Open Access

Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review)

  • Authors:
    • Peng Qu
    • Lanfang Li
    • Qi Jin
    • Donghai Liu
    • Yuan Qiao
    • Yijia Zhang
    • Qiuyue Sun
    • Shuman Ran
    • Zecheng Li
    • Tongtong Liu
    • Liang Peng
  • View Affiliations

  • Published online on: September 17, 2024     https://doi.org/10.3892/ijmm.2024.5428
  • Article Number: 104
  • Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end‑stage renal disease, and is characterized by persistent proteinuria and decreased glomerular filtration rate. Despite extensive efforts, the increasing incidence highlights the urgent need for more effective treatments. Histone methylation is a crucial epigenetic modification, and its alteration can destabilize chromatin structure, thereby regulating the transcriptional activity of specific genes. Histone methylation serves a substantial role in the onset and progression of various diseases. In patients with DKD, changes in histone methylation are pivotal in mediating the interactions between genetic and environmental factors. Targeting these modifications shows promise in ameliorating renal histological manifestations, tissue fibrosis and proteinuria, and represents a novel therapeutic frontier with the potential to halt DKD progression. The present review focuses on the alterations in histone methylation during the development of DKD, systematically summarizes its impact on various renal parenchymal cells and underscores the potential of targeted histone methylation modifications in improving DKD outcomes.
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November-2024
Volume 54 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Qu P, Li L, Jin Q, Liu D, Qiao Y, Zhang Y, Sun Q, Ran S, Li Z, Liu T, Liu T, et al: Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review). Int J Mol Med 54: 104, 2024.
APA
Qu, P., Li, L., Jin, Q., Liu, D., Qiao, Y., Zhang, Y. ... Peng, L. (2024). Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review). International Journal of Molecular Medicine, 54, 104. https://doi.org/10.3892/ijmm.2024.5428
MLA
Qu, P., Li, L., Jin, Q., Liu, D., Qiao, Y., Zhang, Y., Sun, Q., Ran, S., Li, Z., Liu, T., Peng, L."Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review)". International Journal of Molecular Medicine 54.5 (2024): 104.
Chicago
Qu, P., Li, L., Jin, Q., Liu, D., Qiao, Y., Zhang, Y., Sun, Q., Ran, S., Li, Z., Liu, T., Peng, L."Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches (Review)". International Journal of Molecular Medicine 54, no. 5 (2024): 104. https://doi.org/10.3892/ijmm.2024.5428