shelf’ anticancer therapies, potentially extending the benefits to a wider patient group. The present review aimed to highlight the role of shared or public neoantigens as therapeutic targets for patients with breast cancer, emphasizing common hotspot mutations of certain genes identified in breast cancer. The clinical utilization of public neoantigen‑based therapies for breast cancer treatment were also discussed.
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July-2024
Volume 54 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Sueangoen N, Thuwajit P, Yenchitsomanus P and Thuwajit C: Public neoantigens in breast cancer immunotherapy (Review). Int J Mol Med 54: 65, 2024
APA
Sueangoen, N., Thuwajit, P., Yenchitsomanus, P., & Thuwajit, C. (2024). Public neoantigens in breast cancer immunotherapy (Review). International Journal of Molecular Medicine, 54, 65. https://doi.org/10.3892/ijmm.2024.5388
MLA
Sueangoen, N., Thuwajit, P., Yenchitsomanus, P., Thuwajit, C."Public neoantigens in breast cancer immunotherapy (Review)". International Journal of Molecular Medicine 54.1 (2024): 65.
Chicago
Sueangoen, N., Thuwajit, P., Yenchitsomanus, P., Thuwajit, C."Public neoantigens in breast cancer immunotherapy (Review)". International Journal of Molecular Medicine 54, no. 1 (2024): 65. https://doi.org/10.3892/ijmm.2024.5388